The 5th Annual Symposium at Purdue University will cover an overview of the agronomic, fuel infrastructure and economic context of biofuels production, and focus on second-generation and third-generation (drop-in) advanced biofuels from biological and chemical/thermal conversion pathways. The meeting is hosted jointly by two recently funded DOE-Office of Science “Energy Frontier Research Centers” (C3Bio and IACT) and sponsored by Purdue University.