Birck Nanotechnology Center

BNC CTSI Facilities

BRK 2031: Nanochemistry/Nanoelectronics

Rating: General Lab

This laboratory enables synthesis, processing and/or functionalization of carbon nanotubes, iron oxide nanopartices, and semiconductor nanocrystals. Existing equipment within this lab includes three glove box isolation areas, a UV/ozone etcher, and a Chemical Mechanical Polisher (CMP) system which allows users to prepare wafers and subsequently microchips for MEMS devices. This lab also houses eight chemical fume hoods (including two walk-in hoods) that provide workspace for KOH etching and acid-bath washing.

FIC: Prof. David Janes, Prof. Donald Bergstrom
SIC: Lisa Reece, Christy Cooper

BRK 2037: Chemical Nanotechnology/Microfluidics

Rating: General Lab

This lab houses FTIR, DLS, and ellipsometry capabilities, allowing surface analyses of nanoparticles and wafers, such as those made in BRK 2031. This lab also provides facilities for studying conformational flexibility of DNA nanostructres and other biological molecules, as well as facilities for studying the physics involved in making successful BioMEMS/BioNEMS devices, including some with drug delivery capabilities. Microfluidics devices are coupled with a microscope and laser capabilities for holographic optical trapping studies.

FIC: Prof. Alex Ribbe, Prof. Steve Wereley
SIC: Lisa Reece, Christy Cooper

BRK 2077: Biosensors/Nanomechanical Sensing/Protein Detection

Rating: BSL-1 (Future BSL-2)

This BSL-1 lab houses equipment for studies of biosensor, BioMEMS, and BioNanotechnology, protein and cancer marker detection with nanomechanical sensors. Current research utilizes laser-based systems are used to determine biomarker concentrations on cells using microscopic magnetic beads assembled to form a structure called a "diffraction grating." The laser beam is focused on the grating which yields a pattern that could potentially be used to determine the biomaker concentration and thus the state of tumor growth. There are currently two chemical fume hoods available for standard chemical processes. A Class II biological safety cabinet has been installed into this laser lab and soon, the lab will be upgraded to a BSL-2 facility.

FIC: Prof. Cagri Savran
SIC
: Lisa Reece, Christy Cooper

BRK 2081: Translational BioMEMS

Rating: BSL-1

This BSL-1 laboratory is centered on BioMEMS and nanotechnology. This research includes biomimetic devices, wireless dosimetry, and ferrofluid platforms. The lab houses a new spinner which, coupled with the equipment avaiable in BRK 2031, allows users to generate their own wafer designs and make PDMS microfluidic chip devices. These devices could be taken into BRK 2037 for surface analyses and/or into BRK 2043 and/or BRK 2087 for use in cell systems.

FIC: Prof. Babak Ziaie
SIC
: Lisa Reece, Christy Cooper

BRK 2043: Mammalian/Human Culture/Advanced BioMEMS

Rating: BSL-2

This lab houses CO2 incubators, Class II biological safety cabinets (one for infectious work), electrophoresis equipment, one tissue culture microscope, and microcentrifuges available for aseptic mammalian and human cell culture work. This is a BSL-2 facility capable of handling any infectious work within this classification. Users can take nanoparticles, usch as those made in BRK 2031 and characteried in BRK 2037, and flow these cell types in lab-on-a-chip devices, such as those designed and manufactured within BRK 2031 (CMP, glove boxes, KOH etching hoods) and BRK 2081 (spinner). There are also two fume hoods that have been capped off from the HVAC supply inorder to provide workspace to sustain DNA/RNA/microfluidics testing experiments.

FIC: Prof. James Leary
SIC
: Lisa Reece, Christy Cooper

BRK 2087: Plant/Bacterial Bioprocessing/BioMEMS Device Testing

Rating: BSL-2

This BSL-2 lab is set up for plant and/or bacterial cell cultures (completely separate from BRK 2043). This lab has equipment for CO2 incubation, room temperature or higher culture incubation environments for bacterial plates, and two variable temperature/varible speed shaking waterbaths for culturing purposes. This lab contains two separate, lockable rooms - one where pathogenic bacteria may safely be cultured and worked with, and one where plant cells can be separately cultured. The main lab houses one UV/VIS spectrophometer, microcentrifuges, electrophoresis equipment, one Nikon Eclipse E600 fluorescent microscope, two Class II biological safety cabinets (one for pathogenic work), and one capped-off fume hood that is funtioning as a workstation for DNA/RNA work.

FIC: Prof. James Leary
SIC
: Lisa Reece, Christy Cooper

Biocleanroom

The BNC biocleanroom is a portion of the Scifres Nanofabrication Laboratory that also contains the nanofabrication cleanroom. It consists of a 2500 ft2 ISO Class 5 (Class 1,000) cleanroom facility using a specially designed ceiling, wall, and floor system to minimize bacterial entrainment and enhance cleanability. Like all BNC laboratories, it is a shared facility that can be customized to the needs of the researchers.

BRK 2120: Biocleanroom (BCR) Facility

Rating: TBE

This biocleanroom is for further cleanroom-level bioprocessing, sterility testing, and testing of BioMEMS devicies, BioNEMS devices, and implantable microdevices. This biocleanroom provides capabilities for device development and testing that requice a level of cleanliness that is not satisfied by the capabilities of other BNC biological laboratories. It also provides a material pass-through to/from the nanofabrication cleanroom, allowing transport of fabricated devices without breaking cleanliness. It can be confugured to a BSL-1 and/or BSL-2 capabilities depending on research needs.

FIC: Prof. James Leary
SIC
: Lisa Reece, John Weaver

BRK 1081: Atomic Force Microscopy

Rating: BSL-1

This lab provides analysis of biological (non-infectious and non-hazardous plant and animal) and non-biological samples. The AFMs are configured for liquid media, internal resonance, bimodal applications, and multi-modal dynamics in liquid/ambient environments.

FIC: Prof. Arvind Raman, Prof. Ron Reifenberger
SIC
: Lisa Reece, Christy Cooper, Xin Xu

BRK 1087: BioAtomic Force Microscopy

Rating: BSL-2

This is the future home of the Veeco BioScope AFM. This lab will be fitted with a Class II biological safety cabinet to allow work on infectious and non-infectious mammalian, bacterial, and human samples. Users will be able to bring their samples that they have generated and characterized from the second floor east wing of the Birck Center, to this lab for AFM imaging analysis and processing.

FIC: Prof. Helen McNally
SIC
: Lisa Reece, Christy Cooper, Xin Xu

CTSI Links