Internal Steering Committee

Sherry Harbin

Professor of Biomedical Engineering
Professor of Basic Medical Sciences
Weldon School of Biomedical Engineering
B.S., Biochemistry (Honors), Indiana University, 1987 M.S., Electrical Engineering, Purdue University, 1989 Ph.D., Veterinary Physiology and Pharmacology, Purdue University
Tissue Engineering/Biomaterials Extracellular Matrix Cell-Extracellular Matrix Biomechanics Mechanotransduction 3D Culture Systems Bioimaging and Image Analysis
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Marietta Harrison

Special Adviser for Strategic Initiatives
Director, Oncological Sciences Center - Discovery Park
Associate Director, Center for Cancer Research
Professor of Medicinal Chemistry and Molecular Pharmacology in the College of Pharmacy
B.A., University of new Hampshire Ph.D., University of Wyoming Postdoc, Fred Hutchinson Cancer Research Center, Seattle
Biochemistry and Molecular Biology Our group studies the signaling molecule Lck, a member of the Src-family of protein tyrosine kinases. Lck is required for the activation of T-lymphocytes (T-cells) and individuals lacking functional T-cells fail to develop immune responses. In addition to protecting the body from the invasion of foreign pathogens, the immune system is thought to impact the development of cancer. In the case of cancer vaccine development, the immune system actually impedes the therapy of cancer and harnessing the immune system to aid in the prevention and treatment of tumors has been an ongoing strategy in the war against cancer. In addition to its requisite role in T cell development and activation, Lck is itself an oncogene and the forced expression of a constitutively active form in mice leads to the development of thymic tumors. Lck is thus an important player in the field of cancer immunology and a critical player in the overall immune response. We study all aspects of the regulation and function of Lck and the signaling pathways its activation initiates. Recently, we have concentrated on its cellular localization and its modification by serine phosphorylation, which occurs following the binding of antigen to the T-lymphocyte receptor (TCR) as well as during mitosis. Our group additionally is involved in collaborative projects with both the Gibbs and Post laboratories. With the Gibbs lab, we focus on designing and synthesizing chemical analogs of palmitic acid that will prevent Lck from entering lipid rafts. With the Post lab, we focus on determining the three dimensional structure of serine phosphorylated Lck.
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Jessica Huber, Ph.D.

Professor of Speech, Language, and Hearing Sciences
Ph.D.
B.A., English, Saint John Fisher College, Rochester, NY M.A., Speech/Lang Path, University at Buffalo Ph.D., Speech Science, University at Buffalo
Professor Huber developed a new treatment for individuals with Parkinson's disease which will allow treatment to take place in everyday communication environments, rather than in the clinic, increasing the generalization of improved communication to patient's daily life even for those with moderate to severe impairments. This treatment involves the use of a small wearable device called the SpeechVive which cues patients to talk louder and clearer through the use of the Lombard Effect. She demonstrated its effectiveness in a two-site clinical efficacy study and patented the technology. Due her efforts in commercialization with assistance from partners at Purdue University, the SpeechVive will be on the market in 2013. Professor Huber is also examining how communication and treatment gains are affected by other common tasks (for example, how speech and language production change when a person is walking and talking, rather than just sitting and talking). To achieve this research goal, Dr. Huber collaborates with other researchers in the areas of linguistics, balance, gait, and psychosocial factors along with neurologists, speech therapists, and physical therapists. Professor Huber was recently named as the Burton D. Morgan Entrepreneur in Residence at Discovery Park. As the Entrepreneur in Residence, she assists other faculty and students who are working to translate or commercialize their ideas. She works with the leaders and staff from Discovery Park to improve the pipeline for research to impact the Indiana and U.S. economy.
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Laurie Jaeger

Professor and Department Head of Basic Medical Sciences
B.S., Animal Science, The Pennsylvania State University D.V. M., Veterinary Medicine, Purdue University Ph.D., Veterinary Anatomy, Purdue University
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Yoon Yeo

Associate Professor of Industrial and Physical Pharmacy
Associate Professor (by courtesy) of Biomedical Engineering
Controlled Drug Delivery, Bio-nanotechnology, Tissue Engineering
Professor Yeo's research focuses on developing new drug delivery systems and biomaterials enabling safe, efficient, and clinically viable delivery of drugs, genes and/or cells in a target-specific manner. In particular, Professor yeo is interested in developing drug formulations that will enhance site-specific drug distribution for therapy of tumors or chronic pulmonary diseases.
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