Bindley Bioscience Center

Academic Researchers

Bridging Chemistry Innovation and Invention at the BBC

Bringing together researchers and technologies from diverse disciplines is the primary goal at the Bindley Bioscience Center. This provides an ideal environment for translational research. For Dr. Garth Simpson's research with Nonlinear Optics, the Bindley provides both the environment for technology development and the opportunity for coalesce teams of researchers with specific problems that can be addressed by these technologies. Dr. Simpson and his colleagues have developed a new approach to protein crystal screening employing the nonlinear optical effect second harmonic generation (SHG). The system eliminates background noise in the crystal structure screening process and provides accurate analysis at the nanomolecular scale while reducing the amount of sample required, and eliminating some reagents from the process entirely. These and other approaches in optical engineering are facilitated by the research infrastructure at Discovery Park, including the nanofabrication capabilities of the Birck Nanotechnology Center, adjacent to the Bindley.

Garth was recently co-principal investigator on a NIH center grant proposal to apply this crystal screening technology to structural analyses of membrane proteins. The Bindley became the instrument to bring structural biologists together with the technology development efforts in Garth's lab. This technology is also applicable to other research problems, such as analyses of the purity of pharmaceutical preparations. This application is also being explored with collaborators at the Bindley.

"ANALYTICAL CHEMISTRY AND ITS INSTRUMENTS PROVIDE THE MEASUREMENTS AND QUANTITATIVE INFORMATION UNDERLYING MUCH OF THE RESEARCH AND COMMERCIAL ACTIVITY IN CHEMISTRY, BIOLOGY, AND MEDICINE."
- (CENTER FOR ANALYTICAL INSTRUMENTATION DEVELOPMENT HOMEPAGE, 2008)

Dr. Simpson participates in the Bindley's Center for Analytical Instrumentation Development (CAID), established in July 2008. Integrating the efforts of multiple institutions across multiple disciplines, CAID provides expertise necessary for practical instrument solutions for diverse research approaches. Core technologies at the Bindley compliment the instrument development process, with corresponding analytical analytical and molecular analyses, for example. CAID provides researchers with the resources necessary to develop the devices that will enable next advances in life-science.

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Interdisciplinary life sciences and engineering researchers collaborate to explore new technologies and scientific knowledge that impact the broad boundaries of plant, animal, and human diseases.


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Bindley Bioscience Center
1203 W. State Street
Purdue University
West Lafayette, IN 47907-2057