Jeff Grabowski

 Profile Picture
IGP:
PULSe

Mentor / Lab:
Catherine A. Hill and Richard J. Kuhn

Specific Research Area / Project:
Medical Entomology, Vector Biology, Molecular Virology / Tick-flavivirus interactions

Undergraduate Institution:
Manchester University, North Manchester, IN



Research Profile:

Vector-borne disease is of worldwide medical and veterinary importance. Arthropods of disease, such as mosquitoes and ticks, are responsible for the majority of arbo-borne pathogen transmission and are used as models to study pathogen infection. The natural transmission cycles of vector-borne pathogens that cause incidental human disease often involve an ecological interaction between a pathogen-amplifying reservoir animal and a pathogen-transmitting arthropod of disease. The long term goal of this collaborative research project is to identify possible ways to prevent the transmission of tick-borne flaviviruses (TBFs), which can cause hemorrhagic fever and encephalitis, leading to high human morbidity and mortality.

We have utilized and optimized an in vitro tick cell-TBF model system for the study of tick-flavivirus interactions. From this system, we have identified changing host eukaryotic proteins following TBF infection (manuscript in preparation). The identification of the required proteins for viral infection provides potential targets for further therapeutic development. The support of this project encompasses the College of Agriculture, College of Science, Bindley Bioscience Center Proteomics Facility, and Center for Global Research and Intervention in Infectious Diseases (C-GRIID). Contributors outside of Purdue University include researchers from University of Minnesota and NIH.


About Me:

 About Me Picture

After my sophomore year at Manchester University, I completed a summer REU program with Cary Institute for Ecosystem Studies working with experts on ecological Lyme disease dynamics. Since then, I have been addicted to vector-borne disease and, more specifically, to investigating how all the intricate parts of a disease transmission cycle come together. Currently, my graduate research focus has shifted to a more biomedical approach, in which the disciplines of genomics and molecular virology are intertwined. Since my acceptance into the interdisciplinary life science Ph.D program (PULSe) here at Purdue, the interdisciplinary aspects of the program have allowed for the development of a powerful collaborative project. The positive experience I gained from working with experts in the fields of arthropod genomics and molecular virology have provided me with the correct tools to provide high impact research and complete high impact outreach opportunities.


Awards:

  • Purdue Interdisciplinary Graduate Program Most Outstanding Project Award, 2012.
  • Purdue College of Agriculture TEAM Award (Purdue zipTrips Team), 2012.
  • Entomological Society of America NCB 3rd place Ph.D poster presentation, 2011.
  • PULSe 1st Year Poster Competition-Runners Up, 2010.

Publications:

  • Grabowski, J, Killilea, M, and Ostfeld, R. 2007. Invasive earthworm species effect on the density and microscale habitat of Ixodes scapularis nymphs in Dutchess County, NY. Undergraduate Ecology Research Reports 2007, Cary Institute (online publication: http://www.ecostudies.org/reprints/Grabowski_2007_REU.pdf).
  • Grabowski, J, Perera, R, Hill, C, and Kuhn, R. 2012. 31st Annual Meeting of American Society of Virology. University of Wisconsin-Madison. (submitted)
  • Grabowski, J, Perera, R, Hill, C, and Kuhn, R. 2012. 127th Annual Meeting of Indiana Academy of Science: Microbiology & Molecular Biology Section. Purdue University.
  • Perera, R, Riley, C, Junjohn, J, Edwards, T, Hopf-Jannasch, A, Mezengie, G, Grabowski, J, Hill, C, Metz, T, Moore, R, Weitz, K, Pasa-Tolic, L, Adamec, J, and Kuhn, R. 2011. Dengue virus alters membrane architecture and lipid composition of mammalian and insect cells during its replication cycle. 4th Annual Membrane Symposium on Center for Basic and Applied Studies on Membrane Proteins (PUBAMS). Purdue University. (Perera oral presention)
  • Grabowski, J, Killilea, M, and Ostfeld, R. 2007. Invasive earthworm species effect on the density and microscale habitat of Ixodes scapularis nymphs in Dutchess County, NY. 123rd Annual Meeting of Indiana Academy of Science: Ecology Section. University of Indianapolis.
  • Grabowski, J, Perera, R, Hill, C, and Kuhn, R. 2012. Interdisciplinary Graduate Program Reception. Purdue University.
  • Grabowski, J, Perera, R, Hill, C, and Kuhn, R. 2012. Purdue Chapter Sigma Xi Poster Award Competition. Purdue University.
  • Grabowski, J, Perera, R, Hill, C, and Kuhn, R. 2011. Biological Sciences Retreat. Purdue University.
  • Grabowski, J, Perera, R, Hill, C, and Kuhn, R. 2011. Interdisciplinary Graduate Program Reception. Purdue University.
  • Grabowski, J, Perera, R, Hill, C, and Kuhn, R. 2011. Entomological Society of America: North Central Branch Meeting. University of Minnesota.
  • Grabowski, J, Perera, R, Hill, C, and Kuhn, R. 2010. Purdue Chapter Sigma Xi Poster Award Competition. Purdue University.

Presentations:

  • Oral Presentation Title: Tick-flavivirus analysis and host proteomic change following infection - Annual ASV Meeting: Flavivirus I Section, Madison, WI. (submitted). 2012, Entm Soc America NCB Meeting, University of Nebraska, NE. (submitted). 2012, Annual IAS Meeting: Microbio & Mol Bio Section, Purdue University, IN. 2012, Methods Seminar, Department of Entomology, Purdue University, IN. 2012.
  • Poster Presentation Title: Langat virus growth in ISE6 cells and host proteomic change - Interdisciplinary Graduate Program Reception, Purdue University, IN. 2012, Purdue Chapter Sigma Xi Poster Award Competition, Purdue University, IN. 2012, Biological Sciences Retreat, Swan Lake Resort, Plymouth, IN. 2011.
  • Poster Presentation Title: Langat virus growth in ISE6 cells - Interdisciplinary Graduate Program Reception, Purdue University, IN. 2011, Entm Soc America NCB Meeting, University of Minnesota, MN. 2011, Purdue Chapter Sigma Xi Poster Award Competition, Purdue University, IN. 2010.
  • Oral Presentation Title: Lyme Disease Dynamics of Southern Kosciusko county, IN - Manchester College Science Seminar, N. Manchester, IN. 2008, Manchester College Student Research Symposium, N. Manchester, IN. 2009.
  • Oral Presentation Title: Invasive Earthworms and Nymphal Tick Interaction Dynamics - Annual Ind Acad Sci (IAS) Conference: Ecology Section, Indianapolis, IN. 2007, Cary Institute of Eco Stud REU Undergraduate Symposium, Millbrook, NY. 2007, Manchester College Science Seminar, N. Manchester, IN. 2007.

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