Center for Global Research and Intervention in Infectious Diseases

C-GRIID Scientists Reveal the Crystal Structure of Human Enterovirus 71

March 27, 2012

C-GRIID affiliated researchers have determined the 3.8-angstrom resolution crystal structure of the human enterovirus 71 - an RNA virus member of the picornavirus family that may lead to paralysis and encephalitis in infants and young children. The structure of the virus revealed a small hydrophobic pocket molecule that likely becomes exposed prior to the release of genetic material during the infection process. Drugs that target this exposed molecule, the authors suggest, could potentially be effective in neutralizing the virus. The research is published in Science Magazine: P Plevka, et. al., Crystal structure of human enterovirus 71, Science, DOI:10.1126/science.1218713, 2012.
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