Purdue researchers apply new technique to manipulate virus, make it a possible cancer treatment
November 27, 2013
WEST LAFAYETTE, Ind. — Purdue University researchers successfully eliminated the native infection preferences of a Sindbis virus engineered to target and kill cancer cells, a milestone in the manipulation of this promising viral vector.
"This virus had been known to be a good vector for delivering therapeutic cargo, however it naturally infected all kinds of cells, and these diversions would compete with what we were instructing it to target," said Richard Kuhn, the Gerald and Edna Mann Director of Purdue's Bindley Biosciences Center. "We have now overcome a major challenge by not only inserting a targeting molecule of our choice, but also successfully stripping the virus of its native entry preferences. This was a big step in unlocking the potential of developing this virus into a platform for both targeted drug delivery, where it would sneak drugs inside cancer cells, and oncolytic virotherapy, where the virus itself destroys cancer cells."
- Elizabeth K. Gardner, Writer
July 14, 2014
A group of Russian undergraduate students will spend a month of their summer at Purdue University and the Purdue Research Park to expand their knowledge of entrepreneurship and startup company development. Twelve students were selected by a committee of American and Russian specialists in economic policy and entrepreneurship to participate in the Yegor Gaidar Summer Leadership Program, which will run from Monday (July 14) through Aug. 2.Read Full Story
July 11, 2014
Three international conferences this month at Purdue University will focus on innovative concepts for air conditioning, refrigeration and high-performance buildings. More than 700 people are expected to attend the 15th International Refrigeration and Air Conditioning Conference, the 22nd International Compressor Engineering Conference and the third International High Performance Buildings Conference from July 14-17. The conferences are held every two years. Participants will present a record number of research papers - 410 - representing about a 10 percent increase over the previous record.Read Full Story
July 9, 2014
Moments after Dr. Jeff Crecelius completes a surgery, hopeful family members typically want to know if he was able to "get it all," or remove all of the cancerous tumor from the brain of a loved one. It's their emotional plea for reassurance. They want to know that the ordeal is completed and that the brain tumor has met its match — the hands of a skilled surgeon.Read Full Story