Purdue researchers apply new technique to manipulate virus, make it a possible cancer treatment
November 27, 2013
WEST LAFAYETTE, Ind. — Purdue University researchers successfully eliminated the native infection preferences of a Sindbis virus engineered to target and kill cancer cells, a milestone in the manipulation of this promising viral vector.
"This virus had been known to be a good vector for delivering therapeutic cargo, however it naturally infected all kinds of cells, and these diversions would compete with what we were instructing it to target," said Richard Kuhn, the Gerald and Edna Mann Director of Purdue's Bindley Biosciences Center. "We have now overcome a major challenge by not only inserting a targeting molecule of our choice, but also successfully stripping the virus of its native entry preferences. This was a big step in unlocking the potential of developing this virus into a platform for both targeted drug delivery, where it would sneak drugs inside cancer cells, and oncolytic virotherapy, where the virus itself destroys cancer cells."
- Elizabeth K. Gardner, Writer
October 22, 2014
Purdue University forestry and natural resources and biological sciences professor Jeffrey Dukes has been selected as the new director of the Purdue Climate Change Research Center in Discovery Park.Read Full Story
October 17, 2014
SPEAK MODalities LLC, a startup commercializing an iPad application to help improve communication for children and families affected by severe, nonverbal autism, received top honors at the 2014 International 2014 GAIN-TEN Business Pitch Challenge.Read Full Story
October 17, 2014
Registration is underway for the 28th annual Burton D. Morgan Business Plan Competition, the third-oldest business plan competition in the country, slated for Feb. 17 at Purdue University's Discovery Park.Read Full Story