Immunology and Inflammation

Dramatic advances in immunology have led to the control of many chronic inflammatory process and have had a paradigm shifting impact on immunotherapy of cancer. Basic scientific discoveries provided a basis for abrogating cancer promoting aspects of immunity, treating inflammatory diseases, detecting viruses, bacteria, and parasites, and the development of new vaccines and therapeutics. The pursuit of understanding immunology led to unprecedented insight into the normal functioning of cells and tissues. To control diseases, humans have an exquisite system that monitors the body for altered cells (cancer), foreign pathogens and abnormal cellular events including chronic inflammation. The ability to detect the difference between self and non-self is tightly controlled yet there are numerous human diseases associated with the breakdown of this surveillance system, resulting in inflammation and conditions such as arthritis, autoimmune disease and cancer. This program area will continue to produce relevant research and prepare future generations of immunologists through our PULSe training group. 

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