M.S. Zhejiang University College of Pharmacy, Hangzhou, Pharmacology
Ph.D. University of Arizona, Tucson, AZ Pharmacology & Toxicology
Toxicology of blood-brain barrier and blood-CSF barrier.
Neurotoxicology of heavy metals (lead, manganese, iron, aluminum, and mercury): transport, homeostasis in the CNS, and molecular mechanisms.
Roles of brain barriers in etiology of neurodegenerative diseases such as Parkinson′s syndrome and Alzheimer′s disease.
Chelation therapy of metal toxicities.
Transport of substances by the blood-CSF barrier in the choroid plexus.
In vitro model of blood-brain/CSF barrier.
HSCI 101 Introduction to the Health Sciences Professions
National Institutes of Health-National Institute of Environmental Health Sciences
National Institutes of Health-National Institute of Neurological Disorders and Stroke
U.S. Department of Defense
Behl M, Zhang YZ, Shi YZ, and Zheng W (2010). Lead-induced increase in β-amyloid accumulation in the choroid plexus: Role of low density lipoprotein receptor protein-1 and protein kinase C activity. NeuroToxicology 31:524-532.
Louis ED and Zheng W (2010). Beta-carboline alkaloids and essential Tremor: Exploring the environmental determinants of one of the most prevalent neurological diseases. TSW The Scientific World Journal 10:1783-1794
Zheng W, Fu SX, Dydak U, and Cowan DM (2010). Biomarkers of manganese intoxication. NeuroToxicology (in press)
Kanoski SE, Zhang Y, Zheng W, Davidson TL (2010). Effects of a high-energy diet on hippocampal-dependent Pavlovian discrimination learning and blood-brain barrier integrity. Hippocampus (in press)
Dydak U, Jiang YM, Long LL, Zhu H, Chen J, Li WM, Edden RAE, Hu SG, Fu X, Long ZY, Mo XA, Meier D, Harezlak J, Aschner M, Murdoch J, and Zheng W (2010). In vivo measurement of brain GABA concentrations by magnetic resonance spectroscopy in smelters occupationally exposed to manganese. Env Health Persp (in press) 119:000–000 doi:10.1289/ehp.1002192.
Hong L, Jiang W, Zeng S, and Zheng W (2010). HPLC analysis of para-aminosalicylic acid and its metabolite in plasma, cerebrospinal fluid and brain tissues. J Pharmaceut Biomed Analysis (in press) doi:10.1016/j.jpba.2010.11.031.
Monnot AD, and Zheng W (2010). Culture of choroidal plexus epithelial cells and in vitro model of blood-CSF barrier. Methods Mol Biol (in press)
Chen RL, Preston JE, and Zheng W (2010). Thyroid hormone transport across blood-brain barriers. In: Thyroid Hormones: Functions, Related Diseases and Uses. Ed. Columbus F. Nova Science Publishers, Hauppauge NY. (in press)
Gu H, Wei X, Monnot AD, Fontanilla CV, Behl M, Zheng W, and Du YS (2010). Lead exposure increases levels of beta-amyloid in the CSF and brain tissues and inhibits LRP1 expression in APP transgenic mice. Neurosci Letters (in press)
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