Purdue researchers apply new technique to manipulate virus, make it a possible cancer treatment
November 27, 2013
WEST LAFAYETTE, Ind. — Purdue University researchers successfully eliminated the native infection preferences of a Sindbis virus engineered to target and kill cancer cells, a milestone in the manipulation of this promising viral vector.
"This virus had been known to be a good vector for delivering therapeutic cargo, however it naturally infected all kinds of cells, and these diversions would compete with what we were instructing it to target," said Richard Kuhn, the Gerald and Edna Mann Director of Purdue's Bindley Biosciences Center. "We have now overcome a major challenge by not only inserting a targeting molecule of our choice, but also successfully stripping the virus of its native entry preferences. This was a big step in unlocking the potential of developing this virus into a platform for both targeted drug delivery, where it would sneak drugs inside cancer cells, and oncolytic virotherapy, where the virus itself destroys cancer cells."
- Elizabeth K. Gardner, Writer
January 29, 2015
“Close your eyes and imagine you are living 200 years from now. Get up in the morning and you are not allowed to touch fossil fuels,” is the contemplative daydream of Dr. Rakesh Agrawal, distinguished professor of chemical engineering at Purdue University, master inventor and revolutionary thinker who simply cannot help himself, he said, in elevating the discussion of energy solutions and the everyday challenges a solar economy would resolve. Agrawal gave the prestigious fall public lecture for Texas A&M’s Institute for Advanced Study, for which he is a current Faculty Fellow. He addressed the plight of finite energy sources in light of practical, societal needs and the impact of which that has influenced progress and modernization, spanning the history of the human race.Read Full Story
January 26, 2015
Research probing the complex science behind the formation of "dendrites" that cause lithium-ion batteries to fail could bring safer, longer-lasting batteries capable of being charged within minutes instead of hours.Read Full Story
January 20, 2015
Purdue University is part of a deep and diverse team selected by the U.S. Department of Energy to lead a $259 million initiative to develop the next generation of energy-efficient vehicles and wind energy and compressed-gas storage technologies.Read Full Story