Mentor / Lab:
Dr. Robert Geahlen
Specific Research Area / Project:
Syk of Microtubules: the story of a tyrosine kinase and the microtubule architecture of cancer cells
Rose-Hulman Institute of Technology
My research project encompasses studying the role of Syk, a tyrosine kinase, in breast cancer. The long-term goal of my thesis project is to decipher the mechanism by which Syk stabilizes microtubule architecture in cells. My research has shown that Syk enhances microtubule stability and plays a significant role in microtubule dynamics. I hypothesize that Syk plays a role in breast cancer motility via microtubule stability and modulation of signaling pathways involving motility via phosphorylation. My research is important because understanding how cancer cells become highly motile and metastasize is a major concern in terms of cancer drug design, treatment, and prevention.
My experience with Purdue and in the PULSe program is difficult to sum up in words, except for one phrase that comes to mind: an interdisciplinary family! Graduate school can be hectic at times with laboratory research, classes, etc., PULSe makes it very easy for students to transition into a graduate research atmosphere by providing valuable guidance, research laboratory experiences throughout the campus, travel funding for attending conferences, and fun picnics and socials with fellow grad students. One of my favorite memories/experiences in PULSe has been being involved in our Science in Schools outreach program. Each year we partner with a local elementary school to teach students how cool science can be! My favorite memory so far has been making elephant toothpaste with the students and hearing their reactions when the foam starts to shoot up... "I never knew science could be fun!"... yes it can be ;)
- National Science Foundation (NSF) Graduate Fellowship (2012-2015)
- Purdue Engagement Grant (2011-2012 and 2012-2013)
- Purdue Interdisciplinary Life Sciences (PULSe) Travel grant (Spring 2012)
- Purdue University Interdisciplinary Excellence Award (Spring 2013)
- Purdue University Interdisciplinary Life Science Program (PULSe) and the Women in Science Programs Travel Award (Spring 2013)
- M. Krisenko, W.H. Wang, and R. L. Geahlen. The role of Syk at the centrosome. Poster presented at the Office of Interdisciplinary Graduate Programs’ Spring Reception, West Lafayette, IN. April 2012.
- M. Krisenko, W.H. Wang, and R. L. Geahlen (2012, April) The role of Syk at the centrosome. Poster presented at the Tyrosine Kinase Signaling in Cancer, Disease, & Development Snowmass, Colorado. July 2012.
- M. Krisenko, W.H. Wang, and R. L. Geahlen (2012, April) The role of Syk at the centrosome. Poster presented at Next Generation Scholars Research Fair West Lafayette, IN. November 2012.
- M. Krisenko1*, Alexander Cartagena2, Wen-Horng Wang1, Liang Xue3, Anton Iliuk3, Andy Tao3, Arvind Raman2, and Robert L. Geahlen.1 1Department of Medicinal Chemistry and Molecular Pharmacology, 2School of Mechanical Engineering, 3Department of Biochemistry, Purdue University. Poster presented at the Office of Interdisciplinary Graduate Programs’ Spring Reception, West Lafayette, IN. April 2013.
- PULSe Science in Schools Volunteer (2010-Present)
- PULSe Science in Schools co-Chair (2011-Present)
- PULSe Graduate Student Government Treasurer (2011-2012)
- PULSe Graduate Student Government Vice-President (2012-2013)
- Clay Community School Corporation Science Fair Judge (2010-Present)
- Hoosier State Science and Engineering Grand Awards Judge (April 2013)