Researchers have developed a new type of pump for drug-delivery patches that might use arrays of "microneedles" to deliver a wider range of medications than now possible with conventional patches.
A researcher has developed probes that can help pinpoint the location of tumors and might one day be able to directly attack cancer cells.
Researchers have created a precise biosensor for detecting blood glucose and potentially many other biological molecules by using hollow structures called single-wall carbon nanotubes anchored to gold-coated "nanocubes."
Theory, simulation, characterization, and compact modeling of semiconductor electronic, optoelectronic, and bio-electronic devices
Theory, simulation, characterization, and compact modeling of semiconductor electronic, optoelectronic, and bio-electronic devices
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Design and synthesis of modified nucleosides and nucleotides as biochemical probes; oligonucleotide derived diagnostics and therapeutics; anticancer-chemotherapeutic drug development; antiviral agent design and synthesis; intracellular target-mediated drug assembly; applications of nucleic acids analogues in nanotechnology; carbon nanotube nucleic acid interactions.
Design and synthesis of modified nucleosides and nucleotides as biochemical probes; oligonucleotide derived diagnostics and therapeutics; anticancer-chemotherapeutic drug development; antiviral agent design and synthesis; intracellular target-mediated drug assembly; applications of nucleic acids analogues in nanotechnology; carbon nanotube nucleic acid interactions.
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We work on a broad range of problems, primarily involving the transport and conversion of energy carried by electrons, phonons, and photons. We seek to solve problems with high importance to applications in clean energy (e.g., direct energy conversion, hydrogen storage) and in major industrial segments (e.g., micro/nanoelectronics, sensors).
We work on a broad range of problems, primarily involving the transport and conversion of energy carried by electrons, phonons, and photons. We seek to solve problems with high importance to applications in clean energy (e.g., direct energy conversion, hydrogen storage) and in major industrial segments (e.g., micro/nanoelectronics, sensors).
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We develop nanotools and single molecule methods to understand intracellular biological mechanisms and interactions in realtime in single living cells using single molecule fluorescence methods, plasmonic sensing, and surface-enhanced Raman spectroscopy. We achieve this by integrating optics and instrumentation, nanomaterials with multifunctional properties, and single molecule and super-resolution fluorescence microscopy.
We develop nanotools and single molecule methods to understand intracellular biological mechanisms and interactions in realtime in single living cells using single molecule fluorescence methods, plasmonic sensing, and surface-enhanced Raman spectroscopy. We achieve this by integrating optics and instrumentation, nanomaterials with multifunctional properties, and single molecule and super-resolution fluorescence microscopy. |
Biomimetic surfaces, Scanning probe imaging and patterning, Biosensors and biomaterials
Biomimetic surfaces, Scanning probe imaging and patterning, Biosensors and biomaterials |
I am interested in studying trafficking, differentiation, and effector function of immune cells and their progenitor cells. Current studies in the lab include: Mucosal versus Systemic Immunity and Inflammation, Functions of chemokines and chemokine receptors in immune cell trafficking, Trafficking and development of hematopoietic stem and progenitor cells, FoxP3+ regulatory T cells in health and diseases (autoimmune diseases and cancer), Follicular helper T cells in regulation of B cell responses, Migration and function of Th17 cells I am interested in studying trafficking, differentiation, and effector function of immune cells and their progenitor cells. Current studies in the lab include: Mucosal versus Systemic Immunity and Inflammation, Functions of chemokines and chemokine receptors in immune cell trafficking, Trafficking and development of hematopoietic stem and progenitor cells, FoxP3+ regulatory T cells in health and diseases (autoimmune diseases and cancer), Follicular helper T cells in regulation of B cell responses, Migration and function of Th17 cells |
Fundamental topics are in biotechnology, bio-nanotechnology, bioproducts from agriculture and renewable resources, and biorecovery.
Fundamental topics are in biotechnology, bio-nanotechnology, bioproducts from agriculture and renewable resources, and biorecovery. |
High-throughput and BioMEMS cell analysis and separation technologies for genomics and proteomics (cytomics)
High-speed imaging/laser ablation/laser opto-injection technologies for stem cell engineering Nanomedicine approaches to cancer diagnostics and therapeutics, antiviral therapies, and regenerative medicine High-throughput and BioMEMS cell analysis and separation technologies for genomics and proteomics (cytomics) High-speed imaging/laser ablation/laser opto-injection technologies for stem cell engineering Nanomedicine approaches to cancer diagnostics and therapeutics, antiviral therapies, and regenerative medicine |
Scanning Probe Microscopy (SPM); Atomic Force Microscopy (AFM); Magnetic Force Microscopy (MFM); Optimization and development of techniques for fluid applications; Neuroscience, Spinal Cord Injury; Nanomedicine; Cell Communications; Cell Biology; Cell Physiology; Hyperbaric, Conditions; Nanotechnology Education
Scanning Probe Microscopy (SPM); Atomic Force Microscopy (AFM); Magnetic Force Microscopy (MFM); Optimization and development of techniques for fluid applications; Neuroscience, Spinal Cord Injury; Nanomedicine; Cell Communications; Cell Biology; Cell Physiology; Hyperbaric, Conditions; Nanotechnology Education |
Research focus is on advanced physiological sensing technologies for research applications in biology, agriculture, and medicine
Research focus is on advanced physiological sensing technologies for research applications in biology, agriculture, and medicine |
Nonlinear and stochastic dynamics of micro and nano-oscillators, nanotube/nanowire vibrations, development of new imaging and force spectroscopy modes in dynamic Atomic Force Microscopy, dynamic AFM in liquids, nanobiomechanics, physics of adhesion and stiction at the micro and nanoscale, chem/bio sensing using micro and nanocantilevers, mechanics and reliability of RF MEMS, gas damping in MEMS/NEMS, reduced order modeling of MEMS/NEMS
Nonlinear and stochastic dynamics of micro and nano-oscillators, nanotube/nanowire vibrations, development of new imaging and force spectroscopy modes in dynamic Atomic Force Microscopy, dynamic AFM in liquids, nanobiomechanics, physics of adhesion and stiction at the micro and nanoscale, chem/bio sensing using micro and nanocantilevers, mechanics and reliability of RF MEMS, gas damping in MEMS/NEMS, reduced order modeling of MEMS/NEMS
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Research insterests include Scanning Tunneling Microscopy (STM) and Atomic Force Microscopy (AFM); nanometer-size clusters and cluster-assembled materials; electronic transport properties in nanowires; field emission; molecular electronics; nanoelectronics; and novel chem-bio sensing paradigms
Research insterests include Scanning Tunneling Microscopy (STM) and Atomic Force Microscopy (AFM); nanometer-size clusters and cluster-assembled materials; electronic transport properties in nanowires; field emission; molecular electronics; nanoelectronics; and novel chem-bio sensing paradigms
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The Rickus group specifically focuses on the design of new materials to measure, control, and mimic living cells. Materials are designed in the context of specific biological problems. We believe in a deep integration of cell biology with the materials, sensors, and actuators that we design.
The Rickus group specifically focuses on the design of new materials to measure, control, and mimic living cells. Materials are designed in the context of specific biological problems. We believe in a deep integration of cell biology with the materials, sensors, and actuators that we design. |
Biosensors, BioMEMS, Bionanotechnology, Protein detection, Cancer marker detection, Cell detection, DNA/RNA detection, Signal amplification, Integration of aptamers and aptazymes with micro/nano sensors, Nanomechanical sensors Biosensors, BioMEMS, Bionanotechnology, Protein detection, Cancer marker detection, Cell detection, DNA/RNA detection, Signal amplification, Integration of aptamers and aptazymes with micro/nano sensors, Nanomechanical sensors |
Our Research is highly interdisciplinary and lays in the area of chemical synthesis of biologically inspired materials, biosensor, and biocatalyst platforms development, election microscopy of biomolecules, solid oxide fuel cells and high temperature ceramic processing. Our Research is highly interdisciplinary and lays in the area of chemical synthesis of biologically inspired materials, biosensor, and biocatalyst platforms development, election microscopy of biomolecules, solid oxide fuel cells and high temperature ceramic processing. |
Development of transiently-stable carrier systems for drug & gene delivery; supported membrane protein sensors for drug discovery; nanogel synthesis; 2D protein crystallization
Development of transiently-stable carrier systems for drug & gene delivery; supported membrane protein sensors for drug discovery; nanogel synthesis; 2D protein crystallization |
Micro and Nanoscale fluid mechanics (microfluidics), MEMS, bio-MEMS, biological flows at the cellular level, micro-scale laminar mixing, physiological sensors, electrical and optical manipulation of particles and fluids, development of microfluidic diagnostic techniques.
Micro and Nanoscale fluid mechanics (microfluidics), MEMS, bio-MEMS, biological flows at the cellular level, micro-scale laminar mixing, physiological sensors, electrical and optical manipulation of particles and fluids, development of microfluidic diagnostic techniques. |
Semiconductor physics and devices, Nano-structures and nano-fabrications, Quantum/spin-transport, Atomic layer deposition (ALD), High-k/III-V device integration, High-performance III-V MOSFETs, III-V FinFETs, High-k/graphene integration, High-performance graphene FETs, Graphene spintronics, ALD for solar applications
Semiconductor physics and devices, Nano-structures and nano-fabrications, Quantum/spin-transport, Atomic layer deposition (ALD), High-k/III-V device integration, High-performance III-V MOSFETs, III-V FinFETs, High-k/graphene integration, High-performance graphene FETs, Graphene spintronics, ALD for solar applications
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Biomedical micro and nanosystems, bioMEMS, implantable wireless microsystems, micro and nanofabrication technology, biomimetics, soft condensed matter, analog circuit design for biomedical applications .
Biomedical micro and nanosystems, bioMEMS, implantable wireless microsystems, micro and nanofabrication technology, biomimetics, soft condensed matter, analog circuit design for biomedical applications.
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Boghossian, A.A., Choi, J.H., Ham, M.H. and Strano, M.S. Dynamic and Reversible Self-Assembly of Photoelectrochemical Complexes Based on Lipid Bilayer Disks, Photosynthetic Reaction Centers, and Single-Walled Carbon Nanotubes. Langmuir, 27(5), 1599-1609.
McCarthy, P.T., Otto, K.J. and Rao, M.P. Robust penetrating microelectrodes for neural interfaces realized by titanium micromachining. Biomedical Microdevices, 13(3), 503-515.
Book, B., Chen, J.J. and Irudayaraj, J. Quantification of Receptor Targeting Aptamer Binding Characteristics Using Single-Molecule Spectroscopy. Biotechnology and Bioengineering, 108(5), 1222-1227.
Carrasco, C., Luque, A., Hernando-Perez, M., Miranda, R., Carrascosa, J.L., Serena, P.A., de Ridder, M., Raman, A., Gomez-Herrero, J., Schaap, I.A.T., Reguera, D. and de Pablo, P.J. Built-In Mechanical Stress in Viral Shells. Biophysical Journal, 100(4), 1100-1108.
Cha, T.G., Baker, B.A., Sauffer, M.D., Salgado, J., Jaroch, D., Rickus, J.L., Porterfield, D.M. and Choi, J.H. Optical Nanosensor Architecture for Cell-Signaling Molecules Using DNA Aptamer-Coated Carbon Nanotubes. ACS Nano, 5(5), 4236-4244.
Chen, J.J.C.J.J., Nag, S., Vidi, P.A. and Irudayaraj, J. Single Molecule In Vivo Analysis of Toll-Like Receptor 9 and CpG DNA Interaction. Plos One, 6(4).
Claussen, J.C., Artiles, M.S., McLamore, E.S., Mohanty, S., Shi, J., Rickus, J.L., Fisher, T.S. and Porterfield, D.M. Electrochemical glutamate biosensing with nanocube and nanosphere augmented single-walled carbon nanotube networks: a comparative study. Journal of Materials Chemistry, 21(30), 11224-11231.
Claussen, J.C., Wickner, M.M., Fisher, T.S. and Porterfield, D.M. Transforming the Fabrication and Biofunctionalization of Gold Nanoelectrode Arrays into Versatile Electrochemical Glucose Biosensors. ACS Applied Materials & Interfaces, 3(5), 1765-1770.
Grafton, M.M.G., Wang, L., Vidi, P.A., Leary, J. and Lelievre, S.A. Breast on-a-chip: mimicry of the channeling system of the breast for development of theranostics. Integrative Biology, 3(4), 451-459.
Guo, C.L. and Irudayaraj, J. Fluorescent Ag Clusters via a Protein-Directed Approach as a Hg(II) Ion Sensor. Analytical Chemistry, 83(8), 2883-2889.
Reifenberger, Ronald G., from NaugaNeedles, $69,317, "The Design and Fabrication of Ultra-soft Scanning Probes for Use in the Study of Biological Samples Under Liquids."
Savran, Cagri A., from National Science Foundation, $270,000, "Hybrid Bionanomechanical Systems for Single Molecule Detection."
Ziaie, Babak, from Lilly (Eli) And Company, $115,918, "A Micropump for Cyrus Drug Delivery Device."
Leary, James F., from Techshot, $98,000, "Microfluidic Multichannel Flow Cytometer."
Irudayaraj, Joseph M. K., from Phs-Nih Nat Inst Of Environment Hlth Sci., $148,307, "Chemical Mapping of Chromate Uptake, Localization, and Reduction in Remediating Bacteria using Surface-Enhanced Raman Scattering Substrates."
Wereley, Steven T., from IKOtech, LLC., $16,401, "Magnetic Purification of Stem Cells from Cord Blood."
Leary, James F., from Dow Agrosciences, $113,823, "Construction of DNA/CPP/fusion-tag tethered nanoparticles for the plant cell delivery, genome modification and transgene expression."
Monica M.C. Allain, Ph.D.
Managing Director
Ph: 765-494-5138
mallain@purdue.edu
