Decoding Dengue and West Nile
February 20, 2014
WEST LAFAYETTE, Ind. — A team of scientists from Purdue University and the University of Michigan have captured the structure of a protein that could lead to new treatments for dengue and West Nile viruses.
Researchers have pursued this protein for years because both its role in replication and its unique release into the bloodstream mark it as a target for treatment of infection, said Richard Kuhn, professor and department head of biological sciences and the Gerald and Edna Mann Director of the Bindley Bioscience Center at Purdue.
"Having the structure of NS1 is a huge advance in understanding, and using, the protein to our advantage," said Kuhn, who led the Purdue team involved in the work. "Understanding how the protein is designed provides an easier pathway to understanding its roles in the virus life cycle. We now know which portions of the protein to target in drug development to shut it down and stop the progression of infection."
A paper detailing the research was published in the journal Science and is available online. In addition to Kuhn, Purdue research associate Joyce Jose is a co-author.
July 9, 2014
Moments after Dr. Jeff Crecelius completes a surgery, hopeful family members typically want to know if he was able to "get it all," or remove all of the cancerous tumor from the brain of a loved one. It's their emotional plea for reassurance. They want to know that the ordeal is completed and that the brain tumor has met its match — the hands of a skilled surgeon.Read Full Story
May 13, 2014
A new alliance focused on aligning resources to advance early stage drug development at top research universities across the state announced its first request for proposals during a retreat hosted by the Indiana Clinical and Translational Sciences Institute at Purdue in West Lafayette, Ind.Read Full Story
April 23, 2014
Purdue University researchers have developed a way to detect and measure cancer levels in a living cell by using tiny gold particles with tails of synthetic DNA.Read Full Story