Center for Global Research and Intervention in Infectious Diseases

Seminar on real-time in vivo imaging of host neutrophils in Bacillus anthracis infection

September 2 @ 3:30 PM - 5:00 PM - Veterinary Pathology Building (VPTH), Room 112

Title: “Real-time analysis of host-pathogen interactions in anthrax”

Speaker: Ian Glomski, PhD - Assistant Professor, School of Medicine, University of Virginia, Charlottesville, Virginia

Venue: Veterinary Pathology Building (VPTH), Room 112

Date: September 2, 2010 Time: 3:30PM

Abstract: B. anthracis is a spore forming Gram positive bacterial pathogen that is the etiological agent of the disease anthrax. Infection can occur via three different routes, gastro-intestinal, cutaneous, or pulmonary. Systemic disease is associated with both toxemia and septicemia; where two secreted toxins, lethal toxin and edema toxin, are responsible for toxemia. It remains unclear precisely how B. anthracis exotoxins promote bacterial growth and dissemination. Using luminescence-based real time analysis of bacteria and mouse neutrophils we explored the affects of toxin production on both the dissemination of bacteria and the accumulation of neutrophils in the site of infection. We found that bacterial toxin production altered the rates and patterns of bacterial dissemination and reduced the number of neutrophils within the site of infection. These data suggest that B. anthracis exotoxins act in vivo to cripple the inflammatory response, which intern promotes bacterial growth within the murine host and helps explain the high mortality associated with anthrax.

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