Purdue researchers apply new technique to manipulate virus, make it a possible cancer treatment
November 27, 2013
WEST LAFAYETTE, Ind. — Purdue University researchers successfully eliminated the native infection preferences of a Sindbis virus engineered to target and kill cancer cells, a milestone in the manipulation of this promising viral vector.
"This virus had been known to be a good vector for delivering therapeutic cargo, however it naturally infected all kinds of cells, and these diversions would compete with what we were instructing it to target," said Richard Kuhn, the Gerald and Edna Mann Director of Purdue's Bindley Biosciences Center. "We have now overcome a major challenge by not only inserting a targeting molecule of our choice, but also successfully stripping the virus of its native entry preferences. This was a big step in unlocking the potential of developing this virus into a platform for both targeted drug delivery, where it would sneak drugs inside cancer cells, and oncolytic virotherapy, where the virus itself destroys cancer cells."
- Elizabeth K. Gardner, Writer
November 19, 2014
United States Secretary of Agriculture Tom Vilsack is on the Purdue University campus learning more about developments in the field of biofuels.Read Full Story
November 18, 2014
President Mitch Daniels and Andrew Schenk, graduate research assistant, discuss research at Purdue's Maha Fluid Power Research Center on Friday (Nov. 14). Daniels was taking a tour of the center, which recently celebrated its 10th anniversary. The center's research activities focus on two major areas: energy-saving hydraulic drive systems and the development and optimization of pumps and motors.Read Full Story
November 18, 2014
Researchers at Purdue University report a proof-of-concept of a their novel consecutive two-step process (H2Bioil) for the production of liquid fuel range hydrocarbons (C4+) with undetectable oxygen content from cellulose and an intact biomass (poplar). (Earlier post.)Read Full Story