Dr. Irudayaraj's focus is to develop biosensors, nanotools, and single molecule methods relevant to detection, diagnosis, and prognosis of diseases. Single molecule methods as tools for understanding, asking, and answering fundamental biological questions are at the heart of our research and teaching efforts. Biosensing strategies with multiplexing capabilities to monitor single molecule events both at the cellular and molecular level are researched. Single particle optical methods and nanofabrication for multiplex probing of single cell surfaces and cellular matrices are our interest.
The basis for Dr. Irudayaraj's work stems from a strong background and skills developed in the areas of biospectroscopy, biosensors, and numerical modeling. Dr. Irudayaraj is also a Co-Director of the Physiological Sensing Facility (PSF) and a member of the Biophysics Core at Bindley and has authored over 125 refereed publications. Prior to Purdue, Dr. Irudayaraj was an Associate Professor at The Pennsylvania State University (1998-2004) and a visiting faculty (2004-2005) at the School of Applied and Engineering Physics at Cornell University (Dr. Harold Craighead's group).
Major instrumentation in our laboratory include Confocal Raman Microscopy (Two raman scopes with 4 laser lines), an integrated dual-color Fluorescence Correlation Spectroscopy, FRET, and 3D Fluorescence Lifetime Imaging (FLIM), (a multiphoton option coming soon!), TIRF (with 4 laser lines), Dark-field microscope/spectroscopy, A multiplex scanning SPR-based workstation; Confocal and fluorescence imaging, Surface Plasmon Resonance (SPR) Imager and sensors, Quartz Crystal microbalance and Amperometric sensors.
We work very closely with the Cytometry and Nanomedicine group in Bindley Biosciences Center; Bionanotechnology group at the Birck Nanotechnology Center, Molecular Motors group at the College of Veterinary Medicine, Cancer Research Center at the Indiana Medical College.
Students, visiting scholars, and faculty with research and collaborative interests are encouraged to contact Dr. Irudayaraj at josephi@purdue.edu [765-494-0388]
|
