Research areas represent interdisciplinary expertise on the Purdue campus that transcends traditional academic boundaries to provide synergistic
capabilities for life sciences projects at the Bindley Bioscience Center, particularly those focused on health and disease research. Each
research area is a different cross-section of academic disciplines that, when integrated with the new core technologies in the Bindley Bioscience
Center, will have a high impact on society through the generation of new scientific knowledge, the development of new technologies, and
the promotion of commercializable discoveries for use in promoting human health.
Interested in engaging in research with the Bindley Bioscience Center? Learn how to participate or learn more about projects
In the United States and most Western countries, diet-related chronic diseases represent the single largest cause of morbidity
and mortality. These diseases are epidemic in contemporary Westernized populations and typically afflict 50-65% of the adult population.
All diet-associated diseases have multifactorial dietary contributions that underlie their etiology, along with other environmental
agents and genetic susceptibility. The Bindley Bioscience Center is taking on the challenges in this area by applying the emerging
biological, analytical and bioinformatics tools used for the study of biological systems to the multifaceted molecular interconnections
between diet, disease and health. The mechanistic connections between dietary components and specific diseases are generally not
well understood. Knowledge generated in this research area will allow the identification of novel molecular pathways connecting
diet with particular disease and health states. This research will translate to the development of novel food products to reduce
Capitalizing upon the historic strengths at Purdue University in pharmaceutical sciences, chemistry, structural biology, and
basic medical sciences, the Bindley Bioscience Center coalesces expertise and capabilities in systems engineering and nanotechnology
to identify and develop new drug entities and more successful systems for delivery of drugs. An integrated approach combines the
capacity of the Core Technologies with biological systems-based assays to enable new platforms for high throughput screening of
candidate chemicals and biologics of potential use in research as well as for treatments or preventative agents. These capabilities
will also be applied to the development of novel drug delivery approaches, especially those utilizing nanotechnology.
The Bindley Bioscience Center has established a focus on measurement systems, particularly the innovative application of technologies
in biological systems to identify and characterize biomarkers of both disease and health. Biomarkers are substances that may be
detected in bodily fluids or tissues and that provide a signature of the status of a patient with respect to disease diagnosis,
prognosis or therapeutic efficacy. The importance of biomarkers is underscored by the dawning of "personalized medicine"
in which the individual, not a generic disease, becomes the focus of treatment. Projects aimed at discovery and clinical validation
of molecular entities are central to this research area and include the development and implementation of new detection technologies
and information systems for application in translational research.
Opportunities to advance bioscience research with technology development at the atomic and molecular scale are increasingly
recognized, particularly in pursuit of new diagnostics and therapeutics. Nanomedicine lies at the interface of recent advancements
in nanoscale science and biological systems. The Bindley Bioscience Center capitalizes on Purdue University's strengths in
micro and nano-scale engineering and the capacity of the Birck Nanotechnology Center by integrating technology development with
translational research to directly address problems of central importance to clinical science. Translational nanotechnology development
includes the use of nanoscale drug delivery devices for targeted therapy, micro and nano-structured surfaces for tissue engineering,
development of artificial organs and devices using micro-nano fabrication and scaffolding techniques, and miniature drug screening
platforms. Scientific exploration of biological and biomedical applications of nanotechnology enables research projects in discovery
and advancements in the Center's other interdisciplinary research areas. Approaches include microfluidic 'lab-on-a-chip'
detection systems; tissue and cellular biosensor development and application; biopolymers for nanofabrication and detection schemes;
and innovative optic/photonic methods for biomarker discovery and development.
Innovative Instrument Development brings together chemists, physicist, engineers, biologist, and physicians from multiple Schools at Purdue University and other institutions in the region. The center develops innovative "machine-tools of science" that enable discoveries across a broad spectrum of life science. These activities will lead to routing, point-of-need devices for use in drug discovery, clinical diagnostics, environmental monitoring, and the fight against chemical and biological terrorism