M.S. Zhejiang University College of Pharmacy, Hangzhou, Pharmacology
Ph.D. University of Arizona, Tucson, AZ Pharmacology & Toxicology
Toxicology of blood-brain barrier and blood-CSF barrier.
Neurotoxicology of heavy metals (lead, manganese, iron, aluminum, and mercury): transport, homeostasis in the CNS, and molecular mechanisms.
Roles of brain barriers in etiology of neurodegenerative diseases such as Parkinson′s syndrome and Alzheimer′s disease.
Chelation therapy of metal toxicities.
Transport of substances by the blood-CSF barrier in the choroid plexus.
In vitro model of blood-brain/CSF barrier.
HSCI 101 Introduction to the Health Sciences Professions
National Institutes of Health-National Institute of Environmental Health Sciences
National Institutes of Health-National Institute of Neurological Disorders and Stroke
U.S. Department of Defense
Behl M, Zhang YZ, Shi YZ, and Zheng W (2010). Lead-induced increase in β-amyloid accumulation in the choroid plexus: Role of low density lipoprotein receptor protein-1 and protein kinase C activity. NeuroToxicology 31:524-532.
Louis ED and Zheng W (2010). Beta-carboline alkaloids and essential Tremor: Exploring the environmental determinants of one of the most prevalent neurological diseases. TSW The Scientific World Journal 10:1783-1794
Zheng W, Fu SX, Dydak U, and Cowan DM (2010). Biomarkers of manganese intoxication. NeuroToxicology (in press)
Kanoski SE, Zhang Y, Zheng W, Davidson TL (2010). Effects of a high-energy diet on hippocampal-dependent Pavlovian discrimination learning and blood-brain barrier integrity. Hippocampus (in press)
Dydak U, Jiang YM, Long LL, Zhu H, Chen J, Li WM, Edden RAE, Hu SG, Fu X, Long ZY, Mo XA, Meier D, Harezlak J, Aschner M, Murdoch J, and Zheng W (2010). In vivo measurement of brain GABA concentrations by magnetic resonance spectroscopy in smelters occupationally exposed to manganese. Env Health Persp (in press) 119:000–000 doi:10.1289/ehp.1002192.
Hong L, Jiang W, Zeng S, and Zheng W (2010). HPLC analysis of para-aminosalicylic acid and its metabolite in plasma, cerebrospinal fluid and brain tissues. J Pharmaceut Biomed Analysis (in press) doi:10.1016/j.jpba.2010.11.031.
Monnot AD, and Zheng W (2010). Culture of choroidal plexus epithelial cells and in vitro model of blood-CSF barrier. Methods Mol Biol (in press)
Chen RL, Preston JE, and Zheng W (2010). Thyroid hormone transport across blood-brain barriers. In: Thyroid Hormones: Functions, Related Diseases and Uses. Ed. Columbus F. Nova Science Publishers, Hauppauge NY. (in press)
Gu H, Wei X, Monnot AD, Fontanilla CV, Behl M, Zheng W, and Du YS (2010). Lead exposure increases levels of beta-amyloid in the CSF and brain tissues and inhibits LRP1 expression in APP transgenic mice. Neurosci Letters (in press)
Davidson, T. L., Monnot, A. D., Neal, A. U., Martin, A. A., Horton, J. J., & Zheng, W. (2012). The effects of a high-energy diet on hippocampal-dependent discrimination performance and blood-brain barrier integrity differ for diet-induced obese and diet-resistant rats. Physioloogy & Behavior, 107, 26-33.
Gu, H. Y., Robison, G., Barrea, P., Hong, L., Barrea, R., Wei, X., Farlow, M. R., Pushkar, Y. N., Du, Y. S., & Zheng, W. (2012). Increased ?-amyloid deposition in Tg-SWDI transgenic mouse brain following in vivo lead exposure. Toxicology Letters, 213, 211-219.
Li, H., Zhou, D. L., Zhang, Q., Feng, C. Y., Zheng, W., He, K. P., & Lan, Y. J. (2013). Vanadium exposure-induced neurobehavioral alterations among Chinese workers. Neurotoxicology, 36, 49-54.
Louis, E. D., Benito-León, J., Moreno-García, S., Vega, S., Romero, J. P., Bermejo-Pareja, F., Gerbin, M., Viner, A.S., Factor-Litvak, P., Jiang, W., & Zheng, W. (2013). Blood harmane (1-methyl-9h-pyrido[3,4-B]indole) concentration in essential tremor cases in Spain. Neurotoxicology, 34, 264-268.
Louis, E. D., Jiang, W., Gerbin, M., Viner, A. S., Factor-Litvak, P., & Zheng, W. (2012). Blood harmane (1-methyl-9h-pyrido[3,4-b]indole) concentrations in essential tremor: Repeat observation in cases and controls in New York. Journal of Toxicology and Environmental Health. Part A, 5, 673-683.
Monnot, A. D., & Zheng, W. (2012). Culture of choroidal plexus epithelial cells and in vitro model of blood-CSF barrier. Methods in Molecular Biology (Epithelial Cell Culture Protocols) 945, 13-29.
Monnot, A. D., Zheng, G., & Zheng, W. (2012). Mechanism of copper transport at the blood-cerebrospinal fluid barrier: Influence of iron deficiency. Experimental Biology and Medicine, 237, 327-333.
Park, J. D., & Zheng, W. (2012). Human exposure and health effects of inorganic and elemental mercury (Review). Journal of Preventive Medicine and Public Health, 45, 344-352.
Racette, B. A,, Aschner, M., Guilarte, T. R., Dydak, U., Criswell, S. R., & Zheng, W. (2012). Pathophysiology of manganese-associated neurotoxicity. Neurotoxicology ,33, 881-886.
Robison, G., Zakharova, T., Fu, X., Jiang, W., Fulper, R., Barrea, R., Marcus, M. A., Zheng, W., & Pushkar, Y. (2012). X-ray fluorescence imaging: A new tool for studying manganese neurotoxicity. PLoS ONE, 7(11), e48899.
Rutchik, J. S., Zheng, W., Jiang, Y. M., & Mo, X. E. (2012). How does an occupational neurologist assess welders and steelworkers for a manganese-induced movement disorder? An international team's experiences in Guangxi, China, Part II. Journal of Occupational and Environmental Medicine, 54(12), 1562-1564.
Rutchik, J. S., Zheng, W., Jiang, Y. M., & Mo, X. E. (2012). How does an occupational neurologist assess welders and steelworkers for a manganese-induced movement fisorder? An international team's experiences in Guangxi, China, Part I. Journal of Occupational and Environmental Medicine, 54(11), 1432-1434.
Zheng, G., Chen, J., & Zheng, W. (2012). Relative contribution of CTR1 and DMT1 in copper transport by the blood-CSF barrier: Implication in manganese neurotoxicity. Toxicology and Applied Pharmacology, 260, 285-293.
Zheng, W., & Monnot, A. D. (2012). Regulation of brain iron and copper homeostasis by brain barrier systems: Implication in neurodegenerative diseases. Pharmacology & Therapeutiacs, 133, 177-188.
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