Bionanotechnology and Nanomedicine

New pump created for microneedle drug-delivery patch

Researchers have developed a new type of pump for drug-delivery patches that might use arrays of "microneedles" to deliver a wider range of medications than now possible with conventional patches.

Nanoscopic probes can track down and attack cancer cells

A researcher has developed probes that can help pinpoint the location of tumors and might one day be able to directly attack cancer cells.

Nano-tetherball biosensor precisely detects glucose

Researchers have created a precise biosensor for detecting blood glucose and potentially many other biological molecules by using hollow structures called single-wall carbon nanotubes anchored to gold-coated "nanocubes."

'Ferropaper' is new technology for small motors, robots

Researchers at Purdue University have created a magnetic "ferropaper" that might be used to make low-cost "micromotors" for surgical instruments, tiny tweezers to study cells and miniature speakers.

Sensor important to understanding root, seedling development

A biosensor utilizing black platinum and carbon nanotubes developed at Purdue University will help give scientists a better understanding of how the plant hormone auxin regulates root growth and seedling establishment.

About the research

The direct result of interdisciplinary research is the creation of new disciplines. Researchers at the Birck Nanotechnology center are leading on the cutting edge of research that is pioneering the new foundations of nanobiotechnology. At the juncture of the new century fundamental biosciences are providing the framework for technology and engineering at the nanoscale. This has the potential to play a role in solving many of the grand challenges that we face in food security, environmental solvency, and meeting future energy needs. In particular there are significant advances in nanomedicine that will improve the quality of life, as well as to provide an engine for future economic development. Our work in this field includes new nanomaterial therapy technologies for cancer, advanced approaches for nanoscale drug delivery, nanobiosensors for diabetes, and advanced nanodevices for diagnosis and detection of pathogens and disease for personalized medicine. 


Principal Investigators

Alam

Theory, simulation, characterization, and compact modeling of semiconductor electronic, optoelectronic, and bio-electronic devices

Muhammad A. Alam

Theory, simulation, characterization, and compact modeling of semiconductor electronic, optoelectronic, and bio-electronic devices

Donald E. Bergstrom

Design and synthesis of modified nucleosides and nucleotides as biochemical probes; oligonucleotide derived diagnostics and therapeutics; anticancer-chemotherapeutic drug development; antiviral agent design and synthesis; intracellular target-mediated drug assembly; applications of nucleic acids analogues in nanotechnology; carbon nanotube nucleic acid interactions.

Donald E. Bergstrom

Design and synthesis of modified nucleosides and nucleotides as biochemical probes; oligonucleotide derived diagnostics and therapeutics; anticancer-chemotherapeutic drug development; antiviral agent design and synthesis; intracellular target-mediated drug assembly; applications of nucleic acids analogues in nanotechnology; carbon nanotube nucleic acid interactions.

Chen

We work on a broad range of problems, primarily involving the transport and conversion of energy carried by electrons, phonons, and photons. We seek to solve problems with high importance to applications in clean energy (e.g., direct energy conversion, hydrogen storage) and in major industrial segments (e.g., micro/nanoelectronics, sensors).

Tim Fisher

We work on a broad range of problems, primarily involving the transport and conversion of energy carried by electrons, phonons, and photons. We seek to solve problems with high importance to applications in clean energy (e.g., direct energy conversion, hydrogen storage) and in major industrial segments (e.g., micro/nanoelectronics, sensors).

Joseph

We develop nanotools and single molecule methods to understand intracellular biological mechanisms and interactions in realtime in single living cells using single molecule fluorescence methods, plasmonic sensing, and surface-enhanced Raman spectroscopy. We achieve this by integrating optics and instrumentation, nanomaterials with multifunctional properties, and single molecule and super-resolution fluorescence microscopy.

Joseph Irudayaraj

We develop nanotools and single molecule methods to understand intracellular biological mechanisms and interactions in realtime in single living cells using single molecule fluorescence methods, plasmonic sensing, and surface-enhanced Raman spectroscopy. We achieve this by integrating optics and instrumentation, nanomaterials with multifunctional properties, and single molecule and super-resolution fluorescence microscopy.

datta

Biomimetic surfaces, Scanning probe imaging and patterning, Biosensors and biomaterials

Albena Ivanisevic

Biomimetic surfaces, Scanning probe imaging and patterning, Biosensors and biomaterials

Fisher

I am interested in studying trafficking, differentiation, and effector function of immune cells and their progenitor cells. Current studies in the lab include: Mucosal versus Systemic Immunity and Inflammation, Functions of chemokines and chemokine receptors in immune cell trafficking, Trafficking and development of hematopoietic stem and progenitor cells, FoxP3+ regulatory T cells in health and diseases (autoimmune diseases and cancer), Follicular helper T cells in regulation of B cell responses, Migration and function of Th17 cells

Chang H. Kim

I am interested in studying trafficking, differentiation, and effector function of immune cells and their progenitor cells. Current studies in the lab include: Mucosal versus Systemic Immunity and Inflammation, Functions of chemokines and chemokine receptors in immune cell trafficking, Trafficking and development of hematopoietic stem and progenitor cells, FoxP3+ regulatory T cells in health and diseases (autoimmune diseases and cancer), Follicular helper T cells in regulation of B cell responses, Migration and function of Th17 cells

garcia

Fundamental topics are in biotechnology, bio-nanotechnology, bioproducts from agriculture and renewable resources, and biorecovery.

Michael Ladisch

Fundamental topics are in biotechnology, bio-nanotechnology, bioproducts from agriculture and renewable resources, and biorecovery.

Garimella

High-throughput and BioMEMS cell analysis and separation technologies for genomics and proteomics (cytomics)
High-speed imaging/laser ablation/laser opto-injection technologies for stem cell engineering
Nanomedicine approaches to cancer diagnostics and therapeutics, antiviral therapies, and regenerative medicine

James F. Leary

High-throughput and BioMEMS cell analysis and separation technologies for genomics and proteomics (cytomics)
High-speed imaging/laser ablation/laser opto-injection technologies for stem cell engineering
Nanomedicine approaches to cancer diagnostics and therapeutics, antiviral therapies, and regenerative medicine

McNally

Scanning Probe Microscopy (SPM); Atomic Force Microscopy (AFM); Magnetic Force Microscopy (MFM); Optimization and development of techniques for fluid applications; Neuroscience, Spinal Cord Injury; Nanomedicine; Cell Communications; Cell Biology; Cell Physiology; Hyperbaric, Conditions; Nanotechnology Education

Helen A. McNally

Scanning Probe Microscopy (SPM); Atomic Force Microscopy (AFM); Magnetic Force Microscopy (MFM); Optimization and development of techniques for fluid applications; Neuroscience, Spinal Cord Injury; Nanomedicine; Cell Communications; Cell Biology; Cell Physiology; Hyperbaric, Conditions; Nanotechnology Education

JP Allain

Research focus is on advanced physiological sensing technologies for research applications in biology, agriculture, and medicine

D. Marshall Porterfield

Research focus is on advanced physiological sensing technologies for research applications in biology, agriculture, and medicine

Lundstrom

Nonlinear and stochastic dynamics of micro and nano-oscillators, nanotube/nanowire vibrations, development of new imaging and force spectroscopy modes in dynamic Atomic Force Microscopy, dynamic AFM in liquids, nanobiomechanics, physics of adhesion and stiction at the micro and nanoscale, chem/bio sensing using micro and nanocantilevers, mechanics and reliability of RF MEMS, gas damping in MEMS/NEMS, reduced order modeling of MEMS/NEMS

Arvind Raman

Nonlinear and stochastic dynamics of micro and nano-oscillators, nanotube/nanowire vibrations, development of new imaging and force spectroscopy modes in dynamic Atomic Force Microscopy, dynamic AFM in liquids, nanobiomechanics, physics of adhesion and stiction at the micro and nanoscale, chem/bio sensing using micro and nanocantilevers, mechanics and reliability of RF MEMS, gas damping in MEMS/NEMS, reduced order modeling of MEMS/NEMS

Reifenberger

Research insterests include Scanning Tunneling Microscopy (STM) and Atomic Force Microscopy (AFM); nanometer-size clusters and cluster-assembled materials; electronic transport properties in nanowires; field emission; molecular electronics; nanoelectronics; and novel chem-bio sensing paradigms

Ron Reifenberger

Research insterests include Scanning Tunneling Microscopy (STM) and Atomic Force Microscopy (AFM); nanometer-size clusters and cluster-assembled materials; electronic transport properties in nanowires; field emission; molecular electronics; nanoelectronics; and novel chem-bio sensing paradigms

Rickus

The Rickus group specifically focuses on the design of new materials to measure, control, and mimic living cells. Materials are designed in the context of specific biological problems. We believe in a deep integration of cell biology with the materials, sensors, and actuators that we design.

Jenna Rickus

The Rickus group specifically focuses on the design of new materials to measure, control, and mimic living cells. Materials are designed in the context of specific biological problems. We believe in a deep integration of cell biology with the materials, sensors, and actuators that we design.

manfra

Biosensors, BioMEMS, Bionanotechnology, Protein detection, Cancer marker detection, Cell detection, DNA/RNA detection, Signal amplification, Integration of aptamers and aptazymes with micro/nano sensors, Nanomechanical sensors

Cagri Savran

Biosensors, BioMEMS, Bionanotechnology, Protein detection, Cancer marker detection, Cell detection, DNA/RNA detection, Signal amplification, Integration of aptamers and aptazymes with micro/nano sensors, Nanomechanical sensors

Mohammadi

Our Research is highly interdisciplinary and lays in the area of chemical synthesis of biologically inspired materials, biosensor, and biocatalyst platforms development, election microscopy of biomolecules, solid oxide fuel cells and high temperature ceramic processing.

Lia A. Stanciu

Our Research is highly interdisciplinary and lays in the area of chemical synthesis of biologically inspired materials, biosensor, and biocatalyst platforms development, election microscopy of biomolecules, solid oxide fuel cells and high temperature ceramic processing.

Reifenberger

Development of transiently-stable carrier systems for drug & gene delivery; supported membrane protein sensors for drug discovery; nanogel synthesis; 2D protein crystallization

David H. Thompson

Development of transiently-stable carrier systems for drug & gene delivery; supported membrane protein sensors for drug discovery; nanogel synthesis; 2D protein crystallization

rokhinson

Micro and Nanoscale fluid mechanics (microfluidics), MEMS, bio-MEMS, biological flows at the cellular level, micro-scale laminar mixing, physiological sensors, electrical and optical manipulation of particles and fluids, development of microfluidic diagnostic techniques.

Steven Wereley

Micro and Nanoscale fluid mechanics (microfluidics), MEMS, bio-MEMS, biological flows at the cellular level, micro-scale laminar mixing, physiological sensors, electrical and optical manipulation of particles and fluids, development of microfluidic diagnostic techniques.

Ye

Semiconductor physics and devices, Nano-structures and nano-fabrications, Quantum/spin-transport, Atomic layer deposition (ALD), High-k/III-V device integration, High-performance III-V MOSFETs, III-V FinFETs, High-k/graphene integration, High-performance graphene FETs, Graphene spintronics, ALD for solar applications

Peide Ye

Semiconductor physics and devices, Nano-structures and nano-fabrications, Quantum/spin-transport, Atomic layer deposition (ALD), High-k/III-V device integration, High-performance III-V MOSFETs, III-V FinFETs, High-k/graphene integration, High-performance graphene FETs, Graphene spintronics, ALD for solar applications

Schwartz

Biomedical micro and nanosystems, bioMEMS, implantable wireless microsystems, micro and nanofabrication technology, biomimetics, soft condensed matter, analog circuit design for biomedical applications .

Babak Ziaie

Biomedical micro and nanosystems, bioMEMS, implantable wireless microsystems, micro and nanofabrication technology, biomimetics, soft condensed matter, analog circuit design for biomedical applications.

 

BNC/NCN affiliated publications

(see all)

Boghossian, A.A., Choi, J.H., Ham, M.H. and Strano, M.S. Dynamic and Reversible Self-Assembly of Photoelectrochemical Complexes Based on Lipid Bilayer Disks, Photosynthetic Reaction Centers, and Single-Walled Carbon Nanotubes. Langmuir, 27(5), 1599-1609.

McCarthy, P.T., Otto, K.J. and Rao, M.P. Robust penetrating microelectrodes for neural interfaces realized by titanium micromachining. Biomedical Microdevices, 13(3), 503-515.

Book, B., Chen, J.J. and Irudayaraj, J. Quantification of Receptor Targeting Aptamer Binding Characteristics Using Single-Molecule Spectroscopy. Biotechnology and Bioengineering, 108(5), 1222-1227.

Carrasco, C., Luque, A., Hernando-Perez, M., Miranda, R., Carrascosa, J.L., Serena, P.A., de Ridder, M., Raman, A., Gomez-Herrero, J., Schaap, I.A.T., Reguera, D. and de Pablo, P.J. Built-In Mechanical Stress in Viral Shells. Biophysical Journal, 100(4), 1100-1108.

Cha, T.G., Baker, B.A., Sauffer, M.D., Salgado, J., Jaroch, D., Rickus, J.L., Porterfield, D.M. and Choi, J.H. Optical Nanosensor Architecture for Cell-Signaling Molecules Using DNA Aptamer-Coated Carbon Nanotubes. ACS Nano, 5(5), 4236-4244.

Chen, J.J.C.J.J., Nag, S., Vidi, P.A. and Irudayaraj, J. Single Molecule In Vivo Analysis of Toll-Like Receptor 9 and CpG DNA Interaction. Plos One, 6(4).

Claussen, J.C., Artiles, M.S., McLamore, E.S., Mohanty, S., Shi, J., Rickus, J.L., Fisher, T.S. and Porterfield, D.M. Electrochemical glutamate biosensing with nanocube and nanosphere augmented single-walled carbon nanotube networks: a comparative study. Journal of Materials Chemistry, 21(30), 11224-11231.

Claussen, J.C., Wickner, M.M., Fisher, T.S. and Porterfield, D.M. Transforming the Fabrication and Biofunctionalization of Gold Nanoelectrode Arrays into Versatile Electrochemical Glucose Biosensors. ACS Applied Materials & Interfaces, 3(5), 1765-1770.

Grafton, M.M.G., Wang, L., Vidi, P.A., Leary, J. and Lelievre, S.A. Breast on-a-chip: mimicry of the channeling system of the breast for development of theranostics. Integrative Biology, 3(4), 451-459.

Guo, C.L. and Irudayaraj, J. Fluorescent Ag Clusters via a Protein-Directed Approach as a Hg(II) Ion Sensor. Analytical Chemistry, 83(8), 2883-2889.

BNC-affiliated grants and contracts

(see all)

Reifenberger, Ronald G., from NaugaNeedles, $69,317, "The Design and Fabrication of Ultra-soft Scanning Probes for Use in the Study of Biological Samples Under Liquids."

Savran, Cagri A., from National Science Foundation, $270,000, "Hybrid Bionanomechanical Systems for Single Molecule Detection."

Ziaie, Babak, from Lilly (Eli) And Company, $115,918, "A Micropump for Cyrus Drug Delivery Device."

Leary, James F., from Techshot, $98,000, "Microfluidic Multichannel Flow Cytometer."

Irudayaraj, Joseph M. K., from Phs-Nih Nat Inst Of Environment Hlth Sci., $148,307, "Chemical Mapping of Chromate Uptake, Localization, and Reduction in Remediating Bacteria using Surface-Enhanced Raman Scattering Substrates."

Wereley, Steven T., from IKOtech, LLC., $16,401, "Magnetic Purification of Stem Cells from Cord Blood."

Leary, James F., from Dow Agrosciences, $113,823, "Construction of DNA/CPP/fusion-tag tethered nanoparticles for the plant cell delivery, genome modification and transgene expression."

 

BNC Research

 

For More Information,
Please Contact:

Monica M.C. Allain, Ph.D.
Managing Director
Ph: 765-494-5138
mallain@purdue.edu

 

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