Purdue researchers apply new technique to manipulate virus, make it a possible cancer treatment
November 27, 2013
WEST LAFAYETTE, Ind. — Purdue University researchers successfully eliminated the native infection preferences of a Sindbis virus engineered to target and kill cancer cells, a milestone in the manipulation of this promising viral vector.
"This virus had been known to be a good vector for delivering therapeutic cargo, however it naturally infected all kinds of cells, and these diversions would compete with what we were instructing it to target," said Richard Kuhn, the Gerald and Edna Mann Director of Purdue's Bindley Biosciences Center. "We have now overcome a major challenge by not only inserting a targeting molecule of our choice, but also successfully stripping the virus of its native entry preferences. This was a big step in unlocking the potential of developing this virus into a platform for both targeted drug delivery, where it would sneak drugs inside cancer cells, and oncolytic virotherapy, where the virus itself destroys cancer cells."
- Elizabeth K. Gardner, Writer
December 18, 2014
Three Purdue University professors have been named fellows of the National Academy of Inventors.Read Full Story
December 5, 2014
Postdoctoral researchers at Purdue University will have a chance to gain valuable proposal writing and reviewing experience in translational research, as well as the chance to win $5,000 for their own research, through the Purdue Postdoc Challenge.Read Full Story
November 14, 2014
The Purdue administration of the Indiana Clinical and Translational Sciences Institute (Indiana CTSI) is offering post-doctoral investigators two $5000 grants for the use of specific Purdue core facilities.Read Full Story