Internal Steering Committee
Sherry L. Harbin, Ph.D.
Professor of Biomedical Engineering
Professor of Basic Medical Sciences
Weldon School of Biomedical Engineering
B.S., Biochemistry (Honors), Indiana University, 1987
M.S., Electrical Engineering, Purdue University, 1989
Ph.D., Veterinary Physiology and Pharmacology, Purdue University
- Tissue Engineering/Biomaterials
- Extracellular Matrix
- Cell-Extracellular Matrix Biomechanics
- 3D Culture Systems
- Bioimaging and Image Analysis
Marietta L. Harrison, Ph.D.
Associate Vice-President for Research
Director, Oncological Sciences Center
Associate Director, Purdue University Center for Cancer Research
Professor of Medicinal Chemistry and Molecular Pharmacology
B.A., University of new Hampshire
Ph.D., University of Wyoming
Postdoc, Fred Hutchinson Cancer Research Center, Seattle
Research: Biochemistry and Molecular Biology
Our group studies the signaling molecule Lck, a member of the Src-family of protein tyrosine kinases. Lck is required for the activation of T-lymphocytes (T-cells) and individuals lacking functional T-cells fail to develop immune responses. In addition to protecting the body from the invasion of foreign pathogens, the immune system is thought to impact the development of cancer. In the case of cancer vaccine development, the immune system actually impedes the therapy of cancer and harnessing the immune system to aid in the prevention and treatment of tumors has been an ongoing strategy in the war against cancer. In addition to its requisite role in T cell development and activation, Lck is itself an oncogene and the forced expression of a constitutively active form in mice leads to the development of thymic tumors. Lck is thus an important player in the field of cancer immunology and a critical player in the overall immune response.
We study all aspects of the regulation and function of Lck and the signaling pathways its activation initiates. Recently, we have concentrated on its cellular localization and its modification by serine phosphorylation, which occurs following the binding of antigen to the T-lymphocyte receptor (TCR) as well as during mitosis. Our group additionally is involved in collaborative projects with both the Gibbs and Post laboratories. With the Gibbs lab, we focus on designing and synthesizing chemical analogs of palmitic acid that will prevent Lck from entering lipid rafts. With the Post lab, we focus on determining the three dimensional structure of serine phosphorylated Lck.
Honors and Credentials
- Walther Cancer Institute “Collaborator of the Year Award” 2006
- Purdue Cancer Research Award, 1988
- National Institutes of Health, National Research Service Award, 1981-1983
- Cancer Research Institute Postdoctoral Fellowship, 1980-1981
Jessica Huber, Ph.D.
Associate Professor of Speech, Language, and Hearing Sciences
B.A., English, Saint John Fisher College, Rochester, NY
M.A., Speech/Lang Path, University at Buffalo
Ph.D., Speech Science, University at Buffalo
Research: Speech Science
Professor Huber developed a new treatment for individuals with Parkinson's disease which will allow treatment to take place in everyday communication environments, rather than in the clinic, increasing the generalization of improved communication to patient's daily life even for those with moderate to severe impairments. This treatment involves the use of a small wearable device called the SpeechVive which cues patients to talk louder and clearer through the use of the Lombard Effect. She demonstrated its effectiveness in a two-site clinical efficacy study and patented the technology. Due her efforts in commercialization with assistance from partners at Purdue University, the SpeechVive will be on the market in 2013.
Professor Huber is also examining how communication and treatment gains are affected by other common tasks (for example, how speech and language production change when a person is walking and talking, rather than just sitting and talking). To achieve this research goal, Dr. Huber collaborates with other researchers in the areas of linguistics, balance, gait, and psychosocial factors along with neurologists, speech therapists, and physical therapists.
Professor Huber was recently named as the Burton D. Morgan Entrepreneur in Residence at Discovery Park. As the Entrepreneur in Residence, she assists other faculty and students who are working to translate or commercialize their ideas. She works with the leaders and staff from Discovery Park to improve the pipeline for research to impact the Indiana and U.S. economy.
Honors and Credentials
- Outstanding Graduate Faculty Instructor in the Department of Speech, Language, and Hearing Sciences 2011
- Outstanding Undergraduate Faculty Instructor in Department of Speech, Language, and Hearing Sciences 2006
- Outstanding Faculty Instructor in Department of Speech, Language, and Hearing Sciences 2005
- Honors for Outstanding Leadership and Achievement, National Student Speech Language Hearing Association 2000
Laurie Jaeger, DVM, Ph.D.
Professor and Department Head of Basic Medical Sciences
B.S., Animal Science, The Pennsylvania State University
D.V. M., Veterinary Medicine, Purdue University
Ph.D., Veterinary Anatomy, Purdue University
Honors and Credentials
- 2006 Piper Professor, Minnie Stevens Piper Foundation, San Antonio, Texas
- 2005 Presidential Professor for Teaching Excellence, Texas A&M University
- 2005 Texas Veterinary medical Association Faculty Achievement Award for Outstanding Accomplishment in Teaching
- 2004-2005 Center for Teaching Excellence Faculty Associate
- 2001 Texas A&M Association of Former Students Faculty Distinguished Achievement Award in Teaching
- 1999 Wiley Distinguished Teaching professorship in Veterinary Medicine
- 1997 Texas A&M Association of Former Students College-Level Distinguished Teaching Award
- 1996-1997 Center for Teaching Excellence Scholar for the College of Veterinary Medicine, Texas A&M University, College Station, Texas
Yoon Yeo, Ph.D.
Associate Professor of Industrial and Physical Pharmacy
Associate Professor (by courtesy) of Biomedical Engineering
B.S., Pharmacy, Seoul National University, Seoul, Korea
M.S., Microbial Chemistry, Seoul National University, Seoul, Korea
Ph.D., Pharmaceutics, Purdue University
Post-doctoral Associate, Chemical Engineering, Massachusetts Institute of Technology, MA
Research: Controlled Drug Delivery, Bio-nanotechnology, Tissue Engineering
Professor Yeo's research focuses on developing new drug delivery systems and biomaterials enabling safe, efficient, and clinically viable delivery of drugs, genes and/or cells in a target-specific manner. In particular, Professor yeo is interested in developing drug formulations that will enhance site-specific drug distribution for therapy of tumors or chronic pulmonary diseases.
Honors and Credentials
- 2014 Showalter Faculty Scholar
- 2011 NSF Career Award
- 2009 AAPS New Investigator Grant Award in Pharmaceutics and Pharmaceutical Technologies
- 2008 AACP New Investigators program for Pharmacy Faculty
Women’s Global Health Institute
Discovery Park and College of Health and Human Sciences
Hall for Discovery and Learning Research, Room 395
207 South Martin Jischke Drive
West Lafayette, IN 47907-1971