Discovery Park

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Discovery Park researchers Jiri Adamec, left, and Maria Sepulveda analyze molecule samples taken using gas chromatography coupled with a mass spectrometer at a laboratory in Discovery Park's Bindley Bioscience Center.

Adamec, a faculty researcher in metabolomics and proteomics, and Sepulveda, an assistant professor in the Department of Forestry and Natural Resources, are examining the development of biomarkers in fish that have been exposed to chemicals and contaminants such as herbicides. The research has applications in how humans might adversely react to the same chemicals.

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Arun Bhunia (standing) and Padmapriya Banada use a laser and a computer monitor to observe scatter patterns in a petri dish in their Purdue University lab.

The technique may provide cost-cutting applications for medicine, food processing and homeland security. Bhunia is a professor of food microbiology, and Banada is a postdoctoral researcher. (Purdue University photo/Tom Campbell.)

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\"A little juice in your hot tea may increase the amount of tea-derived antioxidants that your body is able to absorb\", said Purdue associate professor of food science Mario Ferruzzi.

His study found lemon juice had the most profound impact, followed by orange, lime and grapefruit juices. Molecular components were determined in the metabolite profiling facility at the Bindley Bioscience Center.

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Dr. Nancy Ho has developed the world's most efficient microorganism for conversion of cellulose to ethanol.

The 'Purdue Ho yeast' has been licensed by several companies for biofuels production and application of this technology is provided in Green Tech America, LLC., a company founded by Dr. Ho. Development of desired traits in this yeast strain continue with research in the Bindley Center funded by two Dept of Energy awards to Dr. Ho and Bindley Lead Scientist Jiri Adamec.

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Pedro Irazoqui, an assistant professor of biomedical engineering at Purdue, uses a \"radio frequency probe station\" to test tiny circuits in a new miniature device designed to be implanted in the brain to predict epileptic seizures.

The research focuses on a transmitter three times the width of a human hair to be implanted below the scalp to detect the signs of a seizure before it occurs. The system will record neural signals relayed by electrodes in various points in the brain.

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Dr. Sophie Lelièvre discusses the mechanisms by which the organization of components of the cell nucleus directs the expression and stability of the genome.

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Dr. Sophie Lelièvre views three-dimensional cultures of non-malignant and malignant breast epithelial cells that recapitulate the formation of normal tissue structures (mammary alveoli) and tumor nodules, respectively.

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A graduate student in Dr. Sophie Lelièvre's lab cultures breast epithelial cells.

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Chang Lu (right), a professor of agricultural and biological engineering, and graduate student, Jun Wang, run a test on their microfluidic chip that fuses cells.

A growing research technology, cell fusing is vital in studying stem cells, creating clones and finding disease antibodies. (Purdue Agricultural Communication photo/Tom Campbell)

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Marshall Porterfield, associate professor of agricultural and biological engineering, floats in the \"vomit comet\" A NASA-modified DC-9 with reduced gravity environment.

Dr. Porterfield suggests that plants sense gravity through a process that develops a bioelectric field within plant cells. He and colleagues test a new type of biosensor capable of measuring ion currents in multiple locations around a single cell in this microgravity environment. The MISA chip - for microfluidic ion sensor array - is a collection of sensors that detect ion motion in very small volumes of a sample.

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Professor David Salt (HORT) has pioneered high throughput profiling of metal ion content in biological systems.

Monitoring the 'ionome' indicates health and disease in plants and animals. A database for ion content measurement, the Purdue ionomics information management system (Piims), was developed at Discovery Park and is the most accessed tool of its kind in the field.

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Dr. Cynthia Stauffacher discusses the application of x-ray crystallography and molecular biology to systems where proteins work together in membranes to perform a biological function.

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Dr. Jiri Adamec uses mass spectrometry to evaluate chemopreventative effect of medicinal and edible mushroom extracts against dietary-and inflammation-induced colon carcinogenesis.

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Dr. Jiri Adamec (left) and Fred Regnier examine biomarker data obtained from mass spectrometry based proteomics studies.

These investigators are working with a National Cancer Institute funded consortium to evaluate cancer biomarker technology for clinical utility. The team in this National Center led by Dr. Regnier, has identified biomarkers in breast and prostate cancer that will be validated with follow on studies.


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Graduate student of Dr. Don Bergstrom investigates the Medicinal and Bioorganic Chemistry of Nucleic Acids.

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Dr. Ji-Xin Cheng develops state-of-the-art optical imaging techniques and bionanotechnology to tackle compelling biomedical problems highly related to human health including intravital flow detection of tumor cells.

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Dr. Joseph Irudayaraj's group is developing single molecule methods for cell surface and intracellular receptor oligomerization and single particle sensors for targeted treatment of breast cancer.

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\"We can now clearly understand how these proteins interact with one another,' said Richard J. Kuhn (left), a professor of biological sciences and Director of the Bindley Bioscience Center. 'We can't cure West Nile yet, but we can now start thinking about how to interfere with these interactions, which could be a key to stopping the infection's progress.'

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Dr. Phil Low presents translational cancer research to clinicians at a Cancer Research Clinical Partnership meeting.

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Clinician presents a ovarian cancer case to Purdue cancer researchers at a Cancer Research Clinical Partnership meeting.

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Researchers interact with clinicians at a Cancer Research Clinical Partnership meeting.

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Current vaccines against human cases of bird flu, or avian influenza, are effective only against specific strains of these illnesses.

Purdue University molecular virologist Suresh Mittal and collaborators are investigating using a harmless virus, called an adenovirus, as a delivery vehicle to develop vaccines that will continue to provide protection as influenza strains mutate.

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Dr. Dan Raftery discussed the combination of NMR and multivariate statistical analysis as a new way to analyze complex samples such as biofluids.

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Dr. Dan Raftery laboratory investigates the field of metabolomics and the implications for early disease detection.

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Graduate students in Dr. Dan Raftery's lab analyze serum using metabolomics to identify potential biomarkers of disease.

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Bindley Bioscience researchers Catherine Riley and Xiang Zhang collect human tears for a project to monitor health and disease status by evaluating the protein and metabolite content of tears.

This project is creating a tear proteome database to catalog proteins found in this fluid in healthy individuals.

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J. Paul Robinson, a Purdue professor of veterinary medicine, makes an adjustment on the multispectral analysis instrument in his laboratory at Discovery Park's Bindley Bioscience Center.

Robinson is the principal investigator for a project funded by the Howard Hughes Medical Institute that helps middle school students learn about science with electronic field trips

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Vitamin D status is associated with a reduced incidence of several cancers, including prostate, colon and breast cancer. Dr. Dorothy Teegarden's laboratory is investigating the role and the mechanism of vitamin D metabolites in the growth and programmed cell death of cells.

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The Bioscope II is the world's most advanced atomic force microscope (AFM) that is compatible with measurement from living biological systems.

The Bindley Center was the first academic laboratory in the world to obtain the Bioscope II as a beta-prototype instrument in cooperation with the vendor company Veeco. This AFM enables measurement of atomic distance and forces in living cells in real time.

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The Bindley Bioscience Center at Purdue's Discovery Park blends life sciences and engineering research to cultivate and support innovative, multi-investigator, interdisciplinary research teams.

The Bindley engages biosciences in a broader perspective with applications of new or emerging technologies. The Center has established new research infrastructure to apply analytical methods, precision measurement technologies and high throughput approaches to biological systems.

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The BioCD, invented by Drs. Fred Regnier and David Nolte enables label-free detection of biomolecular interactions in a fast, inexpensive and highly sensitive format. The technology utilizes interferometry (essentially reflected light) to detect changes in height of biomolecule arrays printed on a reflective surface.

This technology spawned the company Quadraspec in Purdue Research Park that is now producing BioCD products for verterinary diagnosis. Four active research grants with Quadraspec are underway in the Bindley Center to further develop the sensitivity of this technology and to move the technology into human diagnostic applications.

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About Discovery Park

Discovery Park and its major centers lead Purdue's large-scale interdisciplinary research efforts.

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Discovery Park
610 Purdue Mall
West Lafayette, IN 47907