Purdue researchers apply new technique to manipulate virus, make it a possible cancer treatment
November 27, 2013
WEST LAFAYETTE, Ind. — Purdue University researchers successfully eliminated the native infection preferences of a Sindbis virus engineered to target and kill cancer cells, a milestone in the manipulation of this promising viral vector.
"This virus had been known to be a good vector for delivering therapeutic cargo, however it naturally infected all kinds of cells, and these diversions would compete with what we were instructing it to target," said Richard Kuhn, the Gerald and Edna Mann Director of Purdue's Bindley Biosciences Center. "We have now overcome a major challenge by not only inserting a targeting molecule of our choice, but also successfully stripping the virus of its native entry preferences. This was a big step in unlocking the potential of developing this virus into a platform for both targeted drug delivery, where it would sneak drugs inside cancer cells, and oncolytic virotherapy, where the virus itself destroys cancer cells."
- Elizabeth K. Gardner, Writer
April 11, 2014
Panel discussions and presentations are planned at a meeting this month for the second phase of the Indiana Clinical and Translational Sciences Institute (CTSI), a partnership between Purdue University, Indiana University and the University of NotreRead Full Story
April 11, 2014
Purdue University Libraries and Press, the College of Liberal Arts, the Global Policy Research Institute, and Discovery Park have received a $539,000 grant from the Andrew W. Mellon Foundation to support collaborations of humanists, social scientistsRead Full Story
April 10, 2014
Dr. Elisa Bertino, Cyber Center Director, presented a paper at the recent IEEE 20th ICDE Conference in Chicago, ILRead Full Story