Decoding Dengue and West Nile
February 20, 2014
WEST LAFAYETTE, Ind. — A team of scientists from Purdue University and the University of Michigan have captured the structure of a protein that could lead to new treatments for dengue and West Nile viruses.
Researchers have pursued this protein for years because both its role in replication and its unique release into the bloodstream mark it as a target for treatment of infection, said Richard Kuhn, professor and department head of biological sciences and the Gerald and Edna Mann Director of the Bindley Bioscience Center at Purdue.
"Having the structure of NS1 is a huge advance in understanding, and using, the protein to our advantage," said Kuhn, who led the Purdue team involved in the work. "Understanding how the protein is designed provides an easier pathway to understanding its roles in the virus life cycle. We now know which portions of the protein to target in drug development to shut it down and stop the progression of infection."
A paper detailing the research was published in the journal Science and is available online. In addition to Kuhn, Purdue research associate Joyce Jose is a co-author.
December 18, 2014
Three Purdue University professors have been named fellows of the National Academy of Inventors.Read Full Story
December 5, 2014
Postdoctoral researchers at Purdue University will have a chance to gain valuable proposal writing and reviewing experience in translational research, as well as the chance to win $5,000 for their own research, through the Purdue Postdoc Challenge.Read Full Story
November 14, 2014
The Purdue administration of the Indiana Clinical and Translational Sciences Institute (Indiana CTSI) is offering post-doctoral investigators two $5000 grants for the use of specific Purdue core facilities.Read Full Story