Purdue researchers apply new technique to manipulate virus, make it a possible cancer treatment
November 27, 2013
WEST LAFAYETTE, Ind. — Purdue University researchers successfully eliminated the native infection preferences of a Sindbis virus engineered to target and kill cancer cells, a milestone in the manipulation of this promising viral vector.
"This virus had been known to be a good vector for delivering therapeutic cargo, however it naturally infected all kinds of cells, and these diversions would compete with what we were instructing it to target," said Richard Kuhn, the Gerald and Edna Mann Director of Purdue's Bindley Biosciences Center. "We have now overcome a major challenge by not only inserting a targeting molecule of our choice, but also successfully stripping the virus of its native entry preferences. This was a big step in unlocking the potential of developing this virus into a platform for both targeted drug delivery, where it would sneak drugs inside cancer cells, and oncolytic virotherapy, where the virus itself destroys cancer cells."
- Elizabeth K. Gardner, Writer
October 29, 2014
Purdue University ecologist Bryan Pijanowski gained international attention for an Earth Day effort to capture soundscapes from citizen scientists. Now, he is launching a research center aimed at preserving the sounds of the Earth and highlighting their bellwether role in alerting scientists to environmental habitat changes by species.Read Full Story
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Purdue University forestry and natural resources and biological sciences professor Jeffrey Dukes has been selected as the new director of the Purdue Climate Change Research Center in Discovery Park.Read Full Story
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SPEAK MODalities LLC, a startup commercializing an iPad application to help improve communication for children and families affected by severe, nonverbal autism, received top honors at the 2014 International 2014 GAIN-TEN Business Pitch Challenge.Read Full Story