Dr. Joseph Irudayaraj

Biographical Sketch

JOSEPH MK IRUDAYARAJ CURRICULUM VITAE

josephi@purdue.edu
225 S. University Street Cell: (765) 404-0499
West Lafayette ∙ Indiana 47907 Office: (765) 494-0388

QUICK PROFILE

Proactive and highly successful in spurring interdisciplinary collaboration with the departments of basic medical sciences, anatomy, biochemistry, chemistry, veterinary sciences, and medicinal chemistry and pharmacology. Research address areas in epigenetics and phosphorylation to detect and prevent cancer, protein structure elucidation to detect neurodegenerative diseases, and detection of threat agents through technology development comprising of single molecule techniques, hyperspectral Plasmon spectroscopy, and Raman chemical imaging. Developed and taught over twelve courses in basic and applied engineering and science. Published over 175 refereed journal articles. Active in industry sponsored grants and technology commercialization.

Professional and Service: Graduate Chair of Agricultural and Biological Engineering, member of advisory committee to the Dean of the College of Engineering, member of task force and strategic committee to interdisciplinary centers (Bindley Bioscience Center, Birck Nanotechnology Center, and Purdue Center for Cancer Research). Active in NIH, NSF, DOD, DOE, and Susan Komen Foundation review panels.

Other: Research and team grant writing expertise; course customization and training in education; business acumen; organization and leadership skills at the College and University level; program and core area (Cellular and Biomolecular Engineering) development (Undergraduate and Graduate).

Domestic and international orientation: Ongoing collaborations with UK, China, India, Brazil, and Italy. Fully bicultural and trilingual. Basic conversational Spanish.

EDUCATION

PhD Bioprocess Engineering, Purdue University, 1990
M.S. Biosystems Engineering, University of Hawaii, 1987
M.S. Computer Sciences, University of Hawaii, 1986
B.S. Agricultural Engineering, College of Agricultural Engineering, TNAU, India, 1983

PROFESSIONAL APPOINTMENTS / DISTINCTIONS

PROFESSOR, Biological Engineering and Graduate Chair 2009 - Present
Agricultural and Biological Engineering (ABE), University Faculty Scholar, Academic Leadership Fellow.
Faculty at the Bindley Bioscience Center (BBC), the Birck Nanotechnology Center (BNC), and the
Purdue Center for Cancer Research (PCCR). Purdue University, West Lafayette, IN

Develop and apply single molecule tools and nanoscale imaging platforms comprising of fluorescence, Raman, and plasmonics in live cell biomedical discoveries relating to epigenetics, phosphorylation, and biosecurity.

Concurrently assumed the role of Co-leader for PCCR’s (Purdue Center for Cancer Research) Drug Discovery and Molecular Sensing Core (one of the four cores of PCCR). Lead multidisciplinary research grants in breast cancer, organize workshops and student research presentations, and seek opportunities for graduate training / center / program grants in cancer research.

Interdisciplinary research bridges the gap between biomedical sciences and nanotechnology and establishes a synergistic theme between the three centers (BBC, BNC, and PCCR) at Purdue. Collaborate with faculty from over ten departments.

Co-director, Physiological Sensing Facility (PSF) at BBC, a collaborative core which serves as an interdisciplinary resource to engage scientists and engineers in collaborative multidisciplinary research to develop advanced biosensor technologies. PSF is an incubation, developmental, and testing facility where students and faculty collaborate to create solutions to real-world problems.

As Graduate Chair of ABE, oversee ~110 graduate students in a multidisciplinary program comprising of Biological Engineering (40%), Machine Systems Engineering (30%), Natural Resources Engineering (20%), and Food and Pharmaceutical Engineering (10%).

Co-PI, Center for Food Safety Engineering, USDA-Purdue University collaboration. Develop field deployable biosensors and portable Raman imaging and spectroscopic biosensors for onsite detection of foodborne pathogens.

ASSOCIATE PROFESSOR, Biological Engineering 2005 - 2009
Purdue University, West Lafayette, IN
Research focused on bionanotechnology with emphasis on nanomaterials as intracellular sensors and single molecule technologies to understand intracellular mechanisms related to cancer and neurodegenerative disorders. Senior Design project coordinator for ABE.

ASSOCIATE PROFESSOR, Applied and Engineering Physics 2004 - 2005
Cornell University, Ithaca, NY
One-year sabbatical in the Department of Applied and Engineering Physics. Developed collaborations with Dr. Harold Craighead’s group in single molecule methods to study enzyme kinetics and microflluidic approaches to cell sorting.

ASSISTANT PROFESSOR, Agricultural and Biological Engineering (ABE) 2002 - 2005
Faculty of Materials Research Institute, Pennsylvania State University, State College, PA
Developed Spectroscopic and Biosensor approaches for detecting pathogens and contaminants. Initiated university-wide biosensors program for multidisciplinary research. Co-led Engineering Research Center grants in Biospectroscopy.

ASSISTANT PROFESSOR, Agricultural and Biological Engineering 1998 - 2002
CO-DIRECTOR, Center for Food Manufacturing
Pennsylvania State University, State College, PA
Contributed to establishing a Biological Engineering program for teaching and research. Initiated a Biosensors program for detecting pathogens. Formed several international collaborative seed opportunities in spectroscopic research.

ADJUNCT FACULTY, Material Research Institute (MRI) 2000 - 2005
Pennsylvania State University. (Concurrently)
Developed bionanotechnology component and established a nanoscience laboratory for biology.
Established collaborative ties with Hershey Medical Center and other diagnostic campus centers.

Prior to 1998

Assistant Professor, Biological Engineering, Utah State University (USU). 1995 - 1998
Affiliate Faculty, USU’s Biotechnology Center.
First faculty hired to initiate research and teaching program in Biological Engineering.
Developed and taught a curriculum for the Biological Engineering graduate program including two new undergraduate and one new graduate course. Research: instrumentation and sensor development to study protein interactions in biomaterials.

Assistant Professor, University of Saskatchewan, Saskatoon, Canada. 1991 - 1994
Created and taught three new undergraduate and two new graduate courses in Engineering Mechanics, Systems Engineering, and Numerical Methods. Research: simulation and design of bioprocesses with an emphasis on understanding the biomechanical effects of heat and mass transfer in biological materials.

HONORS, AWARDS AND KEY PROFESSIONAL/SERVICE CONTRIBUTIONS

• Leadership Fellow (Committee on Inst. Cooperation-Academic Leadership Program), 2011
• University Faculty Scholar Award, Purdue University, 2010
• Award of Academic Excellence, Northeast Normal University, Changchun, China, 2009
• Seed for Success Award, Purdue University, 2006
• Bindley Bioscience Center, Executive Committee (2007 – Present)
• Bindley Bioscience Center Task Force and Strategic Planning Committee (2010)
• College of Engineering, Strategic Advisor Committee to the Dean (2009 – Present)
• Organizing Committee, Symposium on Breast Cancer Prevention, Rennes, France, 2011
• Chair, NIH Interdisciplinary Molecular Sciences and Training panel (2010-present)
• Panel member, NIH College of CSR Reviewers (2010 – 2012)
• Advisory Council, MBA Program, Maxvalue (India’s 1st online business school), 2009 - present
• Program chair of Bionanotechnology, IBE (2003-2004)
• USDA CSREES: Honor Award and Certificate, North East Multistate Research group, 2003
• Young Engineer of the Year, Northeastern region of ASABE, 2000
• Teacher of the Year award, Biological Engineering., Utah State University, 1997
• Innovation in Teaching award, Biological Engineering., Utah State University, 1997
• Best Paper awards
  o 2010 (ASME-IMECE Microfluidics 2010: Fluidics in Micro nanosystems)
  o 2008 (ASABE Superior paper award)
  o 2006 (ASABE Honorary mention)
  o 2004 (ASABE Superior paper award)
  o 2003 (ASABE Best paper Honorable mention)
  o Best Poster awards
   2007 (Sigma Xi, best student poster award, Purdue University)
   2002 (1st Prize, American Society for Microbiology poster competition)
   1993 (Best paper, R. J. Melosh medal awarded by Duke Univ.)
• David Ross Fellowship, Purdue University
• University Merit Scholarship, College of Agric. Engineering, TNAU, India

CURRENTLY ONGOING RESEARCH PROGRAMS

• Biomedical	Title	Collaborators
  Epigenetics - basic	In vivo epigenetics tools development to detect chromatin modifications at specific loci in single cells.	Irudayaraj, Kirchmaier (BCHM), Lossie (Animal Sciences)
  Epigenetics - basic	Assess the effect of alcohol on DNA methylation in Neural Stem Cell Differentiation	Irudayaraj, Zhou (Anatomy, IU School of Medicine)
  Epigenetics – cancer, basic	Investigate the dynamics and role of hydroxymethylcytosine in stem cells (neural, embryonic, and glioblastoma)
  Epigenetics - cancer	Quantification of epigenetic modifications in 3D tissue culture models and tissues	Lelievre (BMS) and Irudayaraj
  Epigenetics - cancer	Effect of nutrition on epigenetic modifications and its role in gene expression in embryos	(Karen Lillycrop, Univ. Southampton, UK)
  Phosphorylation - cancer	Detection of phophorylation in live single cells using surface enhanced Raman spectroscopy (SERS) and lifetime imaging	Irudayaraj and Parker (Medicinal Chemistry and Molecular Pharmacology, MCMP)
  Neurodegenerative – Parkinsons, Alzheimers	Live cell monitoring of alpha-synuclein aggregation and secondary structure formation by enhanced Raman and single molecule spectroscopy	Irudayaraj and Rochette (MCMP)
  DNA repair- cancer	Two-photon induced DNA damage and evaluation of the dynamics of NuMA in the nucleus and protein recruitment in living cells	Irudayaraj and Lelievre (BMS)
  Cancer	In vivo detection of mRNA and microRNA in single cells and tissues by plasmon and second harmonic general imaging (live cell transcript quantification)	Irudayaraj, Badve (Clarion IU School of Medicine) and Kirchmaier (BCMH)
  General – device development	Reverse Electrokinetic Pattering in biology: Motility studies, Chorum sensing, and cell sorting	Steve Wereley (ME) and Irudayaraj
  General	Indo-US Center for Cellular Engineering for biomedical research	Irudayaraj and Rao, CCMB (Hyderabad, India) [Dr. Irudayaraj and Rao are Co-directors]
  Environmental	Title	Collaborators
  Bioremediation	Mapping chromate/arsenate reduction sites in single bacterium by SERS	Irudayaraj, Nakatsu (AGRY), and Thompson (Biological Sciences, University of Tennessee)
  Plant Epigenetics	Detection of rare splice variants, noncoding RNAs, and epigenetic regulation in plants using Raman imaging and single molecule fluorescence (screening for energy efficient and disease resistance characteristics)	Irudayaraj and Schulz (HORT)
  Biosecurity	Nanobiosensors for pathogen detection	Irudayaraj
  Instrumentation	Title	Collaborators
  	Second harmonic generation and imaging at super-resolution scale	Irudayaraj
  	Development of a hyperspectral plasmon scanning workstation	Irudayaraj
  	Major research instrumentation for the development of high speed Hyperspectral Raman imaging instrumentation – Design of a portable Raman imaging system	Ben-Amotz (Chemistry) and Irudayaraj
  	Probe-based single molecule fluorescence correlation spectroscopy	Maiti (TIFR, India) and Irudayaraj
  	Major research instrumentation for the acquisition of multiphoton laser for ultrafast dynamics	Lucht (Mechanical Engineering), Irudayaraj, and 3 other Co-PIs

*[MCMP: Medicinal Chemistry and Molecular Pharmacology; BCHM: Biochemistry; BMS: Basic Medical Chemistry; HORT: Horticulture; ME: Mechanical Engineering; AGRY: Agronomy; TIFR: Tata Institute of Fundamental Sciences; CCMB: Center for Cellular and Molecular Biology

CENTER RELATED EFFORTS AND INVOLVEMENT

• Center for Nucleus Science and Engineering – A Purdue University initiative to create a Center on “Nucleus” science and engineering with a significant focus on epigenetic research. (PI: Irudayaraj, Co-PIs: Kirchmaier, Lelievre, Ozan, Zhou, Briggs, Lossie). A cluster hire was proposed by the sub-group and 5 faculty positions were granted by the VP’s office.
• Center for Food Safety Engineering grant (Purdue-USDA-ARS) on “Innovative Pathogen detection and characterization technologies for food safety” $1.14 million/year (2011-2016) (PI: Linton; Co-PIs: Ladisch, Bhunia, Irudayaraj, Applegate, Bashir). (funded)
• Indo-US Knowledge Science and technology Forum – Knowledge Network grant on “Center for Nanomedical and Cellular Engineering” (Co-Directors: Irudayaraj and Rao) ($120k)
• An NIH-P41 grant (Biomedical Engineering Technology development) for $3.75 million (due May 25th) to create a Center on Novel technologies for Cancer Epigenetics” is being planned (PI: Irudayaraj; Co-PIs: Kirchmaier, Lelievre, Zhou, Briggs. (planning for submission in May 2012)

GRANTS AND CONTRACTS

Grants Ongoing [Collaborative ongoing grants total ~$9 million. Funding since 2005, total ~$14 million]

*PCCR: Purdue Center for Cancer Research (NIH funded); CTSI: Clinical Translation & Sciences Institute (NIH funded)

Selected Grants Completed (last five years)

Teaching grants awarded (selected five grants)

INTELLECTUAL PROPERTY

Patents submitted
Full Application

• 64892.P1.US - Identity Profiling of Cell Surface Markers - An Application for a full US patent was filed in July 2008. (Inventor: Joseph Irudayaraj).

Provisional

• Sensitive detection of biomolecules and threat agents by signal amplification using nanoparticles. 2012. PRF Reference Number: 66014.P1.US Application Number: 61/578,283
• Abl kinase Raman biosensors for single cell phosphorylation detection. Invention disclosure filed Nov 15th 2011.
• 65218.P1.US – Single cell nanotools for in vivo analysis of chromatin components and gene expression. Provisional patent filed on Dec 15th, 2008.
• 64803.P1.US - Multiplex Biosensor Using Gold Nanostructures. Provisional patent application filed on Feb 23rd, 2007.
• 64892.P1.US - Identity Profiling of Cell Surface Markers. Provisional patent filed on July, 2007.
• C. 90063. PRF. Irudayaraj, J. and K. Haghighi. 1990. "GRAINFEM Software".

INSTITUTIONAL / NATIONAL COLLABORATIONS AND ENGAGEMENTS
Purdue University

Active Collaborations

1. Bioochemistry: Ann Kirchmaier: Developing tools for single living cell epigenetic analysis and basic studies on chromosomal segregation (three NSF, one PCCR, two CTSI, an IUPUI-Purdue NIH center grants are awarded; 2009-present). A KECK foundation grant is awarded ($1.75 million).
2. Basic Medical Sciences: Sophie Lelievre: A multiPI NIHR01 for $3.5 million is in review to develop tools to assess epigenetic modifications in select apical polarity genes and its positioning. Current efforts focus on exploring epigenetic modification events in 3D cell cultures.
3. Anatomy (IU School of Medicine): Feng Zhou: Key collaborator in the KECK foundation grant. Focus is on elucidating epigenetic mechanisms and loci specific detection of DNA methylation and hydroxymethylation in neural stem cells.
4. Biomedical Engineering: Akkus Ozan: Diagnosis of crystal-based arthopathies via Raman spectroscopy (an NIH-R01 was awarded in July 2011).
5. Medicinal Chemistry and Molecular Pharmacology: Laurie Parker: In vivo phosphorylation mapping in single cells using peptide biosenosrs (a DoD grant and an NIH-NCI/IMAT is awarded). Chris Rochett: Single molecule studies of alpha synuclein in living cells to elucidate the structure of protein on nanoparticles (NIH-R01 proposal is in review; $1.8 million).
6. Chemistry: Dor Ben-Amotz: Hyperspectral Raman imaging (NSF-IDBR grant is in progress)
7. Department of Horticulture and Landscape Architecture: Burkhard Schulz: Nanoscale approach to molecular marker assisted plant breeding is in progress. (NSF grant in progress)
8. Biological Sciences: Dorothea Thompson: An NIH-RO1 for ~$980k is in progress (2009-2012) to study metal reduction sites in single pathogens.
9. Agronomy: Cindy Nakatsu: Collaborative work on detection of metals in bacteria is in progress. Chromate and Arsenate reduction in Arthobacter is in progress.
10. Veterinary Science: Rebecca Packer: Targeted delivery of liposomal particles for brain tumor therapy. Preliminary research is in progress to submit an R21 in Feb 2012. This will be expanded to assess the epigenetic state of glioblastoma cell lines. (2011 - present)
11. Food Science: Lisa Mauer: Co-PI on Center for Food Safety Engineering grant (2007-present).

1. Mechanical Engineering: Steven Werleey: Reverse Electrokinetic Patterning (REP) for label-free sorting and chemotaxis studies. An NSF proposal on “REP to study chemotaxis” is in review. Collaboration with Tim Fisher’s group on spectroscopic analysis of graphene structures
2. Physics: Yong Chen: Graphene nanosensors (a review article is in progress, 2009-present)

Other U.S. Universities

• Iowa State University: Dr. Chenxu Yu: Pathogen Biosensors.
• IUPUI: Hari Nakshatri (Department of Surgery): Multiplex detection of cell surface markers; Drs. Sunil Badve (MD) and George Sledge (MD) on tissue identity profiling.
• Hershey Medical Center: Kristin Eckert (Dept of Biochemistry). Cancer detection
• Penn State University: David Allara (Dept. Chemistry – Functionalization protocols for disease diagnosis); Ali Demirci (Infrared and UV heating for pathogen inactivation); Dr. Debroy, Director of E. coli Center (Biosensors for food security)
• Cornell University: Harold Craighead (Applied and Engineering Physics): Fluorescence Correlation Spectroscopy for single molecule interaction monitoring
• Marshall University: Ashok Vaseashta (Physics): Nanotechnology workshop
• USDA – Dr. Fratamico on microbial metabolomics (Eastern Regional Research Center, PA)
• Leigh University: Himanshu Jain: pathogen detectors

Industry Collaborations

Active

• Covidien Pharmaceuticals (Hazelwood, MO) (2010 – present)
  o Drug screening [a grant for $90,000 is being formalized]
• bioMerieux SA, France (2010-present)
  o Pathogen detection sensors (awarded $84,000)
• Amneal Pharmaceuticals Inc. (2012). In negotiation. Spectroscopic analysis of pharmaceuticals.
• NineSigma - Arch Chemicals (Contract in process for Phase I funding of $40,000, Phase II funding is $150,000). Contract is being negotiated by Purdue’s Industry Relations Office.

Past (last ten years)

• Perfint Inc. (Chennai, India)
  o Nanoparticle-based drug delivery
• Millipore Inc. (2008)
  o DNA quantification methods using Raman spectroscopy
• Ocean NanoTech Inc. Fayetteville, AR
  o Magnetic particle synthesis for multifunctional nanosensors
• Aetos technologies (Darkfield microscopy) (2007)
  o Extension of Darkfield microscopy for cancer detection
• Dow Agrosciences, Indianapolis, IN. Industry visit and seminar (2007)
  o Biosensor development for plant species differentiation
• Lynntech Inc. (Dallas, TX) (Detection Technologies) (2006)
  o Development of a Pathogen detector by mid-infrared spectroscopy
• Nestle Corp. Switzerland (Food characterization research) (2004)
  o Examination of lipid interaction using spectroscopy in chocolates
• CSO Analytical Instruments, Reichert Inc., NJ. (Research equipment funding) (2003)
  o Surface Plasmon Resonance based sensors for pathogen detection
• Evident Technologies (Quantum dots for food and health) (2003)
  o Tagging proteins with quantum dots – donation of quantum dot samples
• Xenon Corp., MA (Pulse UV research equipment) (2003)
• Electronic Sensor Technology, CA. (Sensor methods and protocol development) (2002)
  o Aroma sensor development – methodology development

International Collaborations and engagements

Ongoing

UK
Karen Lillycrop (University of Southampton, UK). Epigenetic programming due to folate uptake in fetal development.
Adele Murrell (Cambridge Research Institute, UK). Transcript measurement of select genes relating to methylation and hydroxymethylation during development. (in discussion).
India
An Indo-US Science and Technology forum network proposal on “Nanomedical and Cellular Engineering” is funded (2010-2012) in collaboration with the Center for Cellular and Molecular Biology (CCMB, Hyderabad). Eight exchange (student) visits are planned.
Italy
A visiting professor grant by the University of Sassari is awarded to develop a collaborative program with the Nanotechnology Institute (Dr. Greppi) in Sassari for biosensor development. A visit was completed in Summer 2011. A second visit is in the planning stages during Summer 2012.
Brazil
A federal grant (Brazil) to initiate collaboration with US scientists was awarded (PI is Adriana
Franca, Mechanical Engineering, University of Minas Gerias). A 1-credit course on “Spectroscopy
and biosensors” was offered as part of my instructional effort (attended by 15 students).
China
Visitor exchange with the Chinese Academy of Sciences (Changchun) for nanomaterials research.
At present two CSC scholars conduct research in my lab.

Past Five Years

India
Dr. Sudipta Maiti from Tata Institute of Fundamental Research (TIFR). (ii) Dr. Venkatraman and Clinician Dr. Roy from M.G. Ramachandra Medical College (Chennai) are collaborating on RF mediated ablation therapy.
China
Beijing University, Dept. Chemistry, Dr. Li Na. Instructional efforts on Biosensors and nano materials.
Israel
Collaborations with Dr. Jelinek’s group (Head, Dept of Chemistry, Ben Gurion University). Proposal (BSF, Vaadia postdoctoral fellowship) on biomemitic calorimetric biosensors (awarded 2007).
Korea
Dr. Irudayaraj is a member of the “Nanomedicine” collaborative team that was awarded a 5-year $10 million award between Korean Institute of Science and Technology and Purdue. Collaborating on nanorod sensing methods [2007-2012].
Belgium
Collaborated with Dr. Bart Nicolai’s group from the Catholic University in Leuven in the area of spectroscopic biosensors. Graduate course development in Biosensors (ABE 560) with Dr. Lammertyn in the MEMS Laboratory in Leuven.

INSTRUCTION

Purdue University (2005 – present)

• ChE 320, Statistical Modeling and Quality Enhancement. [Spring’12]
• ABE 450, Finite Element Analysis in Design, Co-taught with Stroshine, 50% effort [Average Instructor rating: 4.1; Course rating: 4.0]
• ABE 485, Agricultural and Biological Engineering Senior Design [Average Instructor rating: 4.0; Course rating: 4.0]
• ABE 560/BME 521, Biosensors: Fundamentals and Applications. Co-taught with Rickus and Porterfield, 33% effort [Average Instructor rating: 3.5; Course rating 3.7]
• ABE 591T, Biophysics – an introduction, 100% effort (new course). [Average Instructor rating: 4.3, Course rating: 4.5]
• ABE 591I, Computational methods in biological engineering, 100% effort (new course)
• BME 695S, Single molecule methods, 100% effort
• ABE 697, Graduate Seminar, 25% effort

International Teaching Efforts

• Federal University of Minas Gerias, Bele Horizonte, Brazil, Department of Mechanical Engineering, 1 credit course on “Spectroscopy and Biosensors”, October 2010.
• Beijing University, Department of Chemistry, 1 credit course on “Biosensors”, June 2009.

New Courses developed in Institutions prior to Purdue (1991-2005)
The Pennsylvania State University (1998 – 2004)

• Introduction to Bionanotechnology, Spring 2004
• Introduction to Biosensors, Fall 1999, 2000, 2002, 2003
• Instrumentation and Measurements, Spring 1999, 2000, 2001, 2002, 2003, 2004).

Utah State University (1995 – 1997)

• Principles of Biochemical Engineering, Spring 1998
• Bioprocess Engineering, Fall 1995, 1996, 1997
• Finite Element Analysis for Engineers and Scientists, Spring 1996, 1997

University of Saskatchewan (1991 – 1994)

• Added-value Processing, Spring 1992, 1994
• Principles of Structures and Structural Design, Spring 1992, 1993, 1994
• Systems Engineering, Fall 1991, 1992, 1993, 1994
• Advance Finite Element Methods, Fall 1991, 1992, 1993
• Numerical Methods, Spring 1993

RESEARCH MENTORING

UNDERGRADUATE RESEARCH MENTORING

Purdue University (last 5 years)

• Andrew Antis, BS Biological Engineering, 2011 – Design of Single cell separation instrumentation.
• Christina Millhouse, BS Biological Engineering, 2011 - Basic Molecular biology techniques.
• Hyunwoo Chung, BS Biological Engineeirng, 2010 - MRI and PET imaging.
• Josue Ordaz, BS Biological Engineering, 2010-present, FEELS program, “Technology for detecting epigenetic modifications”.
• Zach Mcbride (SROP and CIC undergrad from Mirian University), 2011 Summer program. “Quantum dot diffusion dynamics in single living cells”, using FCS.
• Melinda Steffey, BS Biochemistry, 2010-2011, “Molecular biology methods in FISH”.
• Chan Soo Park, BS Physics, 2010-2011, “Understanding nanoparticle aggregation”
• Whitney Williams, BS Biological Sciences, 2010-2011, “Epigenetic modifications – an introduction”.
• Brett Marsh, BS Chemistry, 2010, “Nanoparticles for biosensing”.
• Ko Seong, BS Electrical Engineering, 2009-2010, Discovery Undergraduate Research Internship (DURI), Multiplex ion sensing in blood serum.
• Lisa Bartkowiak, BS Agric. and Biol. Engineering, DURI 2009, Detection of metal ions in bacteria.
• Tasneem Pishori, BS Biomedical Engineering, DURI 2008, Gold nanorod sensors.
• Pelin Cox, BS Chemical Engineering, DURI 2008, Biosensors.
• Sanjay Thakrar, BS Biomedical Engineering, DURI 2007-08, Nanosensors for biomedicine.
• Nilesh Badve, BS Material Science and Engineering, Summer Undergraduate Researcher. Fellowship (SURF 2007) program, Synthesis of Core-Shell particles as sensor materials.
• Jordan Heim, BS Physics, DURI 2007, Intracellular quantification of drugs, Pursuing Ph.D in Cornell University (one manuscript published in Chem Phys Letters).
• Leonard Kim, BS Agricultural and Biological Engineering, DURI 2006, NanoSPR concept for microorganism detection.
• Lauren Hamamoto, BS Biomedical Engineering, DURI 2006, Raman spectroscopy for detecting cancer.
• Matt Zikerlbach, BS Health Sciences, DURI 2006, Intracellular SERS monitoring, In Medical School
• Xiaoda Yuan, BS Agricultural and Biological Engineering, DURI 2006, Single molecule microscopy for protein interaction.
• Funian Xiao, BS Electrical and Computer Engineering, DURI 2006, SPR instrumentation design and validation. (ECE program)

GRADUATE STUDENT MENTORING

Purdue University

Graduate Students Supervised Prior to Purdue (PSU: The Pennsylvania State University; USU: Utah State University; USASK: University of Saskatchewan): 9 PhDs and 11 MS

POSTDOCTORAL SCHOLARS MENTORING

MENTORING OF INTERNATIONAL SCHOLARS AND VISITORS

SERVICE TO THE UNIVERSITY

Graduate Chair of Agricultural and Biological Engineering (ABE), the #1 ranked (2009, 2010, 2011) ABE graduate program (~110 graduate students). Contributed toward the development of new Biological Engineering & Technology (BET) graduate program, which currently has over 35 graduate students. Instrumental in developing an interdisciplinary Biological Engineering training group as part of the Purdue Life Sciences Graduate program. Co-led a core group of faculty in Biological Engineering to develop and finalize a curriculum for an approved undergraduate degree program.

Play a key administrative service role through my involvement with the Strategic Advisory Committee to the Dean (College of Engineering), to provide critical evaluation of the blue skies plan and assessment of the strategic direction to improve the ranking of the college.

Invested extensively in Purdue’s Discovery Park operations and represented my department and the college both at the Bindley Bioscience Center (BBC) and the Birck Nanotechnology Center (BNC). Through the co-directed Physiological Sensing Facility, my students and I have generously donated our time to promote biological engineering research and educational efforts to the public through Discovery Park organized tours and symposiums. As a member of the Task Force Committee to the BBC we provide a strategic vision in consultation with an external evaluator. Co-lead the Breast Cancer Discovery Group and core member of the International Breast Cancer Prevention Committee. The task of our think tank committee is to provide a global vision on breast cancer prevention. Participated in faculty search committees across disciplines as well as in the College Promotion and Tenure committee.

Major committee assignments in the Department, School and / or University at Purdue

Department Committees

• Graduate Chair, ABE (2009 – Present)
• Co-Chair, Biological Engineering Curriculum Committee (2010-Present)
• Awards Committee, ABE (2005 – Present)

College Committees

• College of Engineering, Strategic Advisor Committee to the Dean (2009 – Present)
• College of Engineering Curriculum Committee (2007 – 2011)
• College of Engineering Graduate Committee (2009 – Present)
• College of Agriculture Graduate Council (2009 – Present)
• Advisory Board, Life Sciences Microscopy Facility (2010 - Present)
• College of Agriculture, Outcome Based Program Improvement Committee, 2008
• Faculty Affairs Committee (2006 – 2010)

University/Discovery Park Committees

• Bindley Bioscience Center, Executive Committee member (2007 – Present)
• Bindley Bioscience Center Task Force (2010)
• Bindley Bioscience Center Safety Committee (2007 – Present)
• Other
  o Physiological Sensing Facility, Co-director (2005-Present)
  o BioNanoTechnology Program (BNTP)/Nanomedicine Development Center (NDC) seminar series, Chair (2006-2007)
  o Biophysics Core, Bindley Bioscience Center (2006-Present)
• Full member, Purdue Center for Cancer Research (2006-Present)
  o Core-Committee member, International Breast Cancer Prevention (IBCN)
  o Co-Leader, Breast Cancer Discovery Group, PCCR (2010-Present)
• Full member, Birck Nanotechnology Center (2008-Present)
• Endowed Chair faculty search committee in Cancer Therapeutics, Medicinal Chemistry and Molecular Pharmacology (2008)

Other Campus-wide Initiatives

• Multicultural diversity forum workshop. April, 2007. Purdue University.
• Faculty advisor, Minority Students Apprenticeship Program (Penn State, 2000)
• Freshman and inter-department seminars (six 45-minute sessions/year) (1999-2004)
• Freshman advising (six 3-hour advising activities/year, Penn State (1999 – 2004)
• Freshman Women in Engineering Forum, Penn State (1999 – 2004)
• Faculty Social Activities Committee, Penn State (1999-2003)
• Faculty Advisor, European Students Club, Penn State (2000-2003)

SERVICE TO THE PROFESSION

Serve and represent my profession both at the national and international level. Standing member of the NIH’s NANO panel (2007-2010) and generously assisted the ARRA panels in reviewing both Transformative Research and Challenge Grants. Invited to become a member of NIH’s new College of CSR Reviewers (2010-12). Currently chair NIH’s Interdisciplinary Molecular Sciences and Training Panel.

Review NSF and DOE Career grants. Serve on numerous adhoc reviews for NSF, NIH, DOD, and Susan Komen Foundation. Serve on six journal editorial boards and contribute time to programs both within and outside the U.S.; e.g. USDA: nanotechnology program and Biosystems in Belgium.

Developed a substantial collaborative research network base among colleges, which has proven to be extremely useful in training students in cross-disciplinary skills among the collaborating laboratories. The ultimate result is to provide diversity in experience to Purdue engineers and scientists.

I actively reach out to students in the middle and high schools to explain the meaning and role of Biological Engineering. As an outcome of such efforts, Ms. Neha Ramani, an 8th grader who worked in my lab on “Tumor targeting nanoprobes” won the Gold Medal in her Junior Division (7th and 8th grade) as well as the Purdue Cancer Center Award, College of Science Dean’s award and the Eli Lilly Labs Trophy in 2009. Ms. Arthi Puri won (7th grader) was placed second in 2010 science fair. At present she is continuing her research in epigenetics as a Science fair competition project for 2011.

At present two high schools students and four undergraduate students are involved in bioNanotechnology related research in my laboratory. Other outreach activities include participation in the Minorities education program and the Summer school program for high school students.

Grant Review

• Chair, NIH Interdisciplinary Molecular Sciences and Training panel (2010-present)
• Panel member, NIH College of CSR Reviewers (2010 - 2012)
• Panel member, NIH Single Cell Analysis, Special Review Panel (2011 – present)
• Panel member, NIH Bioengineering Sciences and Technology (2011-present)
• Panel member, NIH-Nanotechnology-M(01), Study section member (2007-2010)
• Panel member, NIH SBIR ARRA Study Section, (2009 - present)
• Panel member, NSF SBIR (Biological Instrumentation & Biomedical Devices) (2008-present)
• Panel member, Susan Komen Foundation, Postdoctoral Fellowship program (2011-present)
• Panel member, DOE Career grant, Advanced Instrumentation Program (2011)
• Panel member, DOD, CDMRP Idea grants for the Prostate Cancer program (2009)
• Panel member, USDA- NRI, Food Characterization and processing, (2002, 2003)
• Panel member, National Academies, Pathogen/Disease Detection program (2008)
• Panel member, Department of Homeland Security, Institute of Defense, Biothreat agents (2004)
• Ad hoc Reviewer
  o Several NSF, NIH, DoD, DARPA, USAMRMC programs
  o NSF International Collaborative grants program (2007)
  o USDA NRI and SBIR panels (2004-Present)
  o American Association for Advancement of Science
  o Singapore Biomedical Research Council, Agency for Research, and Technology
  o Medical Research Council (UK, 2008-present); NSERC (Canada, 1995-present)
  o Bilateral Science Foundation (US-Israel); BARD (US-Israel) (2004-Present)
  o European Agricultural Research Agency (2006-2007)

Journal Editorial Board

• Editorial Board, Journal on Nanotube Therapy
• Editorial Board, Journal of Pediatric Biochemistry, publishes articles in pediatric medicine and biochemical aspects to study childhood diseases in body fluids, cells or tissues. (2009-present)
• Journal of Molecular Imaging and Dynamics, OMICS Publishing group (2010-present)
• Editorial Board, Research Letters in Nanotechnology. Hindawi Publications. Aspects of Nanoscience and technology applied to cancer (2008-present)
• Journal of Cancer Nanotechnology: Basic, Translational, and Clinical research” Springer-Verlag. Associate Editor (2009 – present)
• Editorial Board, Pathogen Sensors. Special Edition of Sensors Journal (2008-2009)
• Editorial Board, Sensing and Instrumentation for Food Quality (2008-present)
• Editorial Board, The Open Biomarkers Journal, Betham Science Publishers (2008 – present)

Journal manuscript Peer Review (Review at least 2 articles/month):

• Angewandte Chemie
• ACS Nano
• Nano Letters
• Nature Nanotechnology
• JACS
• Advanced Materials
• J. Physical Chemistry
• Nanomedicine
• Analytical Chemistry
• European Journal of Chemistry
• Langmuir
• J. Chemical Physics
• Biophysical Journal
• Vibrational Spectroscopy
• Talanta
• Biopolymers
• Anal Chem. Acta
• Biosensors and Bioelectronics
• Lab on Chip
• J.Molecular Structure
• Applied Spectroscopy
• Trans of ASABE

MEMBERSHIP IN PROFESSIONAL SOCIETIES

Society Memberships

1. member, American Chemical Society (2007-Present)
2. member, Biophysical Journal Society (2008 – Present)
3. member, SPIE (2006-Present)
4. member PITTCON (2007-Present)

Institute of Biological Engineering (member, 2003-Present)

1. Program chair of Bionanotechnology, IBE (2003-2004)
2. Elected council member at-large, IBE (2006-2007) (member, 2007-Present)

International program activities

1. Organizing Committee, Symposium on Breast Cancer Prevention, Rennes, France, Oct’11
2. Panel Member, Review of Departments and research programs in the College of Science and Technology (a 15 member panel selected internationally), Sept’11
3. Advisory Council, MBA Program, Maxvalue Online (India’s first online business school), 2009 - present
4. Advisory Panel, International Drying Symposium, Advisory Panel (2004), India
5. Organizing Committee: International Conference on Micro and nanotechnologies ICMNT 2006, Tizi-Ouzou, Algeria, 19-23 Nov, 2006. Organizing Committee

American Society of Agricultural and Biological Engineers

1. Associate Editor, IET Division, ASAE (1997-2001)
2. Executive Committee (FPE-01) (2000-2005)
3. Steering Committee (FPE-02) (2000-2005)
4. International Meetings Committee (E-10) (2000-2005)
5. General Programs Committee, Vice Chair (FPE-06) (2002-2003)
6. Biosensors Committee, Chair (BE 23) (2003-2004)

Regional Committee participation

1. North Central 1031 Biosensors and Nanotechnology Regional Project, Chair (2005-2006)

CERTIFICATION

Engineer in Training, Saskatchewan, Canada, 1992

COMMUNITY INITIATIVES

Member, International Breast Cancer Prevention and Nutrition advisory group: work closely with local hospitals. Perform analysis of hospital samples, monitor progression of certain diseases, and contribute articles to cancer communication materials. I have over the years presented several lectures to high schools on the importance of Biological Engineering. I have also hosted high school students in our laboratory at the Bindley Bioscience Center to teach the basics of biospectroscopy.

Volunteer, Special Olympics, Winter games 1992, Saskatoon, Saskatchewan; Volunteer, UNICEF,
Saskatchewan, Canada (1992)

SCHOLARLY PUBLICATIONS AND PRESENTATIONS

PUBLICATIONS

Peer Reviewed Manuscripts
Articles in Revision/Review

1. Lee, K. and Irudayaraj, J. 2012. Raman nanorulers in detection, quantification, multiplexing, and distance measurement. ACS NANO. (In Revision)
2. Liu, J., and Irudayaraj, J. 2012. Second Harmonic Generation Correlation Spectroscopy for single molecule experiments. Optics Express. (In Review)
3. Butler, F., Husk, T., Chen, J., Irudayaraj, J., Colby, R., Stach, E., Bashir, R., and Bergstrom, D. 2011. Peptide nucleic acid assembly. JACS. (In Revision)
4. Dong, C. and Irudayaraj, J. 2012. Hydrodynamic size dependant cellular uptake of aqueous QDs probed by fluorescence correlation spectroscopy. J. Phys Chem. (In Revision)
5. Ravindranath, S., Thompson, D., and Irudayaraj, J. 2012. Intracellular gold nanoislands as SERS substrates for monitoring chromate, sulfate, and nitrate localization sites in S. oneidensis MR-1 biofilms. Analytica Chimica Acta. (In Review)
6. Stephen, K., Homrighausen, D., DePalma, G., Nakatsu, C., and Irudayaraj, J. 2012. Using Surface Enhanced Raman Spectroscopy (SERS) to discriminate between Arthrobacter strains based on variations in cell surface composition. Analysi (In Review)
7. Jae-Sung, K., Ravindranath, S., Aloke, K., Irudayaraj, J. and Wereley, S. 2012. Opto-electrokinetic manipulation technique for high-performance on-chip biological assay. Lab on Chip. (In Revision)

Articles in Preparation for Publication

1. Lee, K. and Irudayaraj, J. 2011. In vivo real-time quantification of intracellular mRNA using plasmon spectroscopy. Nature Nanotechnology.
2. Chen, J., Kirchmaier, A., and Irudayaraj, J. 2011. Profiling histone modification dynamics and patterns in live single cells. J. Cell Science.
3. Chen, J., Fan, X., Kirchmaier, A., and Irudayaraj, J. 2011. Demonstration of a 3-color FLIM-FRET concept in live cells. Biomedical Optics.
4. Dong, C. and Irudayaraj, J. QD trafficking in cells probes by single molecule methods. ACS Nano.
5. Cho, I. and Irudayaraj, J. 2012. In-situ immunogold nanoparticle network-based ELISA for biosensor for highly sensitive pathogen detection. Analytical Chemistry.

Selected publications (2005-present: Bioengineering/Biomedical Science) (career refereed publications: ~175) [Citations since 2007: 3100 (h-index: 32; i10-index: 91); Overall Citations: 3950 (h-index: 35)]

1. Chen, J., Miller, A., Kirchmaier, A., and Irudayaraj, J. 2012. Single Molecule Tools Elucidate H2A.Z Nucleosome Composition. J. Cell Science. (In Press, available online)
2. Wang, Y., Book, B., and Irudayaraj, J. 2012. Folic acid protected doxorubicin coated silver nanocarriers for targeted drug delivery. J. Biomedical Nanotechnology. (In Press)
3. Book, B. Wang, Y., and Irudayaraj, J. 2012. Multifunctional gold nanorods for targeted drug delivery using 2-photon excitation. Euro Journal of Medicinal Chemistry. 48:330-337.
4. Wang, Y., Chen, J., and Irudayaraj, J. 2011. Nuclear targeting dynamics of gold nanoclusters for enhanced therapy of HER2+ breast cancer. ACS NANO. 5(12):9718-9725.
5. Guo, C., Book, B., and Irudayaraj, J. 2011. Protein-directed reduction of Graphene oxide and intracellular imaging. Chemical Communications. 47(47):12658-12660.
6. Panchapakesan, B., Book, B., Seth R., and Irudayaraj, J. 2011. Gold nanoprobes for theragnostics and diagnostics. Journal of Nanomedicine, 6(10):1-7.
7. Lee, K., Drachev, V., and Irudayaraj, J. 2011. DNA-Gold nanoparticle networks grown at cell surface marker sites: Diagnostics of cancer stem cells. ACS NANO. 5(3):2109-2117.
8. Wang, Y. and Irudayaraj, J. 2011. A SERS DNAzyme biosensor for lead ion detection. Chemical Communications. 47:4394-4396.
9. Chen, J., Nag, S., and Irudayaraj, J. 2011. Single molecule in vivo analysis of Toll-like 9 and CpG DNA interaction. PLoS ONE. 6(4):e17991 (8 pages).
10. Ravindranath, S., Henne, T., Thompson, D., and Irudayaraj, J. 2011. Intracellular bioreduction of Chromate-decorated Gold nanoparticles by Shewanella oneidensis MR-1 by Raman chemical imaging. ACS NANO. 5(6):4729-36.
11. Guo, C. and Irudayaraj, J. 2011. Fluorescent Ag clusters via a Protein-directed approach as a Hg(II) ion sensor. Analytical Chemistry. 83(8):2883-9.
12. Ravindranath, S., Wang, Y., Irudayaraj, J. 2011. SERS driven Cross-platform based multiplex pathogen detection. Sensors & Actuators: B. Chemical. 152: 183-190.
13. Ravindranath, S., Henne, K., Thompson, D., and Irudayaraj, J. 2011. Surface-enhanced Raman Imaging of Intracellular Bioreduction of Chromate in Shewanella oneidensis. PLoS ONE. 6(2): e16634 (10 pages).
14. Mura, S., Corrias, F., Stara, G., Piccinini, M., Secchi, N., Marongiu, D., Innocenzi., P., Irudayaraj, J., and Greppi, G. 2011. Innovative composite films of chitosan, methylcellulose and nanoparticles. Nanoscale Food Sci., Engineering & Technology. J. Food Science. 76(7):N54-N60.
15. Wang, Y., Ravindranath, S., and Irudayaraj, J. 2010. Separation and detection of multiple pathogens in a food matrix by SERS nano probes. Anal. & BioAnal. Chemistry. 399 (3):1271-8.
16. Rout, C., Kumar, A., Xiong, G., Irudayaraj, J., and Fisher, T. 2010. Au nanoparticles on graphitic petal arrays for surface-enhanced Raman spectroscopy. Applied Physics Letters. (vol. 97, art. no. 133108, 2010).
17. Book, B., Chen, J., and Irudayaraj, J. 2010. Quantification of receptor targeting aptamer binding characteristics using single-molecule spectroscopy. Biotechnology and Bioengineering (Online DOI: 10.1002/bit.23043). 108 (5):1222-1227.
18. Wang, Y., Seebald, J., Szeto, D., and Irudayaraj, J. 2010. Biocompatibility and biodistribution of surface-enhanced Raman scattering nanoprobes in zebrafish embryos in vivo and multiplex imaging. ACS NANO. 4(7):4039-53.
19. Chen, J. and Irudayaraj, J. 2010. Fluorescence lifetime cross correlation spectroscopy resolves EGFR and antagonist interaction in live cells. Analytical Chemistry. 82(15):6415-21.
20. Wang, Y., Lee, K., and Irudayaraj, J. 2010. Silver nanosphere SERS probes for sensitive identification of pathogens. J. Physical Chemistry C. 114(39): 16122-16128.
21. Miller, A., Takasuka, T., Chen, J., Kaufman, P., Jacobi, J., Irudayaraj, J., and Kirchmaier, A. 2010. PCNA Is Required for Cell-Cycle Regulated Silent Chromatin on Replicated and Nonreplicated Genes. J. Biological Chemistry. 285(45):35142-54.
22. Nag, S., Chen, J., Maiti, S., and Irudayaraj, J. 2010. Measurement of the attachment and assembly of small amyloid-beta oligomers on live cell membranes at physiological conditions using single molecule tools. Biophysical Journal. 99(6):1969-75.
23. Wang, Y., Lee, K., and Irudayaraj, J. 2010. SERS aptasensor from nanorod-nanopaticle junction for protein detection. Chem. Communications. 46(4):613-615.
24. Chen, J. and Irudayaraj, J. 2009. Quantitative investigation of compartmentalized dynamics of ErbB2 targeting gold nanorods in live cells by single molecule spectroscopy. ACS NANO. 3:4071-4079. (Featured in NIH-NCI Nanotech. alliance, January News and Science Daily)
25. Wang, C. and Irudayaraj, J. 2009. Multifunctional magnetic-Optical nanoparticle probes for simultaneous detection, separation, and ablation of multiple pathogens. Small. 2(6):283-289.
26. Kumar, V. and Irudayaraj, J. 2009. SERS in salt wells. Chemphyschem. 10(15):2670-2673.
27. Sun, L. and Irudayaraj, J. 2009. PCR-free quantification of splice variants in Cancer Gene using Surface Enhanced Raman Spectroscopy. J. Phys. Chem. 113:5980-5983.
28. Sun, L. and Irudayaraj, J. 2009. Quantitative Surface Enhanced Raman for gene expression estimation, Biophysical Journal. 96:4609-16.
29. Wang, C. Chen, J. Talavange, T. and Irudayaraj, J. 2009. Gold nanorod/Fe3O4 nanoparticle “Nano-Pearl-Necklaces” for simultaneous targeting, dual-mode imaging, and photothermal ablation of cancer cells. Angewandte Chemie, 121(15):2797-2801.
30. Chen, J., Wang, C., and Irudayaraj, J. 2009. Ultrasensitive on-step immunoassay in blood serum using gold nanoparticle probes by single molecule spectroscopy. Biomedical Optics Letters, 14(4). 040501.
31. Lee, K. and Irudayaraj, J. 2009. Periodic and dynamic 3-D gold nanoparticle-DNA network structures for surface-enhanced raman spectroscopy-based quantification. J. Phys. Chem. C. 113:5980-5983.
32. Ravindranath, S., Mauer, L., Chitrita, D., and Irudayaraj, J. 2009. Biofunctionalized magnetic nanoparticle integrated mid-infrared pathogen sensors for food matrices. Analytical Chemistry, 81(8):2840-2846.
33. Vidi, P., Chen, J., Irudayaraj, J. and Watts, V. 2008. Higher-order Adenosine A-2A receptor oligomers revealed by BiFC-FRET and FLIM. FEBS Letters, 582(29):3985-3990.
34. Yu, C., Jacob, R., Ritchie, K., Prasad, N., Irudayaraj, J. 2008. Receptor Overexpression or Inhibition Alters Cell Surface Dynamics of EGF-EGFR interaction: New Insights from Real-time Single Molecule Analysis. Biochemical and Biophysical Res. Communication, 378(3):376-382.
35. Bakker, R., Yuan, H., Liu, Z., Pedersen, R., Boltasseva, A., Chen, J., Irudayaraj, J., Kildishev, A., Drachev, V., and Shalaev, V. 2008. Nanoantenna induced fluorescence enhancement: dipolar coupling and reduced lifetimes. New Journal of Physics, 10:125022.
36. Sun, L., Yu, C. and Irudayaraj, J. 2008. Raman multiplexers for alternative gene splicing. Analytical Chemistry. 80(9):3342-9.
37. Wang, C. and Irudayaraj, J. 2008. Gold nanorod probes detects multiple pathogens. Small. 4(12):2204-2208.
38. Shamsaie, A., Heim, J. and Irudayaraj, J. 2008. Quantification of MBA in living cell by surface enhanced raman spectroscopy. Chemical Physics Letters, 461:131-135.
39. Varghese, L., Sinha, R., and Irudayaraj, J. 2008. Single molecule kinetic investigations of protein association and dissociation using fluorescence cross-correlation spectroscopy. Analytica Chimica Acta. 625(1):103-109.
40. Sarkar, T. and Irudayaraj, J. 2008. Carboxyl coated magnetic nanoparticles for mRNA isolation and extraction of supercoiled plasmid DNA. Analytical Biochemistry. 379:130-132.
41. Sun, L., Yu, C., and Irudayaraj, J. 2007. Surface enhanced Raman scattering based nonfluorescent probes for multiplex detection. Analytical Chemistry, 79(11):3981-3988. (Selected as a featured article “No-glow tags for Raman Spectroscopy” in June 1, 2007 issue)
42. Shamsaie, A., Irudayaraj, J. 2007. Intracellularly Grown Gold Nanoparticles (IGAuN) as Potential SERS Probes. Biomedical Optics. 12(2):020502-1-3. (Most frequently downloaded paper on the SPIE digital library, 2008)
43. Mizrach, A., Z. Schmilovitch, R. Korotic, J. Irudayaraj, and R. Shapira. 2007. Yeast detection in apple juice using Raman spectroscopy. Transactions of ASABE 50(6):1-8. (Superior paper Award, ASABE 2008 International meeting)
44. Yu, C. Naksharti, H., and Irudayaraj, J. 2007. Identity profiling of cell surface markers by multiplex gold nanorod probes. Nano Letters, 7(8): 2300-2306.
45. Yu C, and Irudayaraj J. 2007. A multiplex biosensor using gold nanorods. Analytical Chemistry. 79(2): 572-579. [2nd Most cited in Analytical Chemistry in 2007 and 5th Most cited as of 3/08]
46. Yu, C. and Irudayaraj, J. 2007. Sensitivity and Selectivity limits of multiplex nanoSPR biosensor assays. Biophysical Journal. 93:3684-3692.
47. Yu, C., Varghese, L., and Irudayaraj, J. 2007. Surface modification of CTAB capped gold nanorods to make molecular probes. Langmuir, 23: 9114-9119.
48. Kouassi, G., Wang, P., Sreevatsan, S., Irudayaraj, J. 2007. Detection of prion protein on streptavidin-aptamer mediated magnetic and gold-coated magnetic nanoparticles. Biotech Progress 23(5):1239-44.
49. Yu, C., Gestl, E., Eckert, K., Allara, D., Irudayaraj, J. 2006. Characterization of Human Breast Epithelial Cells by Confocal Raman Microspectrometry. J. Cancer Diagnosis and Prevention, 30(6):1-10
50. Beullens, K., Kirsanov, D., Irudayaraj, J., Rudnitskaya, A., Legin, A., Nicolai, B., and Lammertyn, J. 2006. The electronic tongue and ATR-FTIR for rapid detection of sugars and acids in tomatoes. Sensors and Actuators, B: Chemical, v 116, n 1-2, Jul 28, 2006, p 107-115
51. Gupta, M., Irudayaraj, J., Schmilovitch, Z., Mizrach, A. 2006. Quantification of foodborne pathogens in different food matrices using FTIR and artificial neural networks. Trans of ASABE 49(5):1249-1256.
52. Kouassi, G. and Irudayaraj, J. 2006. Magnetic and gold-coated magnetic particles as a DNA sensor. Analytical Chemistry. 78(10):3234-3241. [Top 10 most accessed article in 2006 in Analytical Chemistry (ranked 6th in the list); Ranked in the Top 100 (11th in the list) of Nanomedicine publications for 2006 by Ion Channel media group]
53. Kouassi, G. and Irudayaraj, J. 2006. A nanoparticle-based immobilization assay for prion-kinetics assay. Journal of Nanobiotechnology. 48(8):1-10. [Accessed 2026 times)
54. Kizil, R. and Irudayaraj, J. 2006. Discrimination of irradiated starch gels using FT-Raman spectroscopy and chemometrics. J. Agric. and Food Chemistry, 54(1):13-18. [Most accessed article in 01/06-03/06]
55. Yu, C. and Irudayaraj, J. 2006. Detection and identification of pathogenic microorganisms in mixed cultures by FTIR spectroscopy. Trans of ASABE, 49(5):1623-1632. [Honorary mention certificate at the 2007 ASABE meeting).
56. Waswa, J., Debroy, C., and Irudayaraj, J. 2006. Rapid detection of Salmonella enteritidis and Escherichia coli using the BiacoreTM Surface Plasmon Resonance biosensor. J. Food Process Engineering, 29: 373-385.
57. Waswa, J., Debroy, C., and Irudayaraj, J. 2006. Rapid detection of Salmonella enteritidis and Escherichia coli using the BiacoreTM Surface Plasmon Resonance biosensor. J. Food Process Engineering, 29: 373-385.
58. Yu, C., Ganjoo, A., Jain, H., Pantano, C., and Irudayaraj, J. 2005. Towards a mid-IR biosensor: Detection and fingerprinting of pathogens on chalcogenide films. Anal. Chem. 78(8):2500-2506.
59. Ganjoo, A., Jain, H, Song, R., Yu, C., Ryan, J., Irudayaraj, J., Ding, Y., and Pantano, C. 2005. Chalcogenide Glass Waveguides for IR Evanescent Wave Sensors. J. Noncrystalline Solids 352:584-588.
60. Swaminathan, A., Irudayaraj, J., and Ryan, T. 2004. Comparison of mono and dithiol surfaces on surface plasmon resonance biosensors for detection of Staphylococcus aureus.. Sensors and Actuators B, 114:192-198.
61. Schmilovitch, Z., Mizrach, A., Kritzman, G., Korotic, R., Irudayaraj, J., and Debroy, C. 2005. Detection of bacteria with low resolution raman spectroscopy. Trans of ASAE. 48(5):1843-50.
62. Vaseashta, A. and Irudayaraj, J. 2005. Nanostructured and nanoscale devices and sensors. Journal of Optoelectronics and Advanced Materials. 7(1):35-42.
63. Kouassi, G., Irudayaraj, J., and McCarty, G. 2005. Examination of Cholesterol oxidase attachment to magnetic nanoparticles. J. Nanobiotechnology. (3)1:1-9. [3rd most accessed article (all time) in J. Biomagnetic Research and Tech - download access hit of 13,234.]
64. Kouassi, G., Irudayaraj, J., and McCarty, G. 2005. Activity of glucose oxidase functionalized onto iron nanoparticles. J. Biomagnetism and Technology. 3:1.
65. Swaminathan, A., Irudayaraj, J., and Ryan, T. 2005. Self-assembled monolayer-based surface plasmon immunosensor for detection of E. coli O157:H7. Biosensors and Bioelec. 21(7):998-06.
66. Yu, C. and Irudayaraj, J. 2005. Spectroscopic characterization of microorganisms by FTIR microspectroscopy. J. Biopolymers. 77(6):368-377
67. Lammertyn, J., Verboven, P., Veraverbeke, E., Vermeir, S., Irudayaraj, J., and Nicolai, B. 2005. Analysis of fluid flow and reaction kinetics in a flow injection analysis biosensor. Sensors and Actuators B. 114(2):728-736.
    Other Publications
68. Davis, R., Irudayaraj, J., Reuhs, B., and Mauer, L. 2010. Detection of E. coli O157:H7 from ground beef using FTIR spectroscopy and Chemometrics. J. Food Science, 75(6):M340-M346.
69. Kathiravan, K., Tewari, J., Demirci, A., and Irudayaraj, J. 2010. Microscopic and Spectroscopic Evaluation of Inactivation of Staphylococcus aureus by Pulsed UV Light and Infrared Heating. Food and Bioprocess Tech. 3(1):93-104.
70. Rudnitskaya, A., Kirsanov, D., Legin, A., Beullens, K., Lammertyn, J., Nicolai, B., Irudayaraj, J. 2006. Analysis of apples varieties - comparison of electronic tongue with different analytical techniques. Sensors and Actuators, B: Chemical, v 116, n 1-2, Jul 28, 2006, p 23-28.
71. Krishnamurthy, K., Demirci, A., and Irudayaraj, J. 2007. Inactivation of Staphylococcus aureus in Milk Using Flow-through Pulsed UV-Light Treatment System. Journal of Food Science. 72(7):M233-M239.
72. Kizil, R. and Irudayaraj, J. 2007. Rapid evaluation and discrimination of γ-irradiated carbohydrates using FT-Raman spectroscopy and canonical discriminant analysis. J. Science of Food and Agriculture, 87(7):1244-1251.
73. Gupta M., Irudayaraj, J., Debroy, C., Schmilovitch, Z., Mizrach, A. 2005. Detection and Differentiation of Food Pathogens using FTIR and Artificial Neural Networks. Trans. of ASAE. 48(5):1889-1892.
74. Tewari, J. and Irudayaraj, J. 2005. Floral classification of honey using mid-infrared spectroscopy and surface acoustic wave based z-nose sensor. J. Agric. and Food Chem. 53(18):6955-6966.
75. Dixit, V., Tewari, J., and Irudayaraj, J. 2005. Quantitative and qualitative identification of industrial grade glycerol adulteration in selected commercial red wine using mid-infrared spectroscopy. Applied Spectroscopy. 59(12):1553-1561.
76. Yang, H., Irudayaraj, J., Paradkar, M. 2005. Characterization of different edible oils and fats by FTIR, FT-NIR and FT-Raman Spectroscopy. Food Chemistry. 93(1):25-32.
77. Veraverbeke, E., Lammertyn, J., Nicolaï, B., Irudayaraj, J. 2005. Spectroscopic evaluation of the surface quality of apple. Journal of Agriculture and Food Chemistry. 53(4): 1046-1051.
78. Gao, X., Heinemann, P., and Irudayaraj. J. 2005. Non-destructive Apple Bruise Detection with Raman Spectroscopy and its Virtual Instrumental System. Transactions of the Chinese Society of Agricultural Engineering. 21(3):130-133.
79. Beullens, K., Irudayaraj, J., Nicolai, B., Kirsanov, D., Legin, A., Lammertyn, J. 2004. Novel techniques for fast taste profiling of tomatoes. Communications in Agriculture Applied Biological Sciences. 69(2): 57-60.
80. Jun, S. and Irudayaraj, J. 2004. An integrated dynamic model for fungal spore inactivation by selective infrared heating. Transactions of the ASAE. 20(4):481-485.
81. Sivakesava, S., Irudayaraj, J., and Debroy, C. 2004. Differentiation of microorganisms by FTIR-ATR and FT-NIR spectroscopy. Transactions of the ASAE. 7(3):951-957. [Superior paper award, 2005, ASABE meeting]
82. Veraverbeke, E., Irudayaraj, J., and Lammertyn, J. 2004. Fast aroma profiling with zNose™: case study on honey adulteration. J. Science of Food and Agriculture. 85:243-250.
83. Tewari, J. and Irudayaraj, J. 2004. Quantification of saccharides in multiple floral honeys using fourier transform infrared micro-attenuated spectroscopy. Journal of Agriculture and Food Chemistry. 52:3237-3243.
84. Innawong, B., P. Mallikarjunan, J. Irudayaraj and J. E. Marcy. 2004. The determination of frying oil quality using Fourier transform infrared attenuated total reflectance. Lebensmittel-Wissenschaft und-Technologie. 37(1): 23-28.
85. Yang, H., Irudayaraj, J., Otgonchimeg, S., Walsh, M. 2004. Rheological study of starch and dairy ingredient-based food system. Food Chemistry. 86:571-578.
86. Ranjan, R,. Irudayaraj, J., Reddy, J., Mujumdar, A.S. 2004. Finite element simulation of stepwise drying of bananas. Journal of Numerical Heat Transfer. Part A. 45:1-16.
87. Lammertyn, J., Veraverbeke, E., and Irudayaraj, J. 2004. Surface acoustic wave based zNose™ technology for rapid aroma profiling of honey. Sensors and Actuators, 98(1):54-62.
88. Gupta M. Irudayaraj, J., and Debroy, C. 2004. Spectroscopic quantification of bacteria using Artificial Neural Networks. Journal of Food Protection. 67(11):2550-2554.
89. Jun, S. and Irudayaraj, J. 2004. An integrated dynamic model for fungal spore inactivation by selective infrared heating. Transactions of the ASAE. 20(4):481-485.
90. Yu, C., Irudayaraj, J., Debroy, C., Schmilovich, Z. and Mizrach, A. 2004. Spectroscopic differentiation and quantification of microorganisms in apple juice, J. Food Science, 70: S221-6.
91. Krishnamurthy, K., Demirci, A., Irudayaraj, J. 2003. Inactivation of Staphylococcus aureus by pulsed UV-light sterilization. Journal of Food Protection, 67 (5): 1027-1030.
92. Sivakesava, S., Bober, J., Irudayaraj, J., and Demirci, A. 2003. Spectroscopic determination of multiple components during nisin fermentation. CIGR Journal of Scientific Research and Development. Vol 4. Manuscript FP: 03 008 [ISSN 1682-1130].
93. Yang, H. and Irudayaraj, J. 2003. Rapid detection of foodborne microorganisms on food surface using Fourier transform Raman spectroscopy. Journal of Molecular Structure. 646: 35-43.
94. Jun, S., and Irudayaraj, J. 2003. A dynamic fungal inactivation approach using selective infrared heating. Transactions of the ASAE 46 (5): 1407-1412. [Best paper, 2004 ASABE meeting].
95. Jun, S., Irudayaraj, J., Demirci, A., and Geiser, D. 2003. Pulsed UV-light Treatment of Corn meal for Inactivation of Aspergillus niger. Journal of Food Science Technology 38: 883-888.
96. Tewari, J. and Irudayaraj, J. 2003. Simultaneous monitoring of organic acids and sugars in fresh and processed apple juice by FTIR-ATR spectroscopy. Applies Spectr. 57(12):1599-1604.
97. Paradkar, M. and Irudayaraj, J. 2003. Discrimination and classification of adulterants in maple syrup with the use of infrared spectroscopic techniques. J. Science of Fd. and Agric. 83:714-21.
98. Tewari, J., Mehrotra, R., and Irudayaraj, J. 2003. Direct NIR analysis of sugarcane clear juice using fiber optic transmittance probe. Journal NIR spectroscopy, 11(5):351-356.
99. Tewari, J., and Irudayaraj, J. 2003. Rapid estimation of Pol content in sugarcane juice using FTIR-ATR Spectroscopy. International Journal of Sugar Tech. 5(3):143-148.
100. Irudayaraj, J., Xu, F., Tewari, J. 2003. Rapid determination of invert cane sugar adulteration in honey using FTIR spectroscopy and multivariate analysis. J. Food Science. 68 (7):2040-2045.
101. Cho, B. and Irudayaraj, J. 2003. A non-contact ultrasound approach for mechanical property determination of cheese. Journal of Food Science. 68(7):2243-2247.
102. Cho, B. and Irudayaraj, J. 2003. Foreign object and internal defect detection in food materials using Non-contact ultrasound imaging. J. Food Science. April 2003, 68(3): 967-974.
103. Paradkar, M. and Irudayaraj, J. 2003. Discrimination and classification of adulterants in maple syrup with the use of infrared spectroscopic techniques. J. Science of Fd. and Agric. 83:714-721.
104. Kizil, R., Irudayaraj, J., and Seetharaman, K. 2002. Characterization of irradiated starches by FT-Raman and FTIR spectroscopy. Journal of Agric Food Chem. 50(14):3912-8.
105. Paradkar, M. and Irudayaraj, J. 2002. Determination of cholesterol in dairy products using infrared techniques: 1. FTIR spectroscopy. Inti. Journal of Dairy Technology. 55(3):127-132.
106. Yang, H. and Irudayaraj, J. 2002. Rapid determination of vitamin C by NIR, MIR and FT-Raman techniques", Journal of Pharmacy and Pharmacology. 54(9): 1247-1255.
107. Paradkar, M. and Irudayaraj, J. 2002. Determination of cholesterol in dairy products by infrared techniques: 2. FT-NIR method. International Journal of Dairy Technology. 55(3):133-138.
108. Jun, S. and Irudayaraj, J. 2002. Selective far infrared heating system design and evaluation (PART I). Drying Technology – An International Journal. 21(1): 51-67.
109. Jun, S. and J. Irudayaraj. 2002. Selective far infrared heating system applications and analysis (PART II). Drying Technology – An International Journal. 21(1): 69-82.
110. Ranjan, R., J. Irudayaraj, and S. Jun. 2002. Simulation of three-dimensional infrared drying using a set of three-coupled equations by the control volume method. Transactions of the ASAE. 45(5): 1661-1668.
111. Rajendran, V. and J. Irudayaraj. 2002. Detection of glucose, galactose, and lactose in milk with a microdialysis-coupled flow injection amperometric biosensor. J. Dairy Science 85:1357-1361.
112. Sivakesava, S. and J. Irudayaraj. 2002. Classification of simple and complex sugar adulterants in honey by mid-infrared spectroscopy. International Journal of Food Science and Technology. 37:351-360.
113. Cho, B. and J. Irudayaraj. 2002. Design and application of a non-contact air instability compensation ultrasound transducer using spatial impulse response. Transactions of the ASAE. 46(3):901-910.
114. Paradkar, M., Sivakesava, S., and J. Irudayaraj. 2002. Comparison of FTIR, FT-Raman, and NIR spectroscopy in a maple syrup adulteration study. Journal of Food Science. 67(6): 2009-2015.
115. Deshpande, S.D., S. Sokhansanj, and J. Irudayaraj. 2002. Effect of moisture content and storage temperature on respiration of Alfalfa. Biosystems Engin. 82 (1):79-86.
116. Paradkar, M. and J. Irudayaraj. 2002. Rapid estimation of caffeine content in soft drinks using FTIR spectroscopy. Food Chemistry. 78: 261-266.
117. Paradkar, M. and J. Irudayaraj. 2002. A Rapid FTIR Spectroscopic method for estimation of caffeine in soft drinks and Total methylxanthines in tea and coffee. Journal of Food Science. 67(7): 2507-2511.
118. Paradkar, M. and J. Irudayaraj. 2001. Discrimination and classification of beet and cane sugars and their inverts in maple syrup by FT-Raman. Applied Engineering in Agric. 18(3):379-383.
119. Irudayaraj, J. and S. Sivakesava. 2001. Detection of adulteration in honey by discriminant analysis using FTIR spectroscopy. Transactions of the ASAE 44(3): 643-650.
120. Cho, B. and J. Irudayaraj. 2001. Acoustic sensor fusion approach for rapid measurement of modulus and hardness of cheddar cheese. Applied Engineering in Agriculture. 17(6): 827-832.
121. Paradkar, M., J. Irudayaraj, and S. Sivakesava. 2001. Discrimination and classification of beet and cane inverts in different floral honey by FT-Raman spectroscopy. Food Chem. 76:231-239.
122. Sivakesava, S. and J. Irudayaraj. 2001. Prediction of inverted cane sugar adulteration of honey by FTIR spectroscopy. Journal of Food Science. 66(7): 972-978.
123. Sivakesava, S., J. Irudayaraj, and R. Korach. 2001. Detection of adulteration in apple juice using FTIR spectroscopy and multivariate statistical methods. Applied Engineering in Agriculture. 17(6):815-820.
124. Irudayaraj, J., H. Yang, and S. Sivakesava. 2001. Detection of microorganisms on food surface using Fourier transform photoacoustic spectroscopy. J. Molecular Structure. 606:181-188.
125. Cho, B., J. Irudayaraj, and M. Bhardwaj. 2001. A non-contact ultrasound technique for predicting mechanical properties of cheddar Cheese. Trans. of the ASAE. 44(6): 1759-1762.
126. Sivakesava, S. and J. Irudayaraj. 2001. Rapid detection of tetracycline in milk using mid infrared spectroscopy. Journal of Dairy Science. 85:487-493.
127. Yang, H. and J. Irudayaraj. 2001. Characterization of edible coatings and microorganisms on produce surface using depth profile analysis. Applied Spectroscopy 55(5):310-329.
128. Sivakesava, S. and J. Irudayaraj. 2001. Detection of inverted beet sugar adulteration of honey by FTIR spectroscopy. Journal of the Science of Food and Agric. 81:683-690.
129. Sivakesava, S. J. Irudayaraj, and A. Demirci. 2001. Monitoring a bioprocess for ethanol production using FT-MIR and FT-Raman spectroscopy. Journal of Industrial Microbiology and Biotechnology 26(4):185-190,196.
130. Sivakesava, S., J. Irudayaraj, and A. Demirci. 2001. Simultaneous determination of multiple components in lactic acid fermentation using Ft-MIR, NIR, and FT-Raman spectroscopic techniques. Process Biochemistry 37(4):371-378.
131. Yang, H. and J. Irudayaraj. 2001. Characterization of beef and pork using Fourier transform infrared photoacoustic spectroscopy. Lebebsm.-Wiss. u-Technology 34(6):401-408.
132. Sivakesava, S. and J. Irudayaraj. 2001. A rapid spectroscopic technique for determining honey adulteration with corn syrup. Journal of Food Sci. 66(6): 787-792.
133. Yang, H. and J. Irudayaraj. 2001. Rapid determination of olive pomace oil adulteration in extra virgin oil using NIR, FTIR, and FT-Raman techniques. Journal of American Oil Chemists Society 78: 889-895.
134. Cho, B. and J. Irudayaraj. 2001. Acoustic sensor fusion approach for rapid measurement of modulus and hardness of cheddar cheese. Applied Engineering in Agriculture. 17(6): 827-832.
135. Irudayaraj, J., S. Sivakesava, S. Kammath, H. Yang. 2001. Monitoring chemical changes in some foods using Fourier transform photoacoustic spectroscopy. Journal of Food Science 66(9):1416-1421.
136. Ranjan, R., J. Irudayaraj, and S. Jun. 2001. Simulation of infrared drying process. Drying Technology. 20(2) 363-379.
137. Ranjan, R., J. Irudayaraj, J. Mahaffy. 2001. Modeling simultaneous heat and mass transfer using the control volume method. Journal of Numerical Heat Transfer. Part B, 41:1-15.
138. Ranjan, R. and J. Irudayaraj, and S. Jun. 2001. Three-dimensional control volume approach to modeling heat and mass transfer in food materials. Transactions of the ASAE. 44(6): 1975-1982
139. Yang, H. and J. Irudayaraj. 2000. Depth profiling Fourier transform analysis of cheese package using generalized two-dimensional photoacoustic correlation spectroscopy. Transactions of the ASAE 43(4):153-961.
140. Sivakesava, S. and J. Irudayaraj. 2000. Determination of sugars in aqueous mixture using mid-infrared spectroscopy. Applied Engineering in Agriculture 16(5):543-550.
141. Yang, H. and J. Irudayaraj. 2000. Depth profiling of a heterogeneous food-packaging model using step-scan Fourier transform infrared photoacoustic spectroscopy. Journal of Food Engineering. 55: 25-33.
142. Cho, Y. and J. Irudayaraj. 2000. Computerization of manufacturing processes and information technology in food industry. Food Science and Industry 33(1):13-19.
143. Sivakesava, S. and J. Irudayaraj. 2000. Quality analysis of potato chips using photoacoustic FTIR spectroscopy. Journal of Food Science. 80(12):1805-1810.
144. Irudayaraj, J. and H. Yang. 2000. Analysis of cheese using step-scan Fourier transform infrared photoacoustic spectroscopy. Applied Spectroscopy 54(4):595-600.
145. Yang, H. and J. Irudayaraj. 1999. Characterization of semi-solid fats and edible oils using Fourier transform infrared photoacoustic spectroscopy. Journal of American Oil Chem. Soc. 77(3):292-295.
146. Yang, H. and J. Irudayaraj. 1999. Estimation of particle size by FTIR DRIFT and PAS. Particulate Science and Technology an International Journal 17(4): 269-282.
147. Bargale, P.C., D. Wulfsohn, J. Irudayaraj, R. J. Ford, and F. W. Sosulski, 1999. Modelling Oil Expression by Uniaxial Compression with Time-Varying Oilseed Properties. Journal of Agricultural Engineering Research 77(2):171-181.
148. Irudayaraj, J. and Wu, Y. 1999. Numerical modeling of heat and mass transfer in starch systems. Transactions of the ASAE. Vol 42(2):449-455.
149. Irudayaraj, J., M. Chen, and D. McMahon. 1999. Study of texture in cheddar cheese using Fourier transform spectroscopy. Canadian Agricultural Engineering Journal. 14(4): 253-258.
150. Bargale, P.C., R.J. Ford, D. Wulfsohn, J. Irudayaraj, and F.W. Sosulski. 1999. Measurement of consolidation and permeability properties of extruded soy under mechanical pressing. Journal of Agricultural Engineering Research 74(2): 155-166.
151. Bargale, P.C, Ford, R.J., Sosulski, F.W., Wulfsohn, D., and Irudayaraj, J. 1999. Mechanical oil expression from extruded soybean samples. J. American Oil Chemists Society, 76 (2):223-229.
152. Chen, M. and J. Irudayaraj. 1998. A sampling technique for the analysis of cheese using FT-IR spectroscopy. Journal of Food Science. (63)1:96-99.
153. Chen, M., J. Irudayaraj, and D. McMahon. 1998. Examination of full-fat and reduced-fat cheddar cheese during ripening using FTIR spectroscopy. J. Dairy Science. 81:2791-2797.
154. Irudayaraj, J. and Wu, Y. 1998. Determination of heat and mass transfer properties in starch based systems. Journal of Food Science 64(2):323-327.
155. Ghazanfari, A., Wulfsohn, D., Irudayaraj, J. 1998. Machine vision grading of Pistachio nuts using gray-level histograms. Canadian Journal of Agricultural Engineering. (40)1:61-66.
156. Ghazanfari, A., Irudayaraj, J. 1997. A Fourier descriptor approach for grading Pistachio nuts. Journal of Agricultural Engineering Research. (68): 247-252.
157. Ghazanfari, A., Kusalik. T, and Irudayaraj, J. 1997. A multi-structure neural network approach for classification. International Journal of Neural Systems. (1):55-61.
158. Irudayaraj, J., and Wu, Y. 1996. Analysis and application of Luikov's heat, mass, and pressure transfer model to a capillary porous media. Drying Technology. Vol 14(3&4):803-824.
159. Wu, Y. and Irudayaraj, J. 1996. Application of simultaneous heat, mass, and pressure equations to timber drying. Numerical Heat Transfer, Part A: Applns. 30(3):233-247.
160. Ghazanfari, A., Irudayaraj, J., and Kusalik, T. 1996. Grading pistachio nuts using a neural network approach. Transactions of the ASAE. 39(6):2319-2324.
161. Ghazanfari, A., and Irudayaraj, J. 1996. Two-dimensional image classification using string matching. Transactions of the ASAE. 39 (3):1197-1202.
162. Wu, Y., and J. Irudayaraj. 1996. Heat, mass and pressure transfer studies in starch based food system. Journal of Food Process Engineering. 29:399-414.
163. Irudayaraj, J., and Wu, Y. 1995. Effect of pressure on moisture transfer during moisture adsorption in barley during steeping. Drying Technology. 13(1&2):1603-1617.
164. Liu, Q., and Irudayaraj, J. 1995. Finite element solution of a moving boundary value problem. Drying Technology. 13(1&2):99-123.
165. Bargale, P.C., and Irudayaraj, J. 1995. Mechanical strength and rheological properties of barley. International Journal of Food Science and Technology. (30)5:609-623.
166. Bargale, P.C., Irudayaraj, J., and Marquis, B. 1995. Studies on rheological behaviour of wheat and canola. Journal of Agricultural Engineering Research. (61) : 267-274.
167. Irudayaraj, J., and Wu, Y. 1994. Finite element analysis of coupled heat, mass, and pressure transfer in porous materials. International Journal of Numerical Heat Transfer. 26(3):337-350.
168. Bargale, P.C., Irudayaraj, J., and Marquis, B. 1994. Some mechanical properties and stress relaxation characteristics of lentils. Canadian Journal of Agricultural Engin. 36(4):247-254.
169. Irudayaraj, J., and Haghighi, K. 1993. Stress analysis of viscoelastic materials during drying: I - Theory and finite element formulation. Drying Tech.: An Intl. Journal. 11(5):901-927.
170. Irudayaraj, J., Haghighi, K. and Stroshine, R.L. 1993. Stress analysis of viscoelastic materials during drying: II - Application to grain kernels. Drying Technology. 11(5):929-959.
171. Fasina, O., and Irudayaraj, J. and Sokhansanj, S. 1993. Three dimensional finite element analysis of moisture sorption process in expanding alfalfa cubes. Journal of Agricultural Engineering Research. (56):337-352.
172. Irudayaraj, J., Haghighi, K. and Stroshine, R.L. 1992. Finite element analysis of drying with application to cereal grains. Journal of Agric. Engineering Research. (53):1-21.
173. Irudayaraj, J., Haghighi, K. and Stroshine, R.L. 1990. Non linear finite element analysis of coupled heat and mass transfer problems. Drying Technology. 8 (4):731-749.
174. Haghighi, K., Irudayaraj, J., Stroshine, R.L. and Sokhansanj, S. 1990. Grain kernel drying simulation using the finite element method. Transactions of the ASAE 33(6):1957-1965.
175. Wu, I-P. and J. Irudayaraj. 1989. Sample size determination for evaluating drip irrigation systems. Transactions of ASAE 32(6):1961-1965.

Books and Chapters
Books

1. Irudayaraj, J. 2011. Biomedical Nanosensors. Taylor and Francis Publishers. (12 Chapters) (in production) (In Press, in Production – Scheduled for Publication in June 2012).
2. Kouassi, G. and Irudayaraj, J. 2011. Magnetic Nanostructures: Basics to Applications. Pan Stanford Publishing. (10 Chapters). (In Progress – Scheduled for completion in Fall 2012).
3. Irudayaraj, J. and Christoph, R. 2008. Nondestructive sensing for food quality. IFT Press, Blackwell Publishing Professional, Ames, IA 50014. (~365 pages).
4. Jun S. and Irudayaraj, J. (Editors) 2008. Food Processing Operations Modeling II (2nd Edition). Marcel Dekker Inc., NY (~375 pages).
5. Irudayaraj, J. (Editor) 2001. Food Processing Operations Modeling I. Marcel Dekker Inc., NY.

Selected Chapters in books. (since 2005)

1. Kouassi, G., Yu, C., Lan, S. and Irudayaraj, J. 2011. Synthesis and preparation of magnetic and gold-coated magnetic nanoparticles. (Chap 2). Part 1. Fabrication and synthesis of inorganic particles. Nanoparticles in Biology and Medicine: Methods and Applications. Humana Press (Springer Science), USA.
2. Kouassi, G., Yu, C., Lan, S. and Irudayaraj, J. 2011. Functionalization and biological and medical applications of magnetic and gold-coated magnetic nanoparticles (Chap 3). Part 1. Fabrication and synthesis of inorganic particles. Nanoparticles in Biology and Medicine: Methods and Applications. Humana Press (Springer Science), USA.
3. Kizil, R. and Irudayaraj, J. 2011. FTIR photoacoustic spectroscopy. Vibrational Spectroscopy Section. Encyclopedia of biophysics. Springer Verlag. (5 pages).
4. Jalilian, R., Jauregui, L., Lee, K, Chen, Y., and Irudayaraj, J. 2010. Graphene for biosensing applications in Biomedical Nanosensors (Ed. Irudayaraj). (20 pages).
5. Yu, C. and Irudayaraj, J. 2007. Sensitivity and selectivity limits of multiplex nanoSPR biosensor assays. Ed. Nagarajan in Nanoparticles: Synthesis, passivation, Stabilization, and Functionalization. ACS Books. American Chemical Society.
6. Subramanian, A., and Irudayaraj, J. 2005. Biosensors for pathogen detection in food. Encyclopedia of Agriculture, Food, and Biological Engin. Taylor and Francis Group. NY.
7. Ranjan, R., Irudayaraj, J., and Reddy, J.N. 2004. Coupled and Non-linear problems: for the Encyclopedia of Agriculture, Food, and Biological Engin. Marcel Dekker Inc. NY (8 pages)
8. Ranjan, R. and Irudayaraj, J. 2003. Unsteady state mass transfer in biological systems. Encyclopedia of Agriculture food and biological engineering. ISSN: 0-8247-0938-1., Marcel Dekker Inc. NY. (7 pages).
9. Sandeep, K. and Irudayaraj, J. 2001. Introduction to modeling and numerical simulation in Food Processing Operations Modeling (Ed. Irudayaraj). Chap 2, pp. 25-37. Marcel Dekker, Inc., NY.
10. Irudayaraj, J. 2000. Transient Mass Transfer in Biological Materials: Mass Transfer in Biological systems. The Encyclopedia of Agricultural and Food Engineering (Ed. Heldman). Marcel Dekker, Inc. New York, NY.
11. Irudayaraj, J. and Y. Wu. 1996. Modelling heat and mass transfer in coupled systems during absorption and desorption. In Mathematical Modelling and Numerical Techniques in Drying Tech. Eds. I. Turner and A. Mujumdar. Chapter 7, pages 279-308. Marcel Dekker, Inc. NY.
12. Irudayaraj, J. 1996. Material non-linearities in finite element analysis. In Selected Topics in Numerical Analysis - A Tutorial Set," Volume 1. Finite element and numerical analysis committee of ASAE. Eds. Mohtar, R., Puri, V., and Carroll, N. ASAE, St. Joseph, MI. pp. 150.

Conferences and Presentations

Invited workshops/symposium presentations

1. Irudayaraj, J. Single molecule-based epigenetic analysis. Second International Symposium on Breast Cancer Prevention, Rennes, France. Oct 9-11 (2011).
2. Irudayaraj, J. Single molecule and single particle technologies for live cell monitoring. High Impact Research to Society at PU and KIST. 6th annual KIST/PU symposium Sept 6th (2011).
3. Irudayaraj, J. Nanosensors and spectroscopy in biosecurity. Univ. Sassari, Italy. 23rd June (2011).
4. Irudayaraj, J. Multifunctional nanomaterials as sensors for targeting and delivery. Material Science and Nanotechnology, Porto Conte Science Park, Sardegna, Italy. 27th June (2011).
5. Irudayaraj, J. Single molecule tools in epigenetics. IUPUI-PCCR retreat, March 26 (2011).
6. Irudayaraj, J. Raman spectroscopy for in vivo detection. Pittcon, Atlanta March 14-17 (2011).
7. Irudayaraj, J. Single molecule spectroscopy in biology. Center for Cellular and Molecular Biology. Hyderabad, India. Jan 4 (2011).
8. Irudayaraj, J. Raman spectroscopy for in vivo detection. Pittcon. Atlanta, GA. March 16 (2011).
9. Irudayaraj, J. Raman chemical mapping of chromate reduction sites. NIH-NIEHS RO1 grantees symposium. Portland, OR. Nov 4-6 (2010).
10. . Irudayaraj, J. Nanosensors for separation and detection of pathogens. Institute of Food Technologists. Chicago, IL. July 17-20 (2010).
11. Irudayaraj, J. Multifunctional gold nanosensors for targeting and delivery. Cancer Nanotech. Symposium, Nano Science and Technology Inst., Anaheim, CA., June 20-24 (2010).
12. Irudayaraj J. Intracellular Raman Imaging. Nanotechnology Conference, University of Illinois at Urbana Champaign. May 12th (2010).
13. Irudayaraj, J. Role of Nanotechnology in Theragnostics. M.G.R. Medical College and University, India. Jan 5th (2010).
14. Irudayaraj, J. Drug delivery and diffusion. Perfint Inc. Chennai, India. Jan 5th (2010).
15. Irudayaraj, J. Nanocharacterization. Tamil Nadu Agricultural University, Dec 29th (2009).
16. Irudayaraj, J. and Chen J. Compartmentalized dynamics and single particle tracking in live cells. SPIE conference, Biophotonics session. San Diego. Aug 2-5. (2009)
17. Irudayaraj, J. Multiplex detection of pathogens by SERS and plasmonics. American Chemical Society. DC. August 16 – 20. (2009)
18. Irudayaraj, J. Raman spectroscopy in Biology. June 5. Chinese Academy of Sciences, Changchun. China. (2009)
19. Irudayaraj, J. Nanotechnology in Cancer research. June 5. North East Normal University, Changchun. China. (2009)
20. Irudayaraj, J. Single molecule methods in biology. Department of Chemical Biology. June 2nd. Beijing University, Beijing, China. (2009)
21. Irudayaraj Joseph. Distinguished Speaker seminar series to the IEEE Electron Device Society- Dallas Section, and the University of Texas at Arlington, NanoFabrication Center. Nanotools for monitoring single cell events. April 28th (2009)
22. Irudayaraj, J. Micro/Nano technology Seminar Series in the Department of Mechanical Engineering in University of Louisville, Feb 27th. “Nanotools in Medicine” (2009)
23. Irudayaraj, J. Single molecule methods for single cell stoichiometry of Toll Like 9 receptor Invited Conference: Fluorescence 2009 in Tata Institute of Fundamental Research. March 15 – 22, (2009).
24. Irudayaraj, J. and Schulz, B. Genomic detection methods, DOW Agro Sciences. Feb 17th (2009) Irudayaraj, J. IUPUI Special Lecture Series. Single Molecule methods in Biology” Feb 16th (2009)
25. Irudayaraj, J. Special Lecture on Multifunctional nanoparticles for tumor targeting. Center for Cellular and Molecular Biology, Hyderabad, India. Jan 6th (2009).
26. Irudayaraj, J. Nanoscale arrays for multiplex DNA sensing. Center for Food Safety Engineering-USDA-ARS workshop, Ocean City, NJ. Oct 12-13 (2008).
27. Rajarajan, M., T. Dar, C. Themistos, A. Rahman, K. Grattan, and J. Irudayaraj. Design and Optimization of Surface Plasmon Resonance Based Biosensor for the Detection of E. coli. 2008 Integrated Photonics and Nanophotonics Research and Applications (IPNRA) Topical Meeting, Boston, MA. July 13-16 (2008).
28. Irudayaraj, J. Nanoscale structures for single cell characterization. 4th International Nanoscience and Nanotechnology Conference. NanoTr4 conference. Istanbul Technical University, Maslak Campus, Istanbul, Turkey. June 9-13, (2008)
29. Irudayaraj, J., A. Wei. Detection and theragonostic applications of gold nanorods. Nanomedicine Center presentation. Korean Institute for Science and Technology. Seoul, S. Korea. June 2-4, (2008).
30. Irudayaraj, J. Nanotechnology in Agriculture. Tamil Nadu Agricultural University. Coimbatore, India. March 24th (2008)
31. Irudayaraj, J. Single cell methodologies. BioNano Conference, Center for Cellular and Molecular Biology, Hyderabad, India. March 13-14, (2008)
32. Irudayaraj, J. Molecular diagnostic tools for cancer. Invited speaker at the Beijing conference and exhibition on instrumental analysis in Beijing, China. Oct 18-20, (2007).
33. Irudayaraj, J. Biosensors in Medicine. Dept of Chemistry, co-hosted by Peiking University and Beijing Institute of Technology (Oct 21, 2007).
34. Irudayaraj, J. Nanobiosenosrs for food safety and quality. Dept of Food Science and nutrition. Ohio State University, Columbus, OH (Nov 27, 2007).
35. Irudayaraj, J. Nanosensors for food packaging. IFT Food Packaging summit, Baltimore, MD (May 7-9, 2006).
36. Irudayaraj, J. Biosensors for medical diagnostics. Indian Institute of Science, Bangalore, India (Dec 27, 2006).
37. Irudayaraj, J. Single molecule biophysics. Dept. of Physics, Barathiar University, Coimbatore, India. (Dec 29, 2006)
38. Irudayaraj, J. Single molecule methods for biomolecule interaction studies. Tata Institute of Fundamental Research, Bombay, India (Dec 15, 2006).
39. Irudayaraj, J. Bionanotechnology curriculum development for agricultural and food scientists. International Food nanotechnology Conference. Orlando, Florida. (June 28-29, 2006).
40. Irudayaraj, J. Bionanotechnology progress, Applied Physics and Engineering, Cornell University (Aug 4, 2005).
41. Vaseashta, A. and J. Irudayaraj. Optical sensors for detection of pathogens and hazardous chemical agents. NATO advanced study institute. Nanostructured and advanced materials for optoelectronic, photovoltaic and sensor applications. Sozopol, Bulgaria (Sept 6-17, 2005).
42. Irudayaraj, J. and G. McCarty. Nanotechnology – Education and Implication. Spring meeting and round table. University-Industry Consortium presentation at Harrisburg, PA. (April 27-28, 2004).
43. Irudayaraj, J. Nanotechnology education for the future workforce. Nanoscale science, engineering, and tech. for food safety and quality. Paper no. 45-2. IFT. Las Vegas. (July 12-16, 2004).
44. Irudayaraj, J. Biosensors: New solutions for the food industry. Non-destructive food testing: Present and Future. Paper no. 21090. IFT. Las Vegas. (July 12-16, 2004).
45. Irudayaraj, J., Yu, C., Gupta M.J. and Subramaniam, A. 2004. Optical Sensors for Food Pathogen and Hazardous Chemical Agent Detection for ISS and Planetary Outpost. July 19-22, Colorado Springs, CO. pp. 20-24.
46. Irudayaraj, J. Drying of pharmaceuticals and biomaterials. Invited lecture at the International Workshop and symposium on Industrial Drying, Mumbai, India. (Dec 20-23, 2004).
47. Irudayaraj, J. 2003. Review of Sensor methodologies for food quality and safety. Presentation at the Electrical Engineering Seminar series, Penn State (Nov 11, 2003).
48. Irudayaraj, J. 2002. Perspectives of teaching and research in Agricultural and Biological Engineering. College of Agricultural Engineering, Tamil Nadu Agricultural University, Coimbatore, India. (Dec 23-24).
49. Irudayaraj, J. 2002. Food Quality and Safety assessment for agricultural produce. Value added products: Opportunities for agro industrial units. Gujarat Agricultural University, Junagadh. Gujarat, India. (Dec 16-17).
50. Irudayaraj, J. 2002. Food quality sensors. Departamento de Tecnología de Alimentos, Universidad Politechnica de Valencia, Valencia, Spain. July 9th.
51. Irudayaraj, J. 2002. Depth profile characterization and quality attribute sensing of food materials. First Annual Materials Day, Penn State (April 15, 2000).
52. Irudayaraj, J. 2001. Spectroscopic measurements for on-line determinations. First International Workshop on Mathematical and Computing Techniques for Agro-Food Technologies, Barcelona, Spain. (Nov 26-27).
53. Yang, H. and J. Irudayaraj, 2000. Characterization of food powders and thin layers using Fourier Transform Infrared Photoacoustic Spectroscopy – Innovations in particulate materials for the new illennium. Particulate Materials Center, MRL (May 23-24).
54. Irudayaraj, J. and H. Yang. 1999. Probing food surfaces. Technologies for the New Millennium. Westin-William Penn, Pittsburgh, PA (November 1-2).
55. Irudayaraj, J. Invited speaker in the session on 25 years of finite elements in Agricultural Engineering at the ASAE 1999 International Meeting. Title of the invited presentation was Heat and mass transfer in food systems. (Participation level: Invited speaker for Part II of the two part lecture), Toronto, Canada. July 18-22, (1999).
56. Irudayaraj, J., P.C. Bargale, and S. Sokhansanj. Trends in postharvest processing. Conference of the 29th Caribbean food crops society. Port-de-France, Martinique. July 3-10, (1993).

Seminar series presentations in Purdue (selected).

1. Irudayaraj, J. Plasmonic biosensors, Biophysics seminar series, Dept. Physics, (Oct 3, 2011).
2. Irudayaraj, J. Nanotechnology in health diagnostics (NSF-REU), Dept. Physics, (July 13, 2011).
3. Irudayaraj, J. Nanomaterials in biology. Bindley Seminar series. (Mar 3, 2011).
4. Irudayaraj, J. Basics of Epigenetics. International Breast Cancer Prevention. (Feb 24, 2011). Irudayaraj,
5. J. Single molecule methods in biology. Bindley Seminar series. (Oct 29, 2010).
6. Irudayaraj, J. 2008. Confocal Raman microscopy for single cell monitoring. Confocal microscopy Seminar, Purdue University (April 23, 2008).
7. Irudayaraj, J. 2008. Nanoscale sensors for detection and targeting. Basic Medical Sciences, Purdue University (April 24, 2008).
8. Irudayaraj, J. 2007. Single molecule methods for cell surface biomarker interaction. Biological Sciences, Cell growth and Differentiation group, Purdue University (Nov 15, 2007).
9. Irudayaraj, J. 2007. Imaging and diagnostic tools for cancer. Purdue Cancer Center Evaluation seminar presentation, Purdue University (Nov 15, 2007).
10. Irudayaraj, J. 2006. IUPUI Invited lecture. Strategies for intra cellular probing. Dept of Biochemistry Seminar Series (Oct 2, 2006).

Contributed conference/symposium presentations and proceedings [“(*)” presented and published in peer-reviewed conference proceedings] listing selected 15 (total presentation over 300)

1. Chen, J. (*)Irudayaraj, J. 2011. Single molecule in vivo analysis of Toll-like receptor 9 and CpG DNA interaction. 55th Biophysical Society meeting. (March 9, Baltimore, MD).
2. (*)Chen J, Irudayaraj J. 2010. Fluorescence lifetime correlation spectroscopy resolves EGFR interaction in live cells. SPIE proceedings. SPIE Photonics West, Single molecule spectroscopy and Imaging II. (Jan 23, San Francisco, CA).
3. Wereley, S., Kumar, A., Kwon, J., Ravindranath, S., and Irudayaraj, J. 2010. Application of an optically induced electrokinetic manipulation technique on live bacteria. IMECE conference. Paper #. IMECE2010-39324. Best Paper Award, ASME-IMECE Microfluidics 2010.
4. (*)Nag, S., Sahoo, B., Chen, J., Muralidharan, C., Shah, R., Joseph Irudayaraj, J., and Maiti. S. 2009. Investigating Amyloid Aggregates At Different Size Scales. Biophysical Society: 451-Pos Board B330 1. [Feb 1, 2009] 96 (3), 87a.
5. Kizil, R. and J. Irudayaraj, 2008. Characterization and Classification of Gamma-Irradiated
   Adipose Tissues Using Raman Spectroscopy and Chemometrics AIChE abstract. 2008 Annual Meeting (Food, Pharmaceutical, and Bioengineering Division), Philadelphia, PA. (Nov 16-21).
6. Rajarajan, M., T. Dar, C. Themistos, A. Rahman, K. Grattan, and J. Irudayaraj, 2008. Design and Optimization of Surface Plasmon Resonance Based Biosensor for the Detection of E. coli. 2008 Integrated Photonics and Nanophotonics Research and Applications (IPNRA) Topical Meeting, Boston, MA (July 13-16).
7. Yu, C. and J. Irudayaraj, 2007. Sensitivity and selectivity of multiplex nanoSPR biosensor assays. Nanoparticles: Synthesis, Passivation, Stabilization, and Functionalization. [Coll 575] The 233rd ACS National Meeting, Chicago, IL (March 25-29).
8. Yu, C. and J. Irudayaraj, 2007. Identification of metastatic subpopulations of breast cancer progenitor cells using gold nanorod probes. [Coll 533] The 233rd ACS National Meeting, Chicago, IL (March 25-29).
9. Lan, S. and J. Irudayaraj. 2007. Poster: Multiplex sensing using Confocal Raman” First place (out of 24 posters) in Life Sciences category (Feb 28).
10. Yu, C. and J. Irudayaraj. 2007. “Single Cell identity profiling”. Poster: Cancer Prevention Poster Competition. Oncological Sciences Center. Third Place (May 27).
11. Strychalski, E., J. Irudayaraj, and H. Craighead, 2005. Poster: Deep-microfluidic devices in glass and plastic for sorting and recovery of mammalian and microbial cells. Nanobiotechnology Center Conference, Cornell University (Aug 15-16).
12. Santhanam, N., J. Irudayaraj, J. Edel, H. Craighead, and L. Walker, 2005. Poster: Study of the surface mobility of cellulases on cellulose nanofibrils using Fluorescence Correlation Spectroscopy. Nanobiotechnology Conference, Cornell University, Ithaca, NY (August 15-16).
13. Chanda, R., Irudayaraj, J., Pantano, C. 2004. Characterization of thin films for optical sensors of food-borne pathogens. Proceedings of the SPIE - The international Society for Optical Engineering (SPIE), Boston, MA., Oct 25-28, 5591 (Lab-on-1-Chip: Platforms, devices, and Applications, Eds. Smith and Sobek): 231-238. Boston, MA.
14. (*)Cho, B. and Irudayaraj, J. 2003. Non-contact ultrasound imaging for foreign object detection in cheese and poultry in Emerging technologies in NDT. [Eds. D. Hemelrijck, A. Anastasopoulos, and N. Melanitis]. The Netherlands. Proceedings of the 3rd international conference on emerging technologies in non-destructive testing, May 26-28. Thessaloniki, Greece. pp. 351-354.
15. Waswa, J., J. Irudayaraj, C. DebRoy, and A. Demirci, 2002. Poster: Surface plasmon resonance based biosensor assays for detection of Escherichia coli O157:H7 in food samples. 16th of November, 2002 at Clarion University. Presented at the Allegheny Branch of the American Society for Microbiology (ABASM) [Student poster contest, 1st Prize]

CONFERENCES AND PRESENTATIONS

Invited workshops/symposium presentations (since 2005)

1. Irudayaraj, J. Single molecule-based epigenetic analysis. Second International Symposium on Breast Cancer Prevention, Rennes, France. Oct 9-11 (2011).
2. Irudayaraj, J. Single molecule and single particle technologies for live cell monitoring. High Impact Research to Society at PU and KIST. 6th annual KIST/PU symposium Sept 6th (2011).
3. Irudayaraj, J. Nanosensors and spectroscopy in biosecurity. University of Sassari, Italy. 23rd June (2011).
4. Irudayaraj, J. Multifunctional nanomaterials as sensors for targeting and delivery. Material Science and Nanotechnology, Porto Conte Science Park, Sardegna, Italy. 27th June (2011).
5. Irudayaraj, J. Single molecule tools in epigenetics. IUPUI-PCCR retreat, March 26 (2011).
6. Irudayaraj, J. Raman spectroscopy for in vivo detection. Pittcon, Atlanta March 14-17 (2011).
7. Irudayaraj, J. Single molecule spectroscopy in biology. Center for Cellular and Molecular Biology. Hyderabad, India. Jan 4 (2011).
8. Irudayaraj, J. Raman spectroscopy for in vivo detection. Pittcon. Atlanta, GA. March 16 (2011).
9. Irudayaraj, J. Raman chemical mapping of chromate reduction sites. NIH-NIEHS RO1 grantees symposium. Portland, OR. Nov 4-6 (2010).
10. Irudayaraj, J. Nanosensors for separation and detection of pathogens. Institute of Food Technologists. Chicago, IL. July 17-20 (2010).
11. Irudayaraj, J. Multifunctional gold nanosensors for targeting and delivery. Cancer Nanotech. Symposium, Nano Science and Technology Inst., Anaheim, CA., June 20-24 (2010).
12. Irudayaraj J. Intracellular Raman Imaging. Nanotechnology Conference, University of Illinois at Urbana Champaign. May 12th (2010).
13. Irudayaraj, J. Role of Nanotechnology in Theragnostics. M.G.R. Medical College and University, India. Jan 5th (2010).
14. Irudayaraj, J. Drug delivery and diffusion. Perfint Inc. Chennai, India. Jan 5th (2010).
15. Irudayaraj, J. Nanocharacterization. Tamil Nadu Agricultural University, Dec 29th (2009).
16. Irudayaraj, J. and Chen J. Compartmentalized dynamics and single particle tracking in live cells. SPIE conference, Biophotonics session. San Diego. Aug 2-5. (2009)
17. Irudayaraj, J. Multiplex detection of pathogens by SERS and plasmonics. American Chemical Society. DC. August 16 – 20. (2009)
18. Irudayaraj, J. Raman spectroscopy in Biology. June 5. Chinese Academy of Sciences, Changchun. China. (2009)
19. Irudayaraj, J. Nanotechnology in Cancer research. June 5. North East Normal University, Changchun. China. (2009)
20. Irudayaraj, J. Single molecule methods in biology. Department of Chemical Biology. June 2nd. Beijing University, Beijing, China. (2009)
21. Irudayaraj Joseph. Distinguished Speaker seminar series to the IEEE Electron Device Society- Dallas Section, and the University of Texas at Arlington, NanoFabrication Center. Nanotools for monitoring single cell events. April 28th (2009)
22. Irudayaraj, J. Micro/Nano technology Seminar Series in the Department of Mechanical Engineering in University of Louisville, Feb 27th. “Nanotools in Medicine” (2009)
23. Irudayaraj, J. Single molecule methods for single cell stoichiometry of Toll Like 9 receptor Invited Conference: Fluorescence 2009 in Tata Institute of Fundamental Research. March 15 – 22, (2009).
24. Irudayaraj, J. and Schulz, B. Genomic detection methods, DOW Agro Sciences. Feb 17th (2009)
    Irudayaraj, J. IUPUI Special Lecture Series. Single Molecule methods in Biology” Feb 16th (2009)
25. Irudayaraj, J. Special Lecture on Multifunctional nanoparticles for tumor targeting. Center for Cellular and Molecular Biology, Hyderabad, India. Jan 6th (2009).
26. Irudayaraj, J. Nanoscale arrays for multiplex DNA sensing. Center for Food Safety Engineering-USDA-ARS workshop, Ocean City, NJ. Oct 12-13 (2008).
27. Rajarajan, M., T. Dar, C. Themistos, A. Rahman, K. Grattan, and J. Irudayaraj. Design and Optimization of Surface Plasmon Resonance Based Biosensor for the Detection of E. coli. 2008 Integrated Photonics and Nanophotonics Research and Applications (IPNRA) Topical Meeting, Boston, MA. July 13-16 (2008).
28. Irudayaraj, J. Nanoscale structures for single cell characterization. 4th International Nanoscience and Nanotechnology Conference. NanoTr4 conference. Istanbul Technical University, Maslak Campus, Istanbul, Turkey. June 9-13, (2008)
29. Irudayaraj, J., A. Wei. Detection and theragonostic applications of gold nanorods. Nanomedicine Center presentation. Korean Institute for Science and Technology. Seoul, S. Korea. June 2-4, (2008).
30. Irudayaraj, J. Nanotechnology in Agriculture. Tamil Nadu Agricultural University. Coimbatore, India. March 24th (2008)
31. Irudayaraj, J. Single cell methodologies. BioNano Conference, Center for Cellular and Molecular Biology, Hyderabad, India. March 13-14, (2008)
32. Irudayaraj, J. Molecular diagnostic tools for cancer. Invited speaker at the Beijing conference and exhibition on instrumental analysis in Beijing, China. Oct 18-20, (2007).
33. Irudayaraj, J. Biosensors in Medicine. Dept of Chemistry, co-hosted by Peiking University and Beijing Institute of Technology (Oct 21, 2007).
34. Irudayaraj, J. Nanobiosenosrs for food safety and quality. Dept of Food Science and nutrition. Ohio State University, Columbus, OH (Nov 27, 2007).
35. Irudayaraj, J. Nanosensors for food packaging. IFT Food Packaging summit, Baltimore, MD (May 7-9, 2006).
36. Irudayaraj, J. Biosensors for medical diagnostics. Indian Institute of Science, Bangalore, India (Dec 27, 2006).
37. Irudayaraj, J. Single molecule biophysics. Dept. of Physics, Barathiar University, Coimbatore, India. (Dec 29, 2006)
38. Irudayaraj, J. Single molecule methods for biomolecule interaction studies. Tata Institute of Fundamental Research, Bombay, India (Dec 15, 2006).
39. Irudayaraj, J. Bionanotechnology curriculum development for agricultural and food scientists. International Food nanotechnology Conference. Orlando, Florida. (June 28-29, 2006).
40. Irudayaraj, J. Bionanotechnology progress, Applied Physics and Engineering, Cornell University (Aug 4, 2005).
41. Vaseashta, A. and J. Irudayaraj. Optical sensors for detection of pathogens and hazardous chemical agents. NATO advanced study institute. Nanostructured and advanced materials for optoelectronic, photovoltaic and sensor applications. Sozopol, Bulgaria (Sept 6-17, 2005).
42. Irudayaraj, J. and G. McCarty. Nanotechnology – Education and Implication. Spring meeting and round table. University-Industry Consortium presentation at Harrisburg, PA. (April 27-28, 2004).
43. Irudayaraj, J. Nanotechnology education for the future workforce. Nanoscale science, engineering, and tech. for food safety and quality. Paper no. 45-2. IFT. Las Vegas. (July 12-16, 2004).
44. Irudayaraj, J. Biosensors: New solutions for the food industry. Non-destructive food testing: Present and Future. Paper no. 21090. IFT. Las Vegas. (July 12-16, 2004).
45. Irudayaraj, J., Yu, C., Gupta M.J. and Subramaniam, A. 2004. Optical Sensors for Food Pathogen and Hazardous Chemical Agent Detection for ISS and Planetary Outpost. July 19-22, Colorado Springs, CO. pp. 20-24.
46. Irudayaraj, J. Drying of pharmaceuticals and biomaterials. Invited lecture at the International Workshop and symposium on Industrial Drying, Mumbai, India. (Dec 20-23, 2004).
47. Irudayaraj, J. 2003. Review of Sensor methodologies for food quality and safety. Presentation at the Electrical Engineering Seminar series, Penn State (Nov 11, 2003).
48. Irudayaraj, J. 2002. Perspectives of teaching and research in Agricultural and Biological Engineering. College of Agricultural Engineering, Tamil Nadu Agricultural University, Coimbatore, India. (Dec 23-24).
49. Irudayaraj, J. 2002. Food Quality and Safety assessment for agricultural produce. Value added products: Opportunities for agro industrial units. Gujarat Agricultural University, Junagadh. Gujarat, India. (Dec 16-17).
50. Irudayaraj, J. 2002. Food quality sensors. Departamento de Tecnología de Alimentos, Universidad Politechnica de Valencia, Valencia, Spain. July 9th.

Seminar series presentations in Purdue (selected).

1. Irudayaraj, J. Plasmonic biosensors, Biophysics seminar series, Dept. Physics, (Oct 3, 2011).
2. Irudayaraj, J. Nanotechnology in health diagnostics (NSF-REU), Dept. Physics, (July 13, 2011).
3. Irudayaraj, J. Nanomaterials in biology. Bindley Seminar series. (Mar 3, 2011).
4. Irudayaraj, J. Basics of Epigenetics. International Breast Cancer Prevention. (Feb 24, 2011).
   Joseph MK Irudayaraj Page 30
5. Irudayaraj, J. Single molecule methods in biology. Bindley Seminar series. (Oct 29, 2010).
6. Irudayaraj, J. 2008. Confocal Raman microscopy for single cell monitoring. Confocal microscopy Seminar, Purdue University (April 23, 2008).
7. Irudayaraj, J. 2008. Nanoscale sensors for detection and targeting. Basic Medical Sciences, Purdue University (April 24, 2008).
8. Irudayaraj, J. 2007. Single molecule methods for cell surface biomarker interaction. Biological Sciences, Cell growth and Differentiation group, Purdue University (Nov 15, 2007).
9. Irudayaraj, J. 2007. Imaging and diagnostic tools for cancer. Purdue Cancer Center Evaluation seminar presentation, Purdue University (Nov 15, 2007).
10. Irudayaraj, J. 2006. IUPUI Invited lecture. Strategies for intra cellular probing. Dept of Biochemistry Seminar Series (Oct 2, 2006).

Contributed conference/symposium presentations and proceedings [“(*)” presented and published in peer-reviewed conference proceedings] listing selected 15 (total presentation over 300)

1. hen, J. (*)Irudayaraj, J. 2011. Single molecule in vivo analysis of Toll-like receptor 9 and CpG DNA interaction. 55th Biophysical Society meeting. (March 9, Baltimore, MD).
2. (*)Chen J, Irudayaraj J. 2010. Fluorescence lifetime correlation spectroscopy resolves EGFR interaction in live cells. SPIE proceedings. SPIE Photonics West, Single molecule spectroscopy and Imaging II. (Jan 23, San Francisco, CA).
3. Wereley, S., Kumar, A., Kwon, J., Ravindranath, S., and Irudayaraj, J. 2010. Application of an optically induced electrokinetic manipulation technique on live bacteria. IMECE conference. Paper #. IMECE2010-39324. Best Paper Award, ASME-IMECE Microfluidics 2010.
4. (*)Nag, S., Sahoo, B., Chen, J., Muralidharan, C., Shah, R., Joseph Irudayaraj, J., and Maiti. S. 2009. Investigating Amyloid Aggregates At Different Size Scales. Biophysical Society: 451-Pos Board B330 1. [Feb 1, 2009] 96 (3), 87a.
5. Kizil, R. and J. Irudayaraj, 2008. Characterization and Classification of Gamma-Irradiated
   Adipose Tissues Using Raman Spectroscopy and Chemometrics AIChE abstract. 2008 Annual Meeting (Food, Pharmaceutical, and Bioengineering Division), Philadelphia, PA. (Nov 16-21).
6. Rajarajan, M., T. Dar, C. Themistos, A. Rahman, K. Grattan, and J. Irudayaraj, 2008. Design and Optimization of Surface Plasmon Resonance Based Biosensor for the Detection of E. coli. 2008 Integrated Photonics and Nanophotonics Research and Applications (IPNRA) Topical Meeting, Boston, MA (July 13-16).
7. Yu, C. and J. Irudayaraj, 2007. Sensitivity and selectivity of multiplex nanoSPR biosensor assays. Nanoparticles: Synthesis, Passivation, Stabilization, and Functionalization. [Coll 575] The 233rd ACS National Meeting, Chicago, IL (March 25-29).
8. Yu, C. and J. Irudayaraj, 2007. Identification of metastatic subpopulations of breast cancer progenitor cells using gold nanorod probes. [Coll 533] The 233rd ACS National Meeting, Chicago, IL (March 25-29).
9. Lan, S. and J. Irudayaraj. 2007. Poster: Multiplex sensing using Confocal Raman” First place (out of 24 posters) in Life Sciences category (Feb 28).
10. . Yu, C. and J. Irudayaraj. 2007. “Single Cell identity profiling”. Poster: Cancer Prevention Poster Competition. Oncological Sciences Center. Third Place (May 27).
11. Strychalski, E., J. Irudayaraj, and H. Craighead, 2005. Poster: Deep-microfluidic devices in glass and plastic for sorting and recovery of mammalian and microbial cells. Nanobiotechnology Center Conference, Cornell University (Aug 15-16).
12. Santhanam, N., J. Irudayaraj, J. Edel, H. Craighead, and L. Walker, 2005. Poster: Study of the surface mobility of cellulases on cellulose nanofibrils using Fluorescence Correlation Spectroscopy. Nanobiotechnology Conference, Cornell University, Ithaca, NY (August 15-16).
13. Chanda, R., Irudayaraj, J., Pantano, C. 2004. Characterization of thin films for optical sensors of food-borne pathogens. Proceedings of the SPIE - The international Society for Optical Engineering (SPIE), Boston, MA., Oct 25-28, 5591 (Lab-on-1-Chip: Platforms, devices, and Applications, Eds. Smith and Sobek): 231-238. Boston, MA.
14. (*)Cho, B. and Irudayaraj, J. 2003. Non-contact ultrasound imaging for foreign object detection in cheese and poultry in Emerging technologies in NDT. [Eds. D. Hemelrijck, A. Anastasopoulos, and N. Melanitis]. The Netherlands. Proceedings of the 3rd international conference on emerging technologies in non-destructive testing, May 26-28. Thessaloniki, Greece. pp. 351-354.
15. Waswa, J., J. Irudayaraj, C. DebRoy, and A. Demirci, 2002. Poster: Surface plasmon resonance based biosensor assays for detection of Escherichia coli O157:H7 in food samples. 16th of November, 2002 at Clarion University. Presented at the Allegheny Branch of the American Society for Microbiology (ABASM) [Student poster contest, 1st Prize].